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Artículo
The spatial pattern of exocytosis and post-exocytic mobility of synaptopHluorin in mouse motor nerve terminals
(Wiley, 2009-03)
We monitored the spatial distribution of exo- and endocytosis at 37◦C in mouse motor nerve terminals expressing synaptopHluorin (spH), confirming and extending earlier work at room temperature, which had revealed fluorescent ...
Artículo
Collapse of conductance Is prevented by a Glutamate residue conserved in voltage-dependent K+ channels
(2000)
Voltage-dependent K 1 channel gating is influenced by the permeating ions. Extracellular K 1 determines the occupation of sites in the channels where the cation interferes with the motion of the gates. When external [K 1] ...
Artículo
Acute oxygen sensing in heme oxygenase-2 null mice
(2006)
Hemeoxygenase-2 (HO-2) is an antioxidant enzyme that can modulate recombinant maxi-K+ channels and has been proposed to be the acute O2 sensor in the carotid body (CB). We have tested the physiological contribution of this ...
Tesis Doctoral
Hipoxia en cardiomiocitos; regulación de la expresión de la subunidad b1 del canal maxi-k y participación en el precondicionamiento cardíaco
(2009-03-09)
The presence of maxi-K channels has been reported in the mitochondria of the cardiac myocytes where it plays a cytoprotective role. Using real-time PCR we have observed that severe chronic hypoxia induces the down-regulation ...
Artículo
Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression
(Elsevier, 2007)
O2 is essential for aerobic life, and the classic view is that it diffuses freely across the plasma membrane. However, measurements of O 2 permeability of lipid bilayers have indicated that it is much lower than previously ...
Artículo
Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium
(2000)
We have developed a thin-slice preparation of whole rat carotid body that allows us to perform patch-clamp recording of membrane ionic currents and to monitor catecholamine secretion by amperometry in single glomus cells ...
Artículo
The Mitochondrial SDHD Gene Is Required for Early Embryogenesis, and Its Partial Deficiency Results in Persistent Carotid Body Glomus Cell Activation with Full Responsiveness to Hypoxia
(2004)
The SDHD gene encodes one of the two membrane-anchoring proteins of the succinate dehydrogenase (complex II) of the mitochondrial electron transport chain. This gene has recently been proposed to be involved in oxygen ...
Tesis Doctoral
Tesis Doctoral
Quimiorrecepción del CO2 en la médula adrenal y facilitación de la permeabilidad a O2 por la acuaporina-1
(2007-02-02)
El desarrollo de esta Tesis se ha centrado en el estudio de los mecanismos celulares que permiten la quimiotransducción de O2 y CO2 en órganos como el cuerpo carotídeo y la médula adrenal. Teniendo en cuenta las evidencias ...