Artículos (Farmacia y Tecnología Farmacéutica)

URI permanente para esta colecciónhttps://hdl.handle.net/11441/11020

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Nanomedicina: ¿nuevo abordaje terapeutico en el manejo de la trombosis?
(Asociación de Neumólogos del Sur, 2021) Vázquez Tavero, M. I.; Cayero Otero, María Dolores; Arellano Orden, Elena; Martín Banderas, Lucía; Otero Candelera, Remedios; Farmacia y Tecnología Farmacéutica; Medicina
Avatrombopag plus fostamatinib combination as treatment in patients with multirefractory immune thrombocytopenia
(John Wiley & Sons, Inc., 2024-10) Mingot Castellano, María Eva; Bastida, José María; Ghanima, Waleed; Ruiz Sainz, Elena; Núñez Vázquez, Ramiro José; Pedrote Amador, Bergoña; Abdel-Kader Martín, Laila; Piquer Monsonis, Dolores; Canaro, Mariana; Medicina; Farmacia y Tecnología Farmacéutica; CTS410: Epidemiología del Cáncer
Immune thrombocytopenia (ITP) refractory to multiple therapies may require a combination of drugs targeting different mechanisms and targets. In this retrospective, multicentre, international study, we report the safety and effectiveness of avatrombopag and fostamatininb in combination administered to 18 patients with multirefractory ITP. Overall, the combination response was achieved in 15 patients (83.3%), with a median time from combination start to best response of 15 days (IQR: 8–35 days). After a median follow-up of 256 days (IQR: 142.8–319), 5 patients relapsed (26.7%), all during tapering or stopping one drug. Adverse events were described in 6 of 18 patients (33%).
Genome-Wide DNA Methylation Markers Associated With Metabolic Liver Cancer
(Elsevier, 2025) Antwi, Samuel O.; Darko Jnr. Siaw, Ampem; Armasu, Sebastian M.; Frank, Jacob A.; Yan, Irene K.; Ahmed, Fowsiyo Y.; Izquierdo-Sánchez, Laura; Rojas, Ángela; Romero Gómez, Manuel; Patel, Tushar; Farmacia y Tecnología Farmacéutica; Medicina; National Institutes of Health. United States
Metabolic liver disease is the fastest-rising cause of hepatocellular carcinoma (HCC), but the underlying molecular processes that drive HCC development in the setting of metabolic perturbations are unclear. We investigated the role of aberrant DNA methylation in metabolic HCC development in a multicenter international study. METHODS: We used a case-control design, frequency-matched on age, sex, and study site. Genome-wide profiling of peripheral blood leukocyte DNA was performed using the 850k EPIC array. The study sample was split 80% and 20% for training and validation. Cell type proportions were estimated from the methylation data. Differential methylation analysis was performed adjusting for cell type, generating area under the receiver-operating characteristic curves (AUC-ROC). RESULTS: We enrolled 272 metabolic HCC patients and 316 control patients with metabolic liver disease from 6 sites. Fifty-five differentially methylated CpGs were identified; 33 hypermethylated and 22 hypomethylated in cases vs controls. The panel of 55 CpGs discriminated between the cases and controls with AUC ¼ 0.79 (95% confidence interval [CI] ¼ 0.71–0.87), sensitivity ¼ 0.77 (95% CI ¼ 0.66–0.89), and specificity ¼ 0.74 (95% CI ¼ 0.64–0.85). The 55-CpG classifier panel performed better than a base model that comprised age, sex, race, and diabetes mellitus (AUC ¼ 0.65, 95% CI ¼ 0.55–0.75; sensitivity ¼ 0.62, 95% CI ¼ 0.49–0.75; and specificity ¼ 0.64, 95% CI ¼ 0.52–0.75). A multifactorial model that combined the 55 CpGs with age, sex, race, and diabetes yielded AUC ¼ 0.78 (95% CI ¼ 0.70–0.86), sensitivity ¼ 0.81 (95% CI ¼ 0.71–0.92), and specificity ¼ 0.67 (95% CI ¼ 0.55–0.78). CONCLUSION: A panel of 55 blood leukocyte DNA methylation markers differentiates patients with metabolic HCC from control patients with benign metabolic liver disease, with a slightly higher sensitivity when combined with demographic and clinical information.
Advanced Optimization of Clonazepam-Loaded Solid Self-Emulsifying Drug Delivery Systems: Comparison of Weighted Goal Programming and Desirability Function in a Quality by Design Framework
(Multidisciplinary Digital Publishing Institute (MDPI), 2026-02-28) González Rodríguez, María Luisa; Valverde Cabeza, Sonia; Pérez Terrón, Enrique; Rabasco Álvarez, Antonio María; González Rodríguez, Pedro Luis; Farmacia y Tecnología Farmacéutica; Organización Industrial y Gestión de Empresas I
Background/Objectives: Clonazepam (CLZ), a BCS Class II drug, presents significant oral delivery challenges due to its low aqueous solubility. This study explores the systematic development of solid self-emulsifying drug delivery systems (S-SEDDS) using Quality by Design (QbD). The primary objective was to evaluate and compare advanced mathematical optimization frameworks, specifically Derringer’s Desirability Function (D) and Weighted Goal Programming (WGP), to identify a robust formulation that enhances drug solubilization while ensuring superior processability and flowability. Methods: Liquid SEDDS were solidified by adsorption onto a porous matrix (Aerosil® 200/Lactose). A multi-objective optimization was conducted to define a robust Design Space (DS), comparing D against WGP. The trade-offs between competing Critical Quality Attributes (CQAs), specifically powder flowability (angle of repose, AR), blending efficiency (BE), and CLZ recovery (CR), were evaluated. Characterization included morphology from Environmental Scanning Electron Microscopy (ESEM), droplet size analysis, and pH-dependent dissolution studies. Results: D provided a highly robust baseline, yielding constant optimal coordinates (F2, F3 = +1; F4 = 0) across all sensitivity levels, with a predicted AR of 40.46°, BE of 0.12 and CR of 90.0%. However, WGP successfully refined this solution by allowing a more flexible weighting of goals, achieving a more favorable compromise with an AR of 38.96°, a BE of 0.11, and a CR of 90.23%. The optimized system maintained nanometric droplet sizes (<200 nm) and showed a controlled, pH-independent release profile, reaching 80% drug solubilization at 6 h. Conclusions: Integrating WGP into the QbD framework offers a more versatile and precise optimization than the traditional D for complex pharmaceutical systems. This approach ensures the production of high-quality S-SEDDS, bridging the gap between mathematical modeling and the stringent requirements of industrial solid dosage manufacturing.
Empowering Women in Pharmacy History Through Digital Heritage: ICT-Based Teaching Innovation and Social Engagement at the Museum of History of Pharmacy of Seville (Spain)
(MDPI, 2026-02-28) Ramos Carrillo, Antonio; Ruiz Altaba, Rocío; Farmacia y Tecnología Farmacéutica
This study analyses the educational and social impact of a series of innovative teaching projects developed at the Museum of the History of Pharmacy of the University of Seville. The initiatives—including historical video documentaries, the “student guides” programme, and the digital outreach project “Voices that Empower”—explore the pedagogical potential of scientific heritage as a learning tool and as a medium for public communication. Through experiential and service-learning methodologies, these projects have enhanced students’ communication skills, critical thinking, and awareness of cultural and gender dimensions within pharmaceutical studies. The results demonstrate that the integration of audiovisual production, museum-based learning, and digital storytelling fosters meaningful engagement between the university and society, while also revitalising the historical and humanistic dimensions of pharmacy. Furthermore, the inclusion of a gender perspective in the “Voices that Empower” initiative contributes to the visibility of women in STEM and highlights the museum as a space for empowerment and social transformation. This work concludes that university museums can act as strategic platforms for innovation in higher education, combining heritage preservation, teaching excellence, and civic outreach to promote a more inclusive and sustainable scientific culture.
¿Se sabe con seguridad quién fue la primera mujer farmacéutica de la historia?
(Real e Ilustre Colegio Oficial de Farmacéuticos, 2020-01-15) Núñez Valdés, Juan; Ramos Carrillo, Antonio; Geometría y Topología
Aunque los datos que se encuentran en algunas fuentes, fundamentalmente digitales, no sean falsos, ocurre algunas veces que no están suficientemente precisados o bien que el contexto en el que se enmarcan no está convenientemente aclarado, lo cual puede producir mucha confusión en los investigadores. Esto suele suceder, por ejemplo, cuando se trata de saber quiénes fueron las primeras personas, las pioneras, de alguna actividad. En este artículo se aclaran varias imprecisiones que se desprenden de algunas fuentes consultadas con relación a la pregunta de quién fue la primera mujer licenciada en Farmacia de la historia.
The hepatitis C Virus modulates insulin signaling pathway in vitro promoting insulin resistance
(Public Library of Science (PLoS, 2012-10-25) del Campo, José A.; García-Valdecasas, Marta; Rojas, Lourdes; Rojas, Ángela; Romero Gómez, Manuel; Farmacia y Tecnología Farmacéutica; Medicina; Instituto de Salud Carlos III
Insulin is critical for controlling energy functions including glucose and lipid metabolism. Insulin resistance seems to interact with hepatitis C promoting fibrosis progression and impairing sustained virological response to peginterferon and ribavirin. The main aim was to elucidate the direct effect of hepatitis C virus (HCV) infection on insulin signaling both in vitro analyzing gene expression and protein abundance. Huh7.5 cells and JFH-1 viral particles were used for in vitro studies. Experiments were conducted by triplicate in control cells and infected cells. Genes and proteins involved in insulin signaling pathway were modified by HCV infection. Moreover, metformin treatment increased gene expression of PI3K, IRS1, MAP3K, AKT and PTEN more than >1.5 fold. PTP1B, encoding a tyrosin phosphatase, was found highly induced (>3 fold) in infected cells treated with metformin. However, PTP1B protein expression was reduced in metformin treated cells after JFH1 infection. Other proteins related to insulin pathway like Akt, PTEN and phosphorylated MTOR were also found down-regulated. Viral replication was inhibited in vitro by metformin. A strong effect of HCV infection on insulin pathway-related gene and protein expression was found in vitro. These results could lead to the identification of new therapeutic targets in HCV infection and its co-morbidities.
Las hermanas Figueroa Marty, primeras mujeres cubano-españolas licenciadas en Farmacia
(Real e Ilustre Colegio Oficial de Farmacéuticos, 2023) Núñez Valdés, Juan; Ruiz Altaba, Rocío; Moreno Toral, Esteban; Ramos Carrillo, Antonio; Geometría y Topología
En este artículo se muestran las biografías de Eloísa y María Dolores Figueroa Marty, dos hermanas cubanas de quienes puede decirse que, salvando algunos matices, fueron las primeras mujeres españolas licenciadas en Farmacia, en 1886, ya que, a pesar de no haber nacido en la península, lo hicieron en Cuba, territorio que en aquel momento se encontraba bajo dominación española. El objetivo es sacar a la luz sus figuras y ponerlas como ejemplos de la presencia de la mujer en la farmacia en la actualidad. Se incluyen también algunas notas sobre la Botica Francesa de Matanzas, en Cuba.
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C
(Nature publishing group; Nature portfolio; Springer Science and Business Media LLC, 2016-09-15) Thabet, K; Asimakopoulos, A; Shojaei, M; Romero Gómez, Manuel; Mangia, Alessandra; Irving, WL; Berg, T; Rojas, Ángela; Eslam, Mohammed; International Liver Disease Genetics Consortium; Gallego Durán, Rocío; Medicina; Farmacia y Tecnología Farmacéutica; Deutsche Forschungsgemeinschaft / German Research Foundation (DFG); Gobierno egipcio; Fundación Héctor; Programa del Consejo Nacional de Salud e Investigación Médica de Australia (NHMRC); Beca del NHMRC; Fondo Novo Nordisk; Fundación NOVO Nordisk y Consejo Danés de Investigación Estratégica; Legado de Robert W. Storr a la Fundación Médica de Sídney; Universidad de Sídney
Cirrhosis likely shares common pathophysiological pathways despite arising from a variety of liver diseases. A recent GWAS identified rs641738, a polymorphism in the MBOAT7 locus, as being associated with the development of alcoholic cirrhosis. Here we explore the role of this variant on liver inflammation and fibrosis in two cohorts of patients with chronic hepatitis C. In 2,051 patients, rs641738 associated with severe hepatic inflammation and increased risk of fibrosis, as well as fast fibrosis progression. At functional level, rs641738 associated with MBOAT7 transcript and protein levels in liver and blood, and with serum inflammatory, oxidative stress and macrophage activation markers. MBOAT7 was expressed in immune cell subsets, implying a role in hepatic inflammation. We conclude that the MBOAT7 rs641738 polymorphism is a novel risk variant for liver inflammation in hepatitis C, and thereby for liver fibrosis.
A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-beta 1 dependent mechanisms
(Nature publishing group; Nature portfolio; Springer Science and Business Media LLC, 2019-02-05) Sharkawy, Rasha El; Bayoumi, Ali; Metwally, Mayada; Mangia, Alessandra; Berg, Thomas; Romero Gómez, Manuel; Gallego Durán, Rocío; Rojas, Ángela; Jonsson, Julie R.; Medicina; Farmacia y Tecnología Farmacéutica; Beca del Programa de Capacitación en Investigación (RTP) del Gobierno de Australia; Deutsche Forschungsgemeinschaft / German Research Foundation (DFG); Egyptian government; Hector-Foundation; Subvención del Programa del Consejo Nacional de Salud e Investigación Médica de Australia (NHMRC); Beca del NHMRC; Robert W. Storr Bequest
Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients. The role of these variants on hepatic inflammation and fibrosis that are closely associated with HCC development is not known, nor are the biological mechanisms underlying their impact on the liver. Here, we demonstrate in 1689 patients with chronic hepatitis C (CHC) (1,501 with CHC and 188 with HCV-related HCC), that the MICA (T) allele, despite not being associated with HCC susceptibility, is associated with increased fibrosis stage (OR: 1.47, 95% CI: 1.05-2.06, p = 0.02) and fibrosis progression rate (hazards ratio: 1.41, 95% CI: 1.04-1.90, p = 0.02). The DEPDC5 variant was not associated with any of these phenotypes. MICA expression was down-regulated in advanced fibrosis stages. Further, (T) allele carriage was associated with lower MICA expression in liver and serum. Transforming growth factor-β1 (TGF-β1) expression suppresses MICA expression in hepatic stellate cells. Our findings suggest a novel mechanism linking susceptibility to advanced fibrosis and subsequently indirectly to HCC, to the level of MICA expression through TGF-β1-dependent mechanisms.
A new deferiprone controlled release system obtained by ultrasound-assisted compression
(Taylor & Francis, 2014) Aguilar de Leyva, Mercedes Ángela; Gonçalves-Araujo, Tamara; Daza, Verónica; Caraballo Rodríguez, Isidoro; Farmacia y Tecnología Farmacéutica
Objectives: This study implements the design of an innovative dosage form using ultrasound-assisted compression of thermoplastic polymers and the development of controlled release tablets for the oral administration of deferiprone in two doses per day. Methods: Binary matrix tablets containing deferiprone and thermoplastic polymers have been prepared using an ultrasound-assisted tableting machine. Scanning electron microscopy has been employed to determine a sintering phenomenon of the excipients. Water uptake and drug release studies have been carried out to evaluate the ability of the polymers to control the drug release. Results: SEM micrographs showed that some polymers underwent the sintering process and the in vitro dissolution test showed good fit of the release data from these tablets to the zero-order kinetic model. Conclusions: Carbopol 974P and 971P have been selected as matrix forming polymers for the final formulation. The polymer percolation threshold has been exceeded with 15% w/w of polymer. Therefore, sustained release tablets have been developed with only 15% of excipient. This implies that matrix tablets containing 750 mg of API, intended for two administrations a day, can be obtained with a similar weight to those existing in the market containing 500 mg of API for three administrations a day.
Study of the properties of the new biodegradable polyurethane PU (TEG-HMDI) as matrix forming excipient for controlled drug delivery
(Taylor & Francis, 2013) Campiñez, María Dolores; Aguilar de Leyva, Mercedes Ángela; Ferris, Cristina; Paz Báñez, María Violante de; Galbis Pérez, Juan Antonio; Caraballo Rodríguez, Isidoro; Farmacia y Tecnología Farmacéutica; Química Orgánica y Farmacéutica
The purpose of this work is to study the ability of a new biodegradable polyurethane PU(TEG-HMDI) obtained by reaction of triethylene glycol (TEG) with 1,6-hexamethylene diisocyanate (HMDI) to act as matrix forming polymer for controlled release tablets and to estimate its percolation threshold in a matrix system. Matrix tablets weighing 250 mg were prepared by direct compression with 10–30% wt/wt of PU(TEG-HMDI) and anhydrous theophylline as model drug. Release studies were carried out using the paddle method. The results were analyzed using the kinetics models of Higuchi, Korsmeyer-Peppas, and Peppas and Sahlin. These studies confirm the existence of an excipient percolation threshold between 10 and 20 % wt/wt of PU(TEG-HMDI) for the different batches prepared. It has been observed that the new biodegradable polyurethane PU(TEG-HMDI) shows adequate compatibility as well as a high ability to control the drug release.
Subretinal Transplant of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium on Nanostructured Fibrin-Agarose
(SAGE Publications, 2019-11-04) García Delgado, Ana Belén; De la Cerda, Berta; Alba Amador, Julia; Valdés Sánchez, Maria Lourdes; Fernández Muñoz, Beatriz; Relimpio López, Isabel; Rodríguez de la Rúa Franch, Enrique; Díaz Corrales, Francisco J.; Farmacia y Tecnología Farmacéutica; Cirugía; Junta de Andalucía; European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)
Damage to the retinal pigment epithelium (RPE) in age‐related macular degeneration (AMD) and other diseases results in photoreceptor cell death and blindness. Replacement of RPE is therefore being explored as a therapy for several retinal diseases. To move towards a future personalized autologous transplant approach, we have prepared a biocompatible implant using RPE derived from induced pluripotent stem cells (iPSC) reprogrammed from a healthy donor´s monocytes. The correct positioning of the polarized RPE is essential to fulfill its role and protect photoreceptors from degeneration. Hence, we have used a biocompatible hydrogel matrix of fibrin and agarose (FAH) that allows the surgical placement of an RPE sheet in the subretinal space, keeping its functional orientation. Our aim was to demonstrate safety and viability of the transplant in preclinical models. Pigs were used to test the feasibility of a regular vitreo‐retinal surgery. Our results show that this implant is suitable for subretinal transplantation allowing human RPE cells to survive and maintain their phenotype and orientation without any local or systemic adverse events. The ability to transplant the iPSC‐derived RPE sheet in its natural orientation will surely increase the chance to obtain a therapeutic effect in future translational studies.
Systematic evaluation of subgroup analyses of inhaled treprostinil in pulmonary hypertension due to interstitial lung disease
(Public Library of Science (PLoS), 2025-02-12) Martínez Puig, Pablo; Báez Gutiérrez, Nerea; Rodríguez Ramallo, Héctor; Abdel-Kader Martín, Laila; Otero Candelera, Remedios; Farmacia y Tecnología Farmacéutica; Medicina
Background The INCREASE trial introduced a novel therapeutic option for Pulmonary Hypertension caused by Interstitial Lung Disease. Subsequently to this trial, several subgroup analyses were conducted, aiming to explore specific effects within subgroups. Objective This study aimed to evaluate the subgroup analyses performed in the INCREASE trial and to identify potentially reliable subgroup effects. Methods A methodological assessment of the subgroup analyses was performed. Claims of subgroup effect were evaluated using three different tools: Sun, X et al. 2012, Gil-Sierra, M.D et al2020, and Schandelmaier, S et al. 2020. Additionally, all statistically significant subgroup effects that were not claimed by the authors were evaluated. Results Five claims of subgroup effect were identified; none of them achieved statistical significance when assessed using an interaction test. The evaluation conducted with the three tools consistently yielded very low credibility for all the claims. During the assessment, a statistically significant subgroup effect of moderate credibility was identified, which the authors did not claim: iTre appeared to improve exercise capacity exclusively in patients with Pulmonary Vascular Resistance ⋝ 4 WUs. Conclusions Due to methodological limitations, the credibility of subgroup claims from the authors of the INCREASE was lacking and, therefore, should not be relied upon to inform decisions on an individual basis.
Generation of the human iPSC line ESi148-A from a patient with sporadic amyotrophic lateral sclerosis
(Elsevier, 2026) Garcia-Delgado, A.B.; Bega, S.; Campos-Cuerva, R.; Martín-Banderas, L.; Paradas, C.; Fernández Muñoz, Beatriz; Farmacia y Tecnología Farmacéutica; Ministerio de Ciencia, Innovación y Universidades (MICIU). España; Agencia Estatal de Investigación. España; Instituto de Salud Carlos III
Nearly 90% of patients with amyotrophic lateral sclerosis (ALS) do not carry mutations in genes previously associated with the disease and are classified as sporadic cases with no identified genetic cause. In this study, peripheral blood mononuclear cells from a patient with sporadic ALS were reprogrammed to generate the human induced pluripotent stem cell (iPSC) line ESi148-A. The line was thoroughly characterized for pluripotency and genomic stability. These cells provide a valuable resource for generating 3D biomodels, such as cortical or spinal cord organoids, to investigate disease mechanisms and develop novel therapeutic approaches for sporadic ALS.
Comparison of diagnostic performance of GAAD, GALAD, and ASAP scores for detecting hepatocellular carcinoma in advanced liver fibrosis patients
(De Gruyter, 2026-01-15) Izquierdo-Martínez, Alberto; Rojas, Ángela; Rubio-Sánchez, Ricardo; Dominguez-Pascual, Inmaculada; Romero Gómez, Manuel; Medicina; Farmacia y Tecnología Farmacéutica
Objectives Alpha-fetoprotein L3 (AFP-L3 %) and protein induced by vitamin K absence-II (PIVKA-II) are used in diagnostic scores such as GAAD, GALAD, and ASAP for hepatocellular carcinoma (HCC) detection. Advanced liver fibrosis (ALF) is diagnosable by the liver fibrosis index and could be combined with these blood biomarkers for better HCC detection. Methods This study developed an analytical framework to address the role of GAAD, GALAD, and ASAP in ALF patients as a risk score to predict HCC. By analyzing data from 21 HCC and 30 ALF patients, this analysis assessed the diagnostic accuracy of individual biomarkers, ASAP, GAAD, and GALAD. Results GAAD slightly outperformed AFP (sensitivity: 76.2 %, specificity: 88.5 %). The combination of AFP and PIVKA-II also surpassed AFP alone. PIVKA-II and AFP-L3 showed the worst performance for identifying HCC. Conclusions GAAD and ASAP showed comparable or slightly superior performance to AFP, suggesting potential for screening strategies that should be confirmed in larger studies.
A new biodegradable polythiourethane as controlled release matrix polymer
(Elsevier, 2015-03-01) Campiñez, M. D.; Ferris Villanueva, Cristina; Paz Báñez, María Violante de; Aguilar de Leyva, Mercedes Ángela; Galbis Pérez, Juan Antonio; Caraballo Rodríguez, Isidoro; Química Orgánica y Farmacéutica; Farmacia y Tecnología Farmacéutica; Ministerio de Economía y Competitividad (MINECO). España
The main aim of this paper is the synthesis and characterization of a new linear functional biodegradable polythiourethane-d,l-1,4-dithiothreitol-hexamethylene diisocyanate [PTU(DTT-HMDI)]. The SeDeM diagram has been obtained to investigate its suitability to be processed through a direct compression process. Furthermore, the ability of this polymer to act as controlled release matrix forming excipient has been studied. Four batches of matrices containing 10–40% of polymer and theophylline anhydrous as model drug have been manufactured. Release studies have been carried out using the paddle method and the polymer percolation threshold has been estimated. The principal parameters of the SeDeM Expert system, such as the parametric profile (mean radius) and the good compression index (IGC = 4.59) for the polymer are very close to the values considered as adequate for direct compression even with no addition of flow agents. Furthermore, the results of the drug release studies show a high ability of the polymer to control the drug release. The excipient percolation threshold has been estimated between 20% and 30% w/w of polymer.
Reduction-sensitive functionalized copolyurethanes for biomedical applications
(Royal Society of Chemistry, 2014) Ferris, Cristina; Paz Báñez, María Violante de; Aguilar de Leyva, Mercedes Ángela; Caraballo Rodríguez, Isidoro; Galbis Pérez, Juan Antonio; Química Orgánica y Farmacéutica; Farmacia y Tecnología Farmacéutica; Ministerio de Economía y Competitividad (MINECO). España
In the present paper we combine functionalization and biodegradation in the rational design of polymers that can be used as carrier systems for drug delivery in the colon. Functionalization of new polyurethanes (PUs) was achieved by thiol–ene coupling reactions, a simple and straightforward procedure included among the so-called click reactions, which are currently accepted as one of the most powerful tools in organic chemistry. Enhancement of the degradability of the new materials by the introduction of disulfide linkages into the polymer backbone has led to a new group of stimulusresponsive sugar-based polyurethanes able to be degraded by tripeptide glutathione under physiological conditions. Atomic Force Microscopy (AFM) on solid-supported multilayered dry polymer films— prepared by spin-coating from dimethylsulfoxide solutions—was used to study the morphology of the polymers and the degradation process in reductive environments. Matrix systems containing polymers selected according to their rheological properties were also investigated as modulated methotrexaterelease systems.
Implantable and injectable drug delivery systems for pain management
(Taylor and Francis, 2025-09-02) Lu, Y. J.; Essadki Aittaji, Ilyas; Gao, J. Q.; Abraham, A. M.; Anjani, Q. K.; Cobo González, A. B.; Iglesias-Martín, Fernando; Vora, L. K.; Millán Jiménez, Mónica; Larrañeta, Eneko; Domínguez Robles, Juan; Farmacia y Tecnología Farmacéutica; Ministerio de Ciencia, Innovación y Universidades (MICIU). España; Agencia Estatal de Investigación. España
Introduction: Pain is a widespread global health issue, significantly affecting quality of life and contributing to disability. It is estimated that between 20% and 30% of the global population suffer from some form of non-cancer chronic pain. Around 80% of surgical patients report postoperative acute pain, with less than 50% achieving adequate pain control. Despite these statistics, the management of pain still remains a significant challenge for clinicians, with many patients experiencing poorly controlled pain or adverse effects related to analgesic medication. Areas covered: This literature review outlines current pain management strategies, focusing on non-oral postoperative pain therapies, including injectable drug delivery systems (such as in situ forming implants, micro- and nano-based formulations) and implantable drug delivery systems. Emphasis is placed on solid implantable devices designed for sustained drug delivery, which can offer more efficient localized drug delivery at the pain site. Expert opinion: While pharmacological treatments, including oral opioids and nonsteroidal anti-inflammatory drugs, are commonly used, implantable controlled release systems are emerging as more effective alternatives. These systems provide localized pain relief with reduced systemic exposure, minimizing side effects, opioid use, and the risk of addiction, offering a promising solution for improved postoperative pain management.
La participación de farmacéuticos y médicos cubanos en las guerras de independencia de Cuba contra España
(Universidad de Sevilla, 2025-12-30) Núñez Valdés, Juan; Ruiz Altaba, Rocío; Moreno Toral, Esteban; Ramos Carrillo, Antonio; Geometría y Topología; Farmacia y Tecnología Farmacéutica
Este artículo demuestra la participación activa de médicos y farmacéuticos cubanos en las tres guerras de independencia contra España. Se destacan las contribuciones de la familia Figueroa Marty y de Mercedes Sirvén Pérez-Puelles. La investigación se basa en fuentes primarias consultadas en archivos oficiales cubanos y españoles. Los resultados evidencian su papel sanitario y patriótico en la causa independentista.

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