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Mast Cell Changes the Phenotype of Microglia via Histamine and ATP
(KARGER, 2021)
Background/Aims: Microglia are the dynamic motile phagocytes of the brain considered the first line of defense against threats or disturbances to the Central Nervous System (CNS). Microglia help orchestrate the immunological ...
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Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity
(Wiley Open Access, 2020)
Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse disease ...
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Podoplanin Gene Disruption in Mice Promotes in vivo Neural Progenitor Cells Proliferation, Selectively Impairs Dentate Gyrus Synaptic Depression and Induces Anxiety-Like Behaviors.
(2020-01-15)
Podoplanin (Pdpn), a brain-tumor-related glycoprotein identified in humans and animals, is endogenously expressed in several organs critical for life support such as kidney, lung, heart and brain. In the brain, Pdpn has ...
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Eficacia antiparkinsoniana de trasplantes de paraganglio carotídeo y aórtico abdominal
(Organització catalana de trasplantaments. Servei català de la salut societat catalana de trasplantament, 2000)
Artículo
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Novel SCAMPs Lacking NPF Repeats: Ubiquitous and Synaptic Vesicle-Specific Forms Implicate SCAMPs in Multiple Membrane- Trafficking Functions
(2000)
In vertebrates, secretory carrier membrane proteins (SCAMPs) 1–3 constitute a family of putative membrane-trafficking proteins composed of cytoplasmic N-terminal sequences with NPF repeats, four central transmembrane regions ...
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The HERC1 ubiquitin ligase regulates presynaptic membrane dynamics of central synapses
(Nature Research, 2020-07-21)
HERC1 is a ubiquitin ligase protein, which, when mutated, induces several malformations and intellectual disability in humans. The animal model of HERC1 mutation is the mouse tambaleante characterized by: (1) overproduction ...
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La plasticidad sináptica mediada por endocannabinoides y «trastornos por consumo de drogas»
(Elsevier, 2019)
Las drogas impactan en los circuitos de recompensa cerebrales y originan depen dencia y adicción, lo que se define actualmente como trastornos por consumo de drogas. Los mecanismos de plasticidad sináptica en dichos ...
Artículo
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Sushi domain-containing protein 4 controls synaptic plasticity and motor learning
(2021)
Fine control of protein stoichiometry at synapses underlies brain function and plasticity. How proteostasis is controlled independently for each type of synaptic protein in a synapse-specific and activity-dependent manner ...
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HIF-2a is essential for carotid body development and function
(eLife Sciences Publications, 2018-04-19)
Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations facilitated by the sympathetic nervous system and carotid body (CB). Interactions between differing ...
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Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2
(2003)
We tested the long-standing hypothesis that synaptotagmin 1 is the Ca2 +_ sensor for fast neurosecretion by analyzing the intracellular Ca 2+ dependence of large dense-core vesicle exocytosis in a mouse strain carrying a ...