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Editorial: Regulatory T cells in graft versus host disease
(Frontiers Media, 2023-02-20)
Regulatory T cells (Tregs) are modulators of the immune system that play a key role in maintaining self-tolerance. Treg were initially identified by Sakaguchi as CD4+CD25+ T cells that have the ability to suppress autoimmune ...
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Genetic, cellular, and connectomic characterization of the brain regions commonly plagued by glioma
(Oxford University Press, 2020)
For decades, it has been known that gliomas follow a non-random spatial distribution, appearing more often in some brain regions (e.g. the insula) compared to others (e.g. the occipital lobe). A better understanding of the ...
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BOLD Coupling between Lesioned and Healthy Brain Is Associated with Glioma Patients’ Recovery
(MDPI, 2021-10-06)
Predicting functional outcomes after surgery and early adjuvant treatment is difficult due to the complex, extended, interlocking brain networks that underpin cognition. The aim of this study was to test glioma functional ...
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SOS GEFs in health and disease
(Elsevier, 2020)
SOS1 and SOS2 are the most universal and widely expressed family of guanine exchange factors (GEFs) capable or activating RAS or RAC1 proteins in metazoan cells. SOS proteins contain a sequence of modular domains that are ...
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Robustness of PET Radiomics Features: Impact of Co-Registration with MRI
(MDPI, 2021-10-30)
Radiomics holds great promise in the field of cancer management. However, the clinical application of radiomics has been hampered by uncertainty about the robustness of the features extracted from the images. Previous ...
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El sistema endógeno de serotonina no participa en la abstinencia opiácea, aunque su inhibición por estimulación del receptor 5-HT1A incrementa la eficacia antidisfórica de la clonidina en ratas
(2003)
El objetivo del estudio fue discernir el papel del sistema endógeno de serotonina en la abstinencia opiácea, tanto en su vertiente somática como emocional, así como su posible interacción con los efectos de la clonidina. Con ...
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Using redox-sensitive fluorescent probes to record real-time reactive oxygen species production in cells from mouse carotid body slices
(Cell Press, 2021)
Reactive oxygen species (ROS) are important signaling molecules for physiologic processes such as acute response to hypoxia. However, reliable real-time ROS measurement in cells has been a long-standing methodological ...
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A deep graph neural network architecture for modelling spatio-temporal dynamics in resting-state functional MRI data
(Elsevier Science B.V, 2022)
Resting-state functional magnetic resonance imaging (rs-fMRI) has been successfully employed to understand the organisation of the human brain. Typically, the brain is parcellated into regions of interest (ROIs) and modelled ...
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Trasplante de células naturales "dopaminotróficas" nuevo concepto terapeútico antiparkinsoniano
(Viguera, 2003)
Aim and method. Parkinson's disease is caused by the degeneration of dopamineric neurons of substantia nigra projecting to striatum. Cellular substitution represents a potentially treatment once beneficial levodopa effects ...
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Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy
(Springer Nature, 2022)
Anxiety and depression affect 35–50% of patients with Parkinson’s disease (PD), often precede the onset of motor symptoms, and have a negative impact on their quality of life. Dysfunction of the serotonergic (5-HT) system, ...