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Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis
(Nature Publishing Group, 2021-06-12)
SOS1 ablation causes specific defective phenotypes in MEFs including increased levels of intracellular ROS. We showed that the mitochondria-targeted antioxidant MitoTEMPO restores normal endogenous ROS levels, suggesting ...
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R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy
(Elsevier, 2020-02-21)
Neurotransmission defects and motoneuron degeneration are hallmarks of spinal muscular atrophy, a monogenetic disease caused by the deficiency of the SMN protein. In the present study, we show that systemic application ...
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Editorial: Involvements of TRP channels, oxidative stress and apoptosis in neurodegenerative diseases
(Fontiers Media SA, 2021)
The oxygen free radicals generated during metabolism can cause cumulative oxidative damage to nucleic acids, lipids, and protein, resulting in structural degeneration, apoptosis, functional decline, and age-related ...
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Preferred Sites of Exocytosis and Endocytosis Colocalize during High- But Not Lower-Frequency Stimulation in Mouse Motor Nerve Terminals
(SOC NEUROSCIENCE, 2009)
The spatial relationship of exocytosis and endocytosis in motor nerve terminals has been explored, with varied results, mostly in fixed preparations and without direct information on the utilization of each exocytic site. ...
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Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells
(Wiley-Blackwell Publishing Ltd., 2003)
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from inhibition of O2 -regulated K+ channels. However, the mechanisms involved in the detection of changes ...
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Compulsivity is linked to reduced adolescentdevelopment of goal-directed control andfrontostriatal functional connectivity
(National Academy of Sciences, 2020)
A characteristic of adaptive behavior is its goal-directed nature. Anability to act in a goal-directed manner is progressively refinedduring development, but this refinement can be impacted by theemergence of psychiatric ...
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The carotid body, a neurogenic niche in the adult peripheral nervous system
(Univ pisa, 2010)
We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the peripheral nervous system. These progenitor cells support neurogenesis in vivo in response to ...
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Elixir of life thwarting aging with regenerative reprogramming
(Lippincott williams & wilkins, 2018-01)
All living beings undergo systemic physiological decline after ontogeny, characterized as aging. Modern medicine has increased the life expectancy, yet this has created an aged society that has more predisposition to ...
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Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
(Nature Portfolio, 2020)
Neurodevelopmental disorders have a heritable component and are associated with region specific alterations in brain anatomy. However, it is unclear how genetic risks for neurodevelopmental disorders are translated into ...