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Artículo
New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum Asbestinum
(MDPI, 2020)
Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a ...
Artículo
Screening for selective anticancer activity of 65 extracts of plants collected in Western Andalusia, Spain
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Finding cytotoxic drugs with a high selectivity towards cancer cells is crucial to improve the low survival rates of patients diagnosed with metastatic cancers. Since plants are an important source of anticancer drugs, we ...
Patente. Invención
Composición de gel de aloe e hidroxitirosol
(Oficina Española de Patentes y Marcas (OEPM), 2020-04-03)
Composición farmacéutica o nutracéutica que comprende entre un 90-99,9% de polvo de gel de aloe y un 0,1%-10% de Hidroxitirosol; caracterizada porque el polvo de gel de aloe no contiene aloína. Uso de la composición ...
Artículo
Preparation, characterization and evaluation of the anti-inflammatory activity of epichlorohydrin-β-cyclodextrin/curcumin binary systems embedded in a pluronic® /hyaluronate hydrogel
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Curcumin (Cur) is an anti-inflammatory polyphenol that can be complexed with polymeric cyclodextrin (CD) to improve solubility and bioavailability. The aim of the present work was to prepare a CurCD hydrogel to treat ...
Artículo
Polyphenolic Extract (PE) from Olive Oil Exerts a Potent Immunomodulatory Effect and Prevents Graft-versus-Host Disease in a Mouse Model
(Elsevier, 2020)
Polyphenols are a group of chemical substances found in plants, with immunomodulatory, antiproliferative, and anti-inflammatory properties that might be useful in the prophylaxis and treatment of graft-versus-host disease ...
Tesis Doctoral
Artículo
Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases
(MDPI, 2020)
Iridoids, which have beneficial health properties, include a wide group of cyclopentane [c] pyran monoterpenoids present in plants and insects. The cleavage of the cyclopentane ring leads to secoiridoids. Mainly, secoiridoids ...
Artículo
Dual Role of Phenyl Amides from Hempseed on BACE 1, PPARγ, and PGC-1α in N2a-APP Cells
(American Chemical Society, 2021)
n Alzheimer’s disease (AD) the accumulation of amyloid β (Aβ) plaques in the brain leads to neuroinflammation, neuronal cell dysfunction, and progressive memory loss. Therefore, blocking the formation of Aβ plaques has ...
Artículo
Anticancer Activities of Meroterpenoids Isolated from the Brown Alga Cystoseira usneoides against the Human Colon Cancer Cells HT-29
(MDPI, 2020)
Colorectal cancer (CRC) is one of the most common types of cancers and a leading cause of cancer death worldwide. The current treatment for CRC mainly involves surgery, radiotherapy, and chemotherapy. However, due to the ...
Artículo
Remdesivir and mortality reduction in COVID-19 patients: a systematized subgroup analysis of clinical trials
(Sociedad Española de Farmacia Hospitalaria, 2021)
Objective: Remdesivir has not shown survival benefit for patients with severe COVID-19. However, subgroup analysis of ACTT-1 Study Group showed an apparent reduction in mortality for patients who required non-high-flow ...