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Listar Artículos (Fisiología Médica y Biofísica) por autor "López Barneo, José"
Mostrando ítems 21-40 de 70
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First aid kit for hypoxic survival: sensors and strategies
López Barneo, José; Nurse, C.A.; Nilsson, G.E.; Buck, L.T.; Gassmann, M.; Bogdanova, A. Yu. (University of Chicago Press, 2010)Survival success under conditions of acute oxygen deprivation depends on efficiency of the central and peripheral ...
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Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate
Villadiego Luque, Francisco Javier; García-Arriaza, Juan; Ramírez Lorca, Reposo; García Swinburn, Roberto; Cabello Rivera, Daniel; Rosales Nieves, Alicia E.; Muñoz Cabello, Ana María; López Barneo, José; Toledo Aral, Juan José (Nature Publishing Group, 2023)Vaccines against SARS-CoV-2 have been shown to be safe and effective but their protective efficacy against infection in ...
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Functional and transcriptional induction of Aquaporin-1 gene by hypoxia; analysis of promoter and role of Hif-1α
Abreu Rodríguez, Irene; Sánchez Silva, Rocío; Martins, Ana Paula; Soveral, Graça; Toledo Aral, Juan José; López Barneo, José; Echevarría Irusta, Miriam (2011)Aquaporin-1 (AQP1) is a water channel that is highly expressed in tissues with rapid O2 transport. It has been reported ...
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Gating of O2-sensitive K + Channels of Arterial Chemoreceptor Cells and Kinetic Modifications Induced by Low PO2
Ganfornina, María Dolores; López Barneo, José (1992)We have studied the kinetic properties of the O2-sensitive K+ channels (KO2 channels) of dissociated glomus cells from ...
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Gene expression analyses reveal metabolic specifications in acute O-2-sensing chemoreceptor cells
Gao Chen, Lin; Bonilla Henao, Victoria; García-Flores, Paula; Arias-Mayenco, Ignacio; Ortega Sáenz, Patricia; López Barneo, José (Wiley, 2017-09)Acute O2sensing is a fundamental property of cells in the peripheral chemoreceptors,e.g. glomus cells in the carotid body ...
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Gene expression profiling supports the neural crest origin of adult rodent carotid body stem cells and identifies CD10 as a marker for mesectoderm-committed progenitors
Navarro Guerrero, Elena; Platero-Luengo, Aida; Linares Clemente, Pedro; Cases, Ildefonso; López Barneo, José; Pardal Redondo, Ricardo (WILEY, 2016)Neural stem cells (NSCs) are promising tools for understanding nervous system plasticity and repair, but their use is ...
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Glucose sensing by carotid body glomus cells: potential implications in disease
Gao Chen, Lin; Ortega Sáenz, Patricia; García Fernández, María; González Rodríguez, Patricia; Caballero Eraso, Candela; López Barneo, José (Frontiers Media, 2014-10-15)The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. ...
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HIF-2a is essential for carotid body development and function
Macías, David; Cowburn, Andrew S.; Torres Torrelo, Hortensia; Ortega Sáenz, Patricia; López Barneo, José; Johnson, Randall S (eLife Sciences Publications, 2018-04-19)Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations ...
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Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1
March Diaz, Rosana; Lara Ureña, Nieves; Romero Molina, Carmen; Heras Garvin, Antonio; Ortega de San Luis, Clara; Alvarez Vergara, Maria I.; Navarro Garrido, Victoria; Sánchez Mico, María Victoria; Vizuete Chacón, María Luisa; López Barneo, José; Vitorica Ferrández, Francisco Javier; Pascual, Alberto (Springer, 2021)Genetic Alzheimer’s disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), ...
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Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells
Ureña López, Juan; Fernández-Chacón, Rafael; Rodríguez Benot, Alberto; Álvarez de Toledo Naranjo, Guillermo; López Barneo, José (1994)We have investigated the changes of cytosolic [Ca2+1 and the secretory -activity in single glomus cells dispersed from ...
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Identification and Functional Characterization of a K1 Channel a- Subunit with Regulatory Properties Specific to Brain
Castellano Orozco, Antonio Gonzalo; Chiara, María D.; Mellström, Britt; Molina, Antonio; Monje Quiroga, Francisco; Naranjo, José R.; López Barneo, José (1997)The physiological diversity of K1 channels mainly depends on the expression of several genes encoding different a-subunits. ...
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Ionic currents in dispersed chemoreceptor cells of the mammalian carotid body
Ureña López, Juan; López López, J.; González Montelongo, M. Carmen; López Barneo, José (1989)Ionic currents of enzymatically dispersed type I and type II cells of the carotid body have been studied using the whole ...
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Is Carotid Body Infection Responsible for Silent Hypoxemia in COVID-19 Patients?
Villadiego Luque, Francisco Javier; Ramírez Lorca, Reposo; Cala, Fernando; Labandeira-García, José L.; Esteban, Mariano; Toledo Aral, Juan José; López Barneo, José (Oxford University Press (OUP), 2021) -
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Lactate sensing mechanisms in arterial chemoreceptor cells
Torres-Torrelo, Hortensia; Ortega Sáenz, Patricia; López Barneo, José (2021)Classically considered a by-product of anaerobic metabolism, lactate is now viewed as a fundamental fuel for oxidative ...
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Low pO2 selectively inhibits K channel activity in chemoreceptor cells of the mammalian carotid body
López López, J.; González Montelongo, M. Carmen; Ureña López, Juan; López Barneo, José (1989)The hypothesis that changes in environmental O2 tension (pO2) could affect the ionic conductances of dissociated type I ...
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MECHANISMS OF DISEASE Acute Oxygen-Sensing Mechanisms
E. Kenneth Weir, M.D.; López Barneo, José; Buckler, Keith J.; Stephen L. Archer, M.D (Massachusetts Medical Society, 2005)JOSEPH PRIESTLEY, ONE OF THE THREE SCIENTISTS CREDITED WITH THE discovery of oxygen, described the death of mice that were ...
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Metabotropic Ca2+ channel-induced Ca2+ release and ATP-dependent facilitation of arterial myocyte contraction
Valle Rodríguez, Alberto del; Calderón Sánchez, Eva María; Ruiz Pérez, Myriam; Ordóñez Guerrero, Antonio; López Barneo, José; Ureña López, Juan (2006)Voltage-gated Ca2_ channels in arterial myocytes can mediate Ca2_ release from the sarcoplasmic reticulum and, thus, induce ...
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Mitochondrial Complex I Function Is Essential for Neural Stem/Progenitor Cells Proliferation and Differentiation
Cabello Rivera, Daniel; Sarmiento Soto, Helia; López Barneo, José; Muñoz Cabello, Ana María (Frontiers Research Foundation, 2019)Neurogenesis in developing and adult mammalian brain is a tightly regulated process that relies on neural stem cell (NSC) ...
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Molecular mechanisms of acute oxygen sensing by arterial chemoreceptor cells. Role of Hif2α
Ortega Sáenz, Patricia; Moreno Domínguez, Alejandro; Gao Chen, Lin; López Barneo, José (Frontiers Research Foundation, 2020)Carotid body glomus cells are multimodal arterial chemoreceptors able to sense and integrate changes in several physical ...
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Molecular targets for endogenous glial cell line-derived neurotrophic factor modulation in striatal parvalbumin interneurons
Enterría-Morales, Daniel; López-González del Rey, Natalia; Blesa, Javier; López-López, Ivette; Gallet, Sarah; Prévot, Vincent; López Barneo, José; D'Anglemont De Tassigny, Xavier (Oxford University Press, 2020)Administration of recombinant glial cell line-derived neurotrophic factor into the putamen has been tested in preclinical ...