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Clinical feasibility study of gold nanoparticles as theragnostic agents for precision radiotherapy.
(MDPI, 2022)
Background: Gold nanoparticles (AuNP) may be useful in precision radiotherapy and disease monitoring as theragnostic agents. In diagnostics, they can be detected by computerized tomography (CT) because of their higher ...
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The Childhood-Onset Neurodegeneration with Cerebellar Atrophy (CONDCA) Disease Caused by AGTPBP1 Gene Mutations: The Purkinje Cell Degeneration Mouse as an Animal Model for the Study of this Human Disease
(MDPI, 2021-09-04)
Recent reports have identified rare, biallelic damaging variants of the AGTPBP1 gene that cause a novel and documented human disease known as childhood-onset neurodegeneration with cerebellar atrophy (CONDCA), linking loss ...
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Delayed administration of ixazomib modifies the immune response and prevents chronic graft-versus-host disease
(Nature Publishing Group, 2021-09-23)
In this study, we aimed to modify the immune response in the long term after allogeneic bone marrow transplantation (allo-BMT) by using the proteasome inhibitor ixazomib (IXZ) at the late stages of the post-transplant ...
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Global Evolution of Pathogenic Bacteria With Extensive Use of Fluoroquinolone Agents
(Frontiers Media, 2020)
It is well-established that the spread of many multidrug-resistant (MDR) bacteria is predominantly clonal. Interestingly the international clones/sequence types (STs) of most pathogens emerged and disseminated during the ...
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Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages
(NATURE PUBLISHING GROUP, 2021-07-22)
Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which ectopic ...
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Synaptic defects in spinal muscular atrophy animal models
(Wiley, 2011)
Proximal spinal muscular atrophy, the most frequent genetic cause of childhood lethality, is caused by homozygous loss or mutation of the SMN1 gene on human chromosome 5, which codes for the survival motor neuron (SMN) ...
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Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice
(2008)
Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 in the regulation of neuronal apoptosis. To better understand this function in vivo, we have created PHD3_/_ ...
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miR-200c-3p, miR-222-5p, and miR-512-3p Constitute a Biomarker Signature of Sorafenib Effectiveness in Advanced Hepatocellular Carcinoma
(MDPI, 2022-08-28)
Background: Sorafenib constitutes a suitable treatment alternative for patients with advanced hepatocellular carcinoma (HCC) in whom atezolizumab + bevacizumab therapy is contraindicated. The aim of the study was the ...
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Grey and white matter microstructure is associated with polygenic risk for schizophrenia
(Nature Publishing Group, 2021-08-30)
Recent discovery of approximately 270 common genetic variants associated with schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population. We hypothesized that normal variation in PRS would be ...
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Prenatal treatment with rapamycin restores enhanced hippocampal mGluR‑LTD and mushroom spine size in a Down’s syndrome mouse model
(BioMed Central Ltd, 2021)
Down syndrome (DS) is the most frequent genetic cause of intellectual disability including hippocampal-dependent memory defcits. We have previously reported hippocampal mTOR (mammalian target of rapamycin) hyperactiva‑ tion, ...