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MECHANISMS OF DISEASE Acute Oxygen-Sensing Mechanisms
(Massachusetts Medical Society, 2005)
JOSEPH PRIESTLEY, ONE OF THE THREE SCIENTISTS CREDITED WITH THE discovery of oxygen, described the death of mice that were deprived of oxygen. However, he was also well aware of the toxicity of too much oxygen, stating, ...
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Furin prodomain ppfurin enhances ca2+ entry through orai and trpc6 channels’ activation in breast cancer cells
(MDPI, 2021-04-01)
Furin, a proprotein convertase that belongs to a family of Ca2+-dependent serine peptidases, is involved in the maturation of a variety of proproteins, including growth factors, receptors and differentiation factors, ...
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Deletion of CASK in mice is lethal and impairs synaptic function
(2007)
CASK is an evolutionarily conserved multidomain protein composed of an N-terminal Ca2_/calmodulin-kinase domain, central PDZ and SH3 domains, and a C-terminal guanylate kinase domain. Many potential activities for CASK ...
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Editorial: Molecular Components of Store-Operated Calcium Entry in Health and Disease
(Frontiers Media, 2021-10-05)
Store-Operated Calcium Entry (SOCE) is a ubiquitous Ca2+ influx mechanism first described in 1986 (Putney, 1986). This conserved mechanism results from the interaction between the tetraspanning ORAI1 channel located in ...
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First aid kit for hypoxic survival: sensors and strategies
(University of Chicago Press, 2010)
Survival success under conditions of acute oxygen deprivation depends on efficiency of the central and peripheral chemoreception, optimization of oxygen extraction from the hypoxic environment and its delivery to the ...
Capítulo de Libro
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Neurofisiología de la acción psicotécnica del cannabis y endocannabinoides
(Sociedad Española de Investigación en Cannabinoides (SEIC), 2008)
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Aquaporin-4 expression switches from white to gray matter regions during postnatal development of the central nervous system
(MDPI, 2023-02-03)
Aquaporin-4 (AQP4) is the most abundant water channel in the central nervous system and plays a fundamental role in maintaining water homeostasis there. In adult mice, AQP4 is located mainly in ependymal cells, in the ...
Artículo
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Glucose sensing by carotid body glomus cells: potential implications in disease
(Frontiers Media, 2014-10-15)
The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. CB glomus cells have also been found to detect hypoglycemia in both non-primate mammals and humans. ...
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The synaptic vesicle protein CSP alpha prevents presynaptic degeneration
(CELL PRESS, 2004-04-22)
Cysteine string protein α (CSPα)—an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40 chaperones—is thought to regulate Ca2+ channels and/or synaptic vesicle exocytosis. We now show ...
Artículo
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Comparative analysis for the presence of IgG anti-aquaporin-1 in patients with NMO-Spectrum disorders
(MDPI AG, 2016-07-23)
Detection of IgG anti-Aquaporin-4 (AQP4) in serum of patients with Neuromyelitis optica syndrome disorders (NMOSD) has improved diagnosis of these processes and differentiation from Multiple sclerosis (MS). Recent findings ...