Artículos (Farmacología): Recent submissions
Now showing items 41-60 of 223
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Article
Dietary Manipulation of Amino Acids for Cancer Therapy
(MDPI, 2023)Cancer cells cannot proliferate and survive unless they obtain sufficient levels of the 20 proteinogenic amino acids (AAs). ...
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Repurposing Study of 4-Acyl-1-phenylaminocarbonyl-2-substituted-piperazine Derivatives as Potential Anticancer Agents-In Vitro Evaluation against Breast Cancer Cells
(MDPI, 2023)first_pagesettingsOrder Article Reprints Open AccessArticle Repurposing Study of 4-Acyl-1-phenylaminocarbonyl-2-substituted-piperazine ...
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Perfluorohexyloctane in dry eye disease: A systematic review of its efficacy and safety as a novel therapeutic agent
(Elsevier, 2023)Perfluorohexyloctane (F6H8), a physically and chemically inert synthetic compound, has recently emerged as a promising ...
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Article
Potential interactions between pangenotypic direct-acting antivirals and concomitant cardiovascular therapies in patients with chronic hepatitis C virus infection
(SAGE Publications, 2020)To identify potential drug interactions (DIs) between pangenotypic direct-acting antivirals (pDAAs) and concomitant cardiovascular (CV) therapies in patients with chronic hepatitis C (CHC).
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Article
Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb/C Pristane-Induced Mice
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)Systemic lupus erythematosus (SLE) is a chronic immune-inflammatory disease characterized by multiorgan affectation and ...
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Article
Rhythm and ROS: Hepatic Chronotherapeutic Features of Grape Seed Proanthocyanidin Extract Treatment in Cafeteria Diet-Fed Rats
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)Polyphenols play a key role in the modulation of circadian rhythms, while the cafeteria diet (CAF) is able to perturb the ...
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Article
Xanthigen® reduces lipid deposition and improves stress resistance in Caenorhabditis elegans
(eSciPub LLC, 2020)Xanthigen® is a nutraceutical combination of two well-known natural products, brown seaweed extract (rich in fucoxanthin) ...
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Patient experience evaluation of the CMO-based pharmaceutical care model vs usual care in people living with HIV
(Dove Medical Press Ltd, 2022)Objective: To compare patient experience in a real-life population of people living with HIV (PLWH) who received pharmaceutical ...
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Article
Up-Regulation of the Nrf2/HO-1 Antioxidant Pathway in Macrophages by an Extract from a New Halophilic Archaea Isolated in Odiel Saltworks
(MDPI, 2023): The production of reactive oxygen species (ROS) plays an important role in the progression of many inflammatory diseases. ...
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Photoperiod Conditions Modulate Serum Oxylipins Levels in Healthy and Obese Rats: Impact of Proanthocyanidins and Gut Microbiota
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)Seasonal rhythms are emerging as a key factor influencing gut microbiota and bioactive compounds functionality as well as ...
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Article
DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
(Elsevier, 2023)Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic ...
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Article
Artificial Diets with Altered Levels of Sulfur Amino Acids Induce Anticancer Activity in Mice with Metastatic Colon Cancer, Ovarian Cancer and Renal Cell Carcinoma
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)Sulfur-containing amino acids methionine (Met), cysteine (Cys) and taurine (Tau) are common dietary constituents with ...
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Article
Artificial Diets with Selective Restriction of Amino Acids and Very Low Levels of Lipids Induce Anticancer Activity in Mice with Metastatic Triple-Negative Breast Cancer
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)Current treatments for patients with metastatic triple negative breast cancer (TNBC) are generally ineffective. This ...
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Article
Phytochemical Analysis and Anti-Inflammatory Potential of Acanthus mollis L. Rhizome Hexane Extract
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)The rhizomes of Acanthus mollis have traditionally been used for the treatment of several ailments involving inflammation. ...
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Impact of Frailty on Outcomes of First-Line Pembrolizumab Monotherapy in a Real-World Population with Advanced Non-Small Cell Lung Cancer
(MDPI, 2023)ICIs have been able to improve overall survival in advanced-stage lung cancer. The benefit of this therapy is limited in ...
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Population pharmacokinetics and pharmacodynamics of fosfomycin in non-critically ill patients with bacteremic urinary infection caused by multidrug-resistant Escherichia coli
(Elsevier, 2018)Objectives: To describe the population pharmacokinetics of fosfomycin for patients with bacteraemic urinary tract infection ...
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Manipulation of Amino Acid Levels with Artificial Diets Induces a Marked Anticancer Activity in Mice with Renal Cell Carcinoma
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Targeted therapies with antiangiogenic drugs (e.g., sunitinib) and immune checkpoint inhibitors (e.g., anti-PD-1 antibodies) ...
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9-PAHPA long term intake in DIO and db/db mice ameliorates insulin sensitivity but has few effects on obesity and associated metabolic disorders
(Elsevier, 2023)Branched fatty acid esters of hydroxy fatty acids are endogenous lipids reported to have antidiabetic and anti-inflammatory ...
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Article
Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Previously, we reported that MTH1 inhibitors TH588 and TH1579 selectively induce oxidative damage and kill Ras-expressing ...
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Article
Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination
(Elsevier, 2017)Zebularine is a second-generation, highly stable hydrophilic inhibitor of DNA methylation with oral bioavailability that ...