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Mostrando ítems 11-18 de 18
Artículo
Cysteine String Protein- Prevents Activity-Dependent Degeneration in GABAergic Synapses
(2010)
The continuous release of neurotransmitter could be seen to place a persistent burden on presynaptic proteins, one that could compromise nerve terminal function. This supposition and the molecular mechanisms that might ...
Tesis Doctoral
Identificación de una firma inmunohistoquímica con valor predictivo en el carcinoma infiltrante de mama de tipo no especial (NST)
(2015-05-28)
Introducción: En la actualidad, el cáncer de mama es la neoplasia maligna más común en la mujer, siendo la causa principal de muerte en mujeres entre los 35 y 55 años en todo el mundo. La identificación en el cáncer de ...
Tesis Doctoral
Single‐cell transcriptomic and functional characterization of cortical parvalbumin interneurons in a novel conditional knock‐out mouse lacking CSPα/DNAJC5
(2019-07-05)
Neurodegenerative diseases are progressive disorders currently without cure. Indeed, the molecular mechanisms underlying synaptic and neuronal degeneration are poorly understood. Cysteine String Protein‐α/DNAJC5 (CSPα/DNAJC5) ...
Artículo
Deletion of CASK in mice is lethal and impairs synaptic function
(2007)
CASK is an evolutionarily conserved multidomain protein composed of an N-terminal Ca2_/calmodulin-kinase domain, central PDZ and SH3 domains, and a C-terminal guanylate kinase domain. Many potential activities for CASK ...
Artículo
The synaptic vesicle protein CSP alpha prevents presynaptic degeneration
(CELL PRESS, 2004-04-22)
Cysteine string protein α (CSPα)—an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40 chaperones—is thought to regulate Ca2+ channels and/or synaptic vesicle exocytosis. We now show ...
Artículo
Monitoring synaptic function at the neuromuscular junction of a mouse expressing synaptopHluorin
(2007)
We monitored presynaptic exocytosis and vesicle recycling at neuromuscular junctions of transgenic mice expressing synaptopHluorin (spH), using simultaneous optical and electrophysiological recordings. Synaptic transmission ...
Tesis Doctoral
Presynaptic calcium dynamics, neuronal excitability and synaptic vesicle Cycle in central synapses lacking cysteine string protein-alpha (CSP-ALPHA).
(2017-12-22)
Cysteine String Protein-α (CSP-α) is a molecular co-chaperone of the synaptic vesicles that prevents presynaptic degeneration. The role of CSP-α in the machinery of calcium dependent release of neurotransmitter from synaptic ...
Tesis Doctoral
Estudio del papel de CSPa/DNAJC5 en la función y mantenimiento de las sinapsis glutamatérgicas del hipocampo en ratones adultos
(2023-07-14)
La cochaperona sináptica Cysteine String Protein CSP /DNAJC5) se ha implicado en la patogénesis de enfermedades neurodegenerativas como la lipofuscinosis neuronal ceroidea autosómica dominante del adulto (enfermedad de ...