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Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors
(American journal of clinical pathology, 2019)
Objectives: Study of aquaporin 1 (AQP1) and aquaporin 3 (AQP3) expression to understand its potential role in the pathophysiology of skin cancer. Methods: Analysis of AQP1 and AQP3 expression by immunohistochemistry ...
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A New Role for Myosin II in Vesicle Fission
(Public Library of Science, 2014-06-24)
An endocytic vesicle is formed from a flat plasma membrane patch by a sequential process of invagination, bud formation and fission. The scission step requires the formation of a tubular membrane neck (the fission pore) ...
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Combined effects of aquaporin-4 and hypoxia produce age-related hydrocephalus
(Elsevier, 2018)
Aquaporin-4, present in ependymal cells, in glia limiting and abundantly in pericapillary astrocyte foot pro cesses, and aquaporin-1, expressed in choroid plexus epithelial cells, play an important role in cerebrospinal fluid ...
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Selective expression of the neurexin substrate for presenilin in the adult forebrain causes deficits in associative memory and presynaptic plasticity
(Elsevier, 2021-10-15)
Presenilins (PS) form the active subunit of the gamma-secretase complex, which mediates the proteolytic clearance of a broad variety of type-I plasma membrane proteins. Loss-of-function mutations in PSEN1/2 genes are the ...
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Generation of human organs in pigs via interspecies blastocyst complementation
(Wiley-Blackwell Verlag GmbH, 2016-10-19)
More than eighteen years have passed since the first derivation of human embryonic stem cells (ESCs), but their clinical use is still met with several challenges, such as ethical concerns regarding the need of human embryos, ...
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Multiple Functions of the Vesicular Proton Pump in Nerve Terminals
(Cell Press, 2010-12-22)
Synaptic vesicles are acidified by a proton pump (vATPase), which allows vesicular uptake of neurotransmitters. After vesicle exocytosis, continued operation of the vATPase would seem to serve no useful function. In this ...
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Atypical measures of diffusion at the gray-white matter boundary in autism spectrum disorder in adulthood
(Wiley Open Access, 2020-10-23)
Autism spectrum disorder (ASD) is a highly complex neurodevelopmental condition that is accompanied by neuroanatomical differences on the macroscopic and microscopic level. Findings from histological, genetic, and more ...
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Lesion covariance networks reveal proposed origins and pathways of diffuse gliomas
(Oxford University Press, 2021-12-04)
Diffuse gliomas have been hypothesized to originate from neural stem cells in the subventricular zone and develop along previously healthy brain networks. Here, we evaluated these hypotheses by mapping independent sources ...
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The human-specific duplicated α7 gene inhibits the ancestral α7, negatively regulating nicotinic acetylcholine receptor-mediated transmitter release
(Amer Soc Biochemistry Molecular Biology Inc, 2021)
Gene duplication generates new functions and traits, enabling evolution. Human-specific duplicated genes in particular are primary sources of innovation during our evolution although they have very few known functions. ...
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Neodymium doped lanthanide fluoride nanoparticles as contrast agents for luminescent bioimaging and X-ray computed tomography
(Soc Española de Cerámica y Vidrio, 2022)
The synthesis of uniform neodymium-doped lanthanum trifluoride nanoparticles with lenticular shape and a mean diameter around 45 nm by using a homogeneous precipita- tion method is reported. The luminescent properties ...