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Artículo
Store-operated calcium entry in breast cancer cells is insensitive to Orai1 and STIM1 N-linked glycosylation
(MDPI, 2022-12-29)
N-linked glycosylation is a post-translational modification that affects protein function, structure, and interaction with other proteins. The store-operated Ca2+ entry (SOCE) core proteins, Orai1 and STIM1, exhibit ...
Artículo
Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells
(Springer, 2022)
The identification of two variants of the canonical pore-forming subunit of the Ca2+ release-activated Ca2+ (CRAC) channel Orai1, Orai1α and Orai1β, in mammalian cells arises the question whether they exhibit different ...
Artículo
TRPC Channels in the SOCE Scenario
(MDPI, 2020)
Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP ...
Artículo
Editorial: Molecular Components of Store-Operated Calcium Entry in Health and Disease
(Frontiers Media, 2021-10-05)
Store-Operated Calcium Entry (SOCE) is a ubiquitous Ca2+ influx mechanism first described in 1986 (Putney, 1986). This conserved mechanism results from the interaction between the tetraspanning ORAI1 channel located in ...
Artículo
EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction
(S. Karger AG, 2018-11-28)
Background/aims: STIM1 and Orai1 are the key components of store-operated Ca2+ entry (SOCE). Among the proteins involved in the regulation of SOCE, SARAF prevents spontaneous activation of SOCE and modulates STIM1 ...