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Mostrando ítems 21-30 de 44
Artículo
Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats
(2003)
We studied the mechanisms underlying long-term functional recovery of hemiparkinsonian rats grafted intrastriatally with carotid body (CB) cell aggregates. Amelioration of their motor syndrome is a result of the trophic ...
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Bases neurobiológicas de la drogadicción
(Viguera, 2002)
Introduction. Drugs of abuse cause addiction, characterized by compulsive and out of control drug use. Several neurochemical and molecular changes take place in the brain during the first phase of drug use which lead to ...
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Selective Glial Cell Line-Derived Neurotrophic Factor Production in Adult Dopaminergic Carotid Body Cells In Situ and after Intrastriatal Transplantation
(2005)
Glial cell line-derived neurotrophic factor (GDNF) exerts a notable protective effect on dopaminergic neurons in rodent and primate models of Parkinson’s disease (PD). The clinical applicability of this therapy is, however, ...
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Dopamine induces intracellular Ca2+ signals mediated by alpha(1B)-adrenoceptors in rat pineal cells
(ELSEVIER SCIENCE BV, 2001)
We have studied the functional interaction of dopamine with a -adrenoceptor subtypes by measuring intracellular Ca2q 1 levels in pineal cells, a cell type where adrenoceptors are well characterized. We show that dopamine ...
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Treatment with trkC agonist antibodies delays disease progression in neuromuscular degeneration (nmd) mice
(OXFORD UNIV PRESS, 2005)
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a fatal autosomal recessive disorder seen in infants. It is characterized by lower motor neuron degeneration, progressive muscle paralysis and respiratory ...
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Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice
(2008)
Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 in the regulation of neuronal apoptosis. To better understand this function in vivo, we have created PHD3_/_ ...
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Metabotropic Ca2+ channel-induced Ca2+ release and ATP-dependent facilitation of arterial myocyte contraction
(2006)
Voltage-gated Ca2_ channels in arterial myocytes can mediate Ca2_ release from the sarcoplasmic reticulum and, thus, induce contraction without the need of extracellular Ca2_ influx. This metabotropic action of Ca2_ channels ...
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The spatial pattern of exocytosis and post-exocytic mobility of synaptopHluorin in mouse motor nerve terminals
(Wiley, 2009-03)
We monitored the spatial distribution of exo- and endocytosis at 37◦C in mouse motor nerve terminals expressing synaptopHluorin (spH), confirming and extending earlier work at room temperature, which had revealed fluorescent ...