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Mostrando ítems 11-18 de 18
Artículo
Collapse of conductance Is prevented by a Glutamate residue conserved in voltage-dependent K+ channels
(2000)
Voltage-dependent K 1 channel gating is influenced by the permeating ions. Extracellular K 1 determines the occupation of sites in the channels where the cation interferes with the motion of the gates. When external [K 1] ...
Tesis Doctoral
Hipoxia en cardiomiocitos; regulación de la expresión de la subunidad b1 del canal maxi-k y participación en el precondicionamiento cardíaco
(2009-03-09)
The presence of maxi-K channels has been reported in the mitochondria of the cardiac myocytes where it plays a cytoprotective role. Using real-time PCR we have observed that severe chronic hypoxia induces the down-regulation ...
Artículo
Sodium and Calcium Currents in Dispersed Mammalian Septal Neurons
(1991)
Voltage-gated Na+ and Ca2+ conductances of freshly dissociated septal neurons were studied in the whole-cell configuration of the patch-clamp technique. All cells exhibited a large Na+ current with characteristic fast ...
Artículo
Prolyl Hydroxylase-dependent Modulation of Eukaryotic Elongation Factor 2 Activity and Protein Translation under Acute Hypoxia
(American Society for Biochemistry and Molecular Biology, 2012-02-03)
Early adaptive responses to hypoxia are essential for cell survival, but their nature and underlying mechanisms are poorly known. We have studied the post-transcriptional changes in the proteome of mammalian cells elicited ...
Artículo
PKCα-Mediated Downregulation of RhoA Activity in Depolarized Vascular Smooth Muscle: Synergistic Vasorelaxant Effect of PKCα and ROCK Inhibition
(2019-02-18)
Background/Aims: Protein kinase C (PKC)- and RhoA/Rho-associated kinase (ROCK) play important roles in arterial sustained contraction. Although depolarization-elicited RhoA/ROCK activation is accepted, the role of PKC ...
Artículo
Changes in adhesion and the expression of adhesion molecules in PBMCs after aneurysmal subarachnoid hemorrhage: relation to cerebral vasospasm
(Springer, 2023)
Aneurysmal subarachnoid hemorrhage (aSAH) is a neurovascular disease produced by extravasation of blood to the subarachnoid space after rupture of the cerebral vessels. After bleeding, the immune response is activated. The ...
Artículo
Artículo
Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion
(Frontiers Research Foundation, 2018-07-03)
Aims: Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R) injuries. However, little is known about its role in the regulation of intracellular Ca2+ concentration ([Ca2+]i) under I/R. Here, ...