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Artículo
Curcumin as a DNA Topoisomerase II Poison
(Taylor & Francis Open Access, 2003)
Curcumin, the major active component of the spice turmeric, is recognised as a safe compound with great potential for cancer chemoprevention and cancer therapy. It induces apoptosis, but its initiation mechanism remains ...
Artículo
Iridoids as DNA topoisomerase I poisons
(Taylor & Francis Open Access, 2005)
The discovery of new topoisomerase I inhibitors is necessary since most of the antitumor drugs are targeted against type II and only a very few can specifically affect type I. Topoisomerase poisons generate toxic DNA ...
Artículo
Flavonoids As DNA Topoisomerase I Poisons
(Taylor & Francis Open Access, 2002)
The therapeutic anticancer potential of flavonoids shown by recent research needs a greater understanding of these compounds. They are antioxidants and antimutagenic agents that can inhibit tumor promotion and transformation ...