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Mostrando ítems 1-10 de 26
Artículo
Protection and repair of the nigrostriatal pathway with stem-cell-derived carotid body glomus cell transplants in chronic MPTP Parkinsonian model
(MDPI, 2023-03-14)
Antiparkinsonian carotid body (CB) cell therapy has been proven to be effective in rodent and nonhuman primate models of Parkinson’s disease (PD), exerting trophic protection and restoration of the dopaminergic nigrostriatal ...
Artículo
Resistance of subventricular neural stem cells to chronic hypoxemia despite structural disorganization of the germinal center and impairment of neuronal and oligodendrocyte survival
(Dove Medical Press Ltd., 2015)
Chronic hypoxemia, as evidenced in de-acclimatized high-altitude residents or in patients with chronic obstructive respiratory disorders, is a common medical condition that can produce serious neurological alterations. ...
Artículo
Tesis Doctoral
Estudio de la familia de proteínas Rho GTPasas en la biología del neuroblastoma
(2022-07-14)
El neuroblastoma (NB) es el tumor extracraneal sólido de aparición más común durante la edad pediátrica. El NB surge a raíz de un desarrollo erróneo del linaje simpatoadrenal de la cresta neural. Es una enfermedad muy ...
Capítulo de Libro
A pathophysiological view of the neural stem cell niche
(Nova Science Publishers, INC. U.S., 2011)
Neural stem cells were described in the nervous system some decades ago as being responsible for adult neurogenesis and hence the structural plasticity in the tissue. These cells reside in specialized niches where they are ...
Artículo
Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells
(Wiley-Blackwell Publishing Ltd., 2003)
Carotid body glomus cells release transmitters in response to hypoxia due to the increase of excitability resulting from inhibition of O2 -regulated K+ channels. However, the mechanisms involved in the detection of changes ...
Tesis Doctoral
Papel de la quinasa humana VRK1 en la biología del neuroblastoma
(2020-01-29)
El neuroblastoma es el tumor extracraneal sólido más frecuente en la infancia. Su comportamiento es muy heterogéneo, pudiéndose dar desde regresión espontánea hasta tumores metastásicos muy agresivos. Uno de los ...
Artículo
The carotid body, a neurogenic niche in the adult peripheral nervous system
(Univ pisa, 2010)
We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the peripheral nervous system. These progenitor cells support neurogenesis in vivo in response to ...
Artículo
The carotid body: a physiologically relevant germinal niche in the adult peripheral nervous system
(Springer, 2018-11-29)
Oxygen constitutes a vital element for the survival of every single cell in multicellular aerobic organisms like mammals. A complex homeostatic oxygen-sensing system has evolved in these organisms, including detectors and ...
Tesis Doctoral
Hipertrofia del cuerpo carotídeo en hipoxia crónica: mecanismos de activación, proliferación y diferenciación de los progenitores neurales en el sistema nervioso periférico
(2014-04-25)
The goal of this doctoral thesis is to achieve a better understanding of the biology and behavior of the recently discovered adult carotid body neural stem cells. The work focuses on two main objectives. First, to study ...