Artículo
Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors
Autor/es | Osorio, Giovana
Zulueta-Dorado, Teresa González Rodríguez, Patricia Bernabéu-Wittel, José Conejo-Mir Sánchez, Julián Ramírez Lorca, Reposo Echevarría Irusta, Miriam |
Departamento | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2019 |
Fecha de depósito | 2024-02-16 |
Publicado en |
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Resumen | Objectives: Study of aquaporin 1 (AQP1) and
aquaporin 3 (AQP3) expression to understand its
potential role in the pathophysiology of skin cancer.
Methods: Analysis of AQP1 and AQP3 expression by
immunohistochemistry ... Objectives: Study of aquaporin 1 (AQP1) and aquaporin 3 (AQP3) expression to understand its potential role in the pathophysiology of skin cancer. Methods: Analysis of AQP1 and AQP3 expression by immunohistochemistry of 72 skin biopsy specimens from melanocytic skin tumors, nonmelanocytic tumors, or healthy samples. Results: AQP1 showed strong labeling in 100% of benign common melanocytic nevi. Small blood vessels, stroma, and melanophages surrounding different types of melanomas tumors also were positive. Tumoral melanocytes in atypical nevi and melanomas were negative for AQP1. AQP3 showed strong labeling in 100% of melanocytic nevi, 100% of atypical melanocytic nevi, and 100% of melanomas. In all basal cell carcinomas and squamous cell carcinomas, staining for AQP3 was positive. Conclusions: To our knowledge, this work represents the first demonstration of AQP1/AQP3 expression in human melanocytic skin tumors. More studies are needed to understand the underlying molecular mechanisms of expression of both AQPs in melanocytic tumors and their potential as molecular therapeutic targets. |
Cita | Osorio, G., Zulueta-Dorado, T., González Rodríguez, P., Bernabéu-Wittel, J., Conejo-Mir Sánchez, J., Ramírez Lorca, R. y Echevarría Irusta, M. (2019). Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors. American journal of clinical pathology, 152 (4), 446-457. https://doi.org/10.1093/ajcp/aqz066. |
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