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Mostrando ítems 251-260 de 332
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Long-term immunosuppression for CNS mouse xenotransplantation: Effects on nigrostriatal neurodegeneration and neuroprotective carotid body cell therapy
(Wiley, 2018)
Abstract Background: The use of long-term immunosuppressive treatments on neural trans plantation has been controversial during the last decades. Although nowadays there is a consensus about the necessity of maintaining ...
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Depolarizing response of rat parathyroid cells to divalent cations
(1983)
Membrane potentials were recorded from rat parathyroid glands continuously perfused in vitro. At 1 .5 mM external Ca", the resting potential averages -73 ± 5 mV (mean ± SD, n = 66). On exposure to 2.5 mM Ca", the cells ...
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Autoevaluación con refuerzo, como herramienta informática infividual de apoyo en el aprendizaje
(Universidad de Sevilla, 1998)
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Efficacy and safety clinical trial with efavirenz in patients diagnosed with adult Niemann-pick type C with cognitive impairment
(Lippincott, Williams & Wilkins, 2022-12-02)
Background: Niemann-Pick disease Type C (NPC) is a genetic, incurable, neurodegenerative disorder. This orphan disease is most frequently caused by mutations in the NPC1 protein, resulting in intralysossomal cholesterol ...
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Editorial: A Compendium of Recent Research on Stem Cell-Based Therapy for Covid-19
(Frontiers Media, 2021-12-14)
We have been dealing with an unprecedented global health crisis for nearly 2 years now. This started after an outbreak of atypical pneumonia of unknown etiology that was described in late December 2019 in China’s Wuhan ...
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A normative modelling approach reveals age-atypical cortical thickness in a subgroup of males with autism spectrum disorder
(Nature Portfolio, 2020)
Understanding heterogeneity is an important goal on the path to precision medicine for autism spectrum disorders (ASD). We examined how cortical thickness (CT) in ASD can be parameterized as an individualized metric of ...
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Cellular adaptation to oxygen deficiency beyond the Nobel award
(Willey, 2020)
Understanding the cellular adaptation to oxygen deficiency -hypoxia- has a profound impact on our knowledge of the pathogenesis of several diseases. The elucidation of the molecular machinery that regulates response to ...
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The Mitochondrial SDHD Gene Is Required for Early Embryogenesis, and Its Partial Deficiency Results in Persistent Carotid Body Glomus Cell Activation with Full Responsiveness to Hypoxia
(2004)
The SDHD gene encodes one of the two membrane-anchoring proteins of the succinate dehydrogenase (complex II) of the mitochondrial electron transport chain. This gene has recently been proposed to be involved in oxygen ...
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Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia
(American Society for Biochemistry and Molecular Biology, 2012-02-03)
Early adaptive responses to hypoxia are essential for cell survival, but their nature and underlying mechanisms are poorly known. We have studied the post-transcriptional changes in the proteome of mammalian cells elicited ...
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PKCα-Mediated Downregulation of RhoA Activity in Depolarized Vascular Smooth Muscle: Synergistic Vasorelaxant Effect of PKCα and ROCK Inhibition
(2019-02-18)
Background/Aims: Protein kinase C (PKC)- and RhoA/Rho-associated kinase (ROCK) play important roles in arterial sustained contraction. Although depolarization-elicited RhoA/ROCK activation is accepted, the role of PKC ...