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Mostrando ítems 231-240 de 332
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Acute oxygen sensing in heme oxygenase-2 null mice
(2006)
Hemeoxygenase-2 (HO-2) is an antioxidant enzyme that can modulate recombinant maxi-K+ channels and has been proposed to be the acute O2 sensor in the carotid body (CB). We have tested the physiological contribution of this ...
Artículo
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Functional and transcriptional induction of Aquaporin-1 gene by hypoxia; analysis of promoter and role of Hif-1α
(2011)
Aquaporin-1 (AQP1) is a water channel that is highly expressed in tissues with rapid O2 transport. It has been reported that this protein contributes to gas permeation (CO2, NO and O2) through the plasma membrane. We show ...
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miR-30b-5p Downregulation as a predictive biomarker of coronary in-stent restenosis
(2021-03-30)
In-stent restenosis (ISR) is one of the main limitations of percutaneous coronary intervention (PCI) therapy with drug-eluting stents (DES) implantation. The aim of this study was to determine if circulating microRNAs ...
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AQP1 and AQP4 Contribution to Cerebrospinal Fluid Homeostasis
(MDPI, 2019-02-24)
Aquaporin 1 (AQP1), expressed in epithelial cells of the choroid plexus, and aquaporin 4 (AQP4) present in ependymal cells and glia limitants have been proposed to play a significant role in cerebrospinal fluid (CSF) ...
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Gene expression profiling supports the neural crest origin of adult rodent carotid body stem cells and identifies CD10 as a marker for mesectoderm-committed progenitors
(WILEY, 2016)
Neural stem cells (NSCs) are promising tools for understanding nervous system plasticity and repair, but their use is hampered by the lack of markers suitable for their prospective isolation and characterization. The carotid ...
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Conservative and disruptive modes of adolescent change in human brain functional connectivity
(National Academy of Sciences, 2020)
Adolescent changes in human brain function are not entirely understood. Here, we used multiecho functional MRI (fMRI) to measure developmental change in functional connectivity (FC) of resting-state oscillations between ...
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Intraoperative mapping of executive function using electrocorticography for patients with low-grade gliomas
(Springer, 2020-11-22)
Background Intraoperative functional mapping with direct electrical stimulation during awake surgery for patients with diffuse low-grade glioma has been used in recent years to optimize the balance between surgical resection ...
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Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice
(Nature Publishing Group, 2022)
Aging in mammals leads to reduction in genes encoding the 45-subunit mitochondrial electron transport chain complex I. It has been hypothesized that normal aging and age-related diseases such as Parkinson’s disease are ...
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2-hydroxyglutarate metabolism is altered in an in vivo model of LPS induced endotoxemia
(Frontiers Media, 2020)
The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) ...
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Currents recorded through small areas of squid axon membrane with an internal virtual ground voltage clamp
(1981)
A new voltage-clamp apparatus for the squid axon has been implemented to enable recording of currents through small areas of axon membrane. The performance of this clamp was tested by recording total sodium currents from ...