Buscar
Mostrando ítems 11-20 de 26
Artículo
Neurotransmitter Modulation of Carotid Body Germinal Niche
(MDPI AG, 2020-11-03)
The carotid body (CB), a neural-crest-derived organ and the main arterial chemoreceptor in mammals, is composed of clusters of cells called glomeruli. Each glomerulus contains neuron-like, O2-sensing glomus cells, which ...
Artículo
Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats
(2003)
We studied the mechanisms underlying long-term functional recovery of hemiparkinsonian rats grafted intrastriatally with carotid body (CB) cell aggregates. Amelioration of their motor syndrome is a result of the trophic ...
Artículo
Analysis of serial neuroblastoma PDX passages in mice allows the identification of new mediators of neuroblastoma aggressiveness
(MDPI, 2023-01-13)
Neuroblastoma is a neural crest cell-derived pediatric tumor characterized by high interand intra-tumor heterogeneity, and by a poor outcome in advanced stages. Patient-derived xenografts (PDXs) have been shown to be ...
Artículo
An O-2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hipoxia
(CELL PRESS, 2014-01-16)
Neural stem cells (NSCs) exist in germinal centers of the adult brain and in the carotid body (CB), an oxygen-sensing organ that grows under chronic hypoxemia. How stem cell lineage differentiation into mature glomus cells ...
Tesis Doctoral
Plasticidad fisiológica de las células madre del cuerpo carotídeo adulto: caracterización del linaje mesectodérmico
(2015-07-01)
El cuerpo carotídeo (CB), un órgano quimiosensor derivado de la cresta neural, permite la adaptación a la hipoxia crónica mediante neurogénesis y angiogénesis. Recientemente se ha descrito en nuestro grupo que ambos procesos ...
Capítulo de Libro
Progenitor Cell Heterogeneity in the Adult Carotid Body Germinal Niche
(Springer, 2019)
Somatic stem cells confer plasticity to adult tissues, permitting their maintenance, repair and adaptation to a changing environment. Adult germinal niches supporting somatic stem cells have been thoroughly characterized ...
Artículo
Carotid body oxygen sensing and adaptation to hipoxia
(Springer, 2015-09)
The carotid body (CB) is the principal arterial chemoreceptor that mediates the hyperventilatory response to hypoxia. Our understanding of CB function and its role in disease mechanisms has progressed considerably in the ...
Artículo
Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body
(Cell Press, 2017)
Adult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been amatter of debate in the last decade. Neural-crest-derived stem cells (NCSCs) ...
Artículo
Neural crest derived progenitor cells contribute to tumor stroma and aggressiveness in stage 4/M neuroblastoma
(Impact Journals, 2017)
Pediatric tumors arise upon oncogenic transformation of stem/progenitor cells during embryonic development. Given this scenario, the existence of non-tumorigenic stem cells included within the aberrant tumoral niche, ...
Artículo
Collapse of conductance Is prevented by a Glutamate residue conserved in voltage-dependent K+ channels
(2000)
Voltage-dependent K 1 channel gating is influenced by the permeating ions. Extracellular K 1 determines the occupation of sites in the channels where the cation interferes with the motion of the gates. When external [K 1] ...