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Artículo
New insights into the genetic etiology of Alzheimer’s disease and related dementias
(Nature Publishing Group, 2022)
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a ...
Artículo
SEOM clinical guidelines for the treatment of Hodgkin’s lymphoma
(Springer, 2015)
Hodgkin lymphoma (HL) is an uncommon B cell lymphoid malignancy representing approximately 10–15 % of all lymphomas. HL is composed of two dis tinct disease entities; the more commonly diagnosed clas sical HL and the ...
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Association between reperfusion therapy and outcomes in patients with acute pulmonary embolism and right heart thrombi
(European Respiratory Society, 2020)
Right heart thrombi portend worse outcomes in pulmonary embolism (PE). In propensity-matched analyses of patients from a large registry, reperfusion therapy was not associated with significantly reduced odds of all-cause ...
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Current HHT genetic overview in Spain and its phenotypic correlation: data from RiHHTa registry
(Biomed central LTD, 2020)
Background: Hereditary hemorrhagic telangiectasia (HHT) is a rare vascular disease with autosomal dominant inheritance. Disease-causing variants in endoglin (ENG) and activin A receptor type II-like 1 (ACVRL1) genes are ...
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Artículo
BIChromET: A Chromogenic Culture Medium for Detection of Piperacillin/Tazobactam and Cefepime Resistance in Pseudomonas aeruginosa
(MDPI, 2023)
Objectives: The BIChromET selective medium for detecting piperacillin-tazobactam (TZP) and cefepime (FEP) resistant Pseudomonas aeruginosa was developed. Methods: The performance of this medium was first evaluated using a ...
Artículo
Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF‑mutated melanoma treated in the randomized coBRIM study
(Biomed Central LTD, 2017)
Background: Serous chorioretinopathy has been associated with MEK inhibitors, including cobimetinib. We describe the clinical features of serous retinopathy observed with cobimetinib in patients with BRAFV600-mutated ...
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The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology
(Elsevier, 2020)
Herein, we describe, for the first time, 3 different clinical courses of acute decompensation (AD) of cirrhosis after hospital admission. The first clinical course includes patients who develop acute-on-chronic liver failure ...
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Prevalence, Incidence, and Risk Factors for Intestinal Colonization Due to Fluoroquinolone-Resistant ST131 Escherichia coli: a Longitudinal Study in Highly Dependent, Long-Term Care Facility Residents
(American Society for Microbiology, 2022)
Escherichia coli ST131 clade C is an important driver for fluoroquinolone resistance (FQ-R). We conducted a prospective observational study in residents from two long-term care facilities (LTCFs) in Seville, Spain, in 2018. ...
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Long-Term Effectiveness and Safety of Biologic and Small Molecule Drugs for Moderate to Severe Atopic Dermatitis: A Systematic Review
(MDPI AG, 2022)
Introduction: Atopic dermatitis (AD) is a genetically based chronic inflammatory dermato sis associated with multiple triggers and complex pathophysiological mechanisms. Nowadays, an authentic therapeutic revolution is ...