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Artículo
Preparation, characterization and evaluation of the anti-inflammatory activity of epichlorohydrin-β-cyclodextrin/curcumin binary systems embedded in a pluronic® /hyaluronate hydrogel
Autor/es | Fernández Romero, Ana María
Maestrelli, Francesca García Gil, Sara Talero Barrientos, Elena Mª Mura, Paola Angela Rabasco Álvarez, Antonio María González Rodríguez, María Luisa |
Departamento | Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica Universidad de Sevilla. Departamento de Farmacología |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-10-14 |
Publicado en |
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Resumen | Curcumin (Cur) is an anti-inflammatory polyphenol that can be complexed with polymeric cyclodextrin (CD) to improve solubility and bioavailability. The aim of the present work was to prepare a CurCD hydrogel to treat ... Curcumin (Cur) is an anti-inflammatory polyphenol that can be complexed with polymeric cyclodextrin (CD) to improve solubility and bioavailability. The aim of the present work was to prepare a CurCD hydrogel to treat inflammatory skin conditions. Epichlorohydrin-β-CD (EpiβCD) was used as polymeric CD. To characterize the binary system, solid-state and in-solution studies were performed. Afterwards, an experimental design was performed to optimize the hy-drogel system. Finally, the CurEpiβCD hydrogel system was tested for anti-inflammatory activity using a HaCat psoriasis cell model. Co-grinded Cur/EpiβCD binary system showed a strong interaction and Curcumin solubility was much improved. Its combination with Pluronic® F-127/hyalu-ronate hydrogel demonstrated an improvement in release rate and Curcumin permeation. After testing its anti-inflammatory activity, the system showed a significant reduction in IL-6 levels. Hy-drogel-containing CurEpiβCD complex is a great alternative to treat topical inflammatory diseases. |
Agencias financiadoras | Junta de Andalucía |
Identificador del proyecto | CTS214
CTS658 |
Cita | Fernández Romero, A.M., Maestrelli, F., García Gil, S., Talero Barrientos, E.M., Mura, P.A., Rabasco Álvarez, A.M. y González Rodríguez, M.L. (2021). Preparation, characterization and evaluation of the anti-inflammatory activity of epichlorohydrin-β-cyclodextrin/curcumin binary systems embedded in a pluronic® /hyaluronate hydrogel. International Journal of Molecular Sciences, 22 (24), 13566. https://doi.org/10.3390/ijms222413566. |
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