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Mostrando ítems 321-330 de 332
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Carotid body chemosensory responses in mice deficient of TASK channels
(2010)
Background K+ channels of the TASK family are believed to participate in sensory transduction by chemoreceptor (glomus) cells of the carotid body (CB). However, studies on the systemic CB-mediated ventilatory response to ...
Artículo
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An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence
(Wiley, 2024)
Abstract: There is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer recurrence and metastases. Recent studies have shown that presence of senescent cells in tissues ...
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Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion
(Frontiers Research Foundation, 2018-07-03)
Aims: Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R) injuries. However, little is known about its role in the regulation of intracellular Ca2+ concentration ([Ca2+]i) under I/R. Here, ...
Artículo
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Proteoglycans involved in bidirectional communication between mast cells and hippocampal neurons
(BMC, 2019-05-20)
Background: Mast cells (MCs) in the brain can respond to environmental cues and relay signals to neurons that may directly influence neuronal electrical activity, calcium signaling, and neurotransmission. MCs also ...
Artículo
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Circulating miR-320a as a Predictive Biomarker for Left Ventricular Remodelling in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention
(2020)
Restoration of epicardial coronary blood flow, achieved by early reperfusion with primary percutaneous coronary intervention (PPCI), is the guideline recommended to treat patients with ST-segment-elevation myocardial ...
Artículo
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TRPC and TRPV Channels’ Role in Vascular Remodeling and Disease
(doi:10.3390/ijms21176125, 2020-08-25)
Transient receptor potentials (TRPs) are non-selective cation channels that are widely expressed in vascular beds. They contribute to the Ca2+ influx evoked by a wide spectrum of chemical and physical stimuli, both in ...
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Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment
(MDPI, 2022)
bstract: Boron Neutron Capture Therapy (BNCT) is a promising binary disease-targeted therapy, as neutrons preferentially kill cells labeled with boron (10B), which makes it a precision medicine treatment modality that ...
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Transcriptomic analysis reveals an association of FCGBP with Parkinson’s disease
(Nature Research, 2022-11-12)
Transcriptomics in Parkinson’s disease (PD) offers new insights into the molecular mechanism of PD pathogenesis. Several pathways, such as inflammation and protein degradation, have been identified by differential gene ...
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IGF-1 regulates astrocytic phagocytosis and inflammation through the p110α isoform of PI3K in a sex-specific manner
(Willey, 2022)
Insulin-like growth factor-I (IGF-I) signaling plays a key role in neuroinflammation. Here we show that IGF-1 also regulates phagocytosis of reactive astrocytes through p110α isoform of phosphatidylinositol 3-kinase ...
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NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction
(Impact Journals LLC, 2017-09-08)
The NLRP3-inflammasome complex has emerged as an important component of inflammatory processes in metabolic dysfunction induced by high-caloric diets. In this study, we investigate the molecular mechanisms by which NLRP3 ...