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Mostrando ítems 1-10 de 18
Artículo
Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
(Public Library of Science, 2016-07-25)
One of the most fascinating properties of the brain is the ability to function smoothly across decades of a lifespan. Neurons are nondividing mature cells specialized in fast electrical and chemical communication at ...
Artículo
Novel SCAMPs Lacking NPF Repeats: Ubiquitous and Synaptic Vesicle-Specific Forms Implicate SCAMPs in Multiple Membrane- Trafficking Functions
(2000)
In vertebrates, secretory carrier membrane proteins (SCAMPs) 1–3 constitute a family of putative membrane-trafficking proteins composed of cytoplasmic N-terminal sequences with NPF repeats, four central transmembrane regions ...
Artículo
Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2
(2003)
We tested the long-standing hypothesis that synaptotagmin 1 is the Ca2 +_ sensor for fast neurosecretion by analyzing the intracellular Ca 2+ dependence of large dense-core vesicle exocytosis in a mouse strain carrying a ...
Artículo
Rab3D Is Not Required for Exocrine Exocytosis but for Maintenance of Normally Sized Secretory Granules
(2002)
Rab3D, a member of the Rab3 subfamily of the Rab/ypt GTPases, is expressed on zymogen granules in the pancreas as well as on secretory vesicles in mast cells and in the parotid gland. To shed light on the function of Rab3D, ...
Artículo
Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells
(1994)
We have investigated the changes of cytosolic [Ca2+1 and the secretory -activity in single glomus cells dispersed from rabbit carotid bodies during exposure to solutions with variable 02 tension (Po2). In normoxic conditions ...
Artículo
Oxygen sensing by ion channels and chemotransduction in single glomus cells
(1996)
We have monitored cytosolic [Ca2+] and dopamine release in intact fura-2-loaded glomus cells with microfluoroimetry and a polarized carbon fiber electrode. Exposure to low PO2 produced a rise of cytosolic [Ca2+] with two ...
Artículo
CSP alpha-deficiency causes massive and rapid photoreceptor degeneration
(2006)
Cysteine string protein (CSP) _ is an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40-type cochaperones. Previous studies showed that deletion of CSP_ in mice leads to massive lethal ...
Artículo
Structure/Function Analysis of Ca2 + Binding to the C2A Domain of Synaptotagmin 1
(2002)
Synaptotagmin 1, a Ca2+ sensor for fast synaptic vesicle exocytosis, contains two C2 domains that form Ca2+ -dependent complexes with phospholipids. To examine the functional importance of Ca2+ binding to the C2A domain ...
Artículo
Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease
(2011)
In Huntington’s disease (HD), the expansion of polyglutamine (polyQ) repeats at the N terminus of the ubiquitous protein huntingtin (htt) leads to neurodegeneration in specific brain areas. Neurons degenerating in HD develop ...
Artículo
A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss
(Wiley-Blackwell Publishing Ltd., 2016)
Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limbgirdle muscular dystrophy, we ...