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Browsing Artículos (Bioquímica y Biología Molecular) by Author "Tabares, Lucía"
Now showing items 1-9 of 9
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Article
Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse
Ruiz Laza, Rocío; Cano, Raquel; Casañas, Juan José; Gaffield, Michael A.; Betz, William J.; Tabares, Lucía (SOC NEUROSCIENCE, 2011-02-09)Synchronous neurotransmitter releaseis a highly regulated processthattakes place at specializations atthe presynapticmembrane ...
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Article
Altered Intracellular Ca2+ Homeostasis in Nerve Terminals of Severe Spinal Muscular Atrophy Mice
Ruiz Laza, Rocío; Casañas, Juan José; Torres-Benito, Laura; Cano, Raquel; Tabares, Lucía (SOC NEUROSCIENCE, 2010)Low levels of survival motor neuron (SMN) protein result in spinal muscular atrophy (SMA), a severe genetic disease ...
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Article
Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy
Simon, Christian M.; Jablonka, Sibylle; Ruiz Laza, Rocío; Tabares, Lucía; Sendtner, Michael (OXFORD UNIV PRESS, 2010)Proximal spinal muscular atrophy (SMA) is caused by homozygous loss or mutation of the SMN1 gene on human chromosome 5. ...
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Article
CSPα, a molecular co-chaperone essential for short and long-term synaptic maintenance
López Ortega, Elena; Ruiz Laza, Rocío; Tabares, Lucía (Frontiers Media S.A., 2017-02-10)Cysteine string protein a (CSPα) is a vesicle protein located in the presynaptic terminal of most synapses. CSPα is an ...
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Article
Cysteine string protein-α is essential for the high calciumsensitivity of exocytosis in a vertebrate synapse
Ruiz Laza, Rocío; Casañas, J. J.; Südhof, T. C.; Tabares, Lucía (Wiley, 2008)Cysteine string protein (CSPa) is a synaptic vesicle protein present in most central and peripheral nervous system ...
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HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System
Bachiller, Sara; Roca Ceballos, María Angustias; García Domínguez, Irene; Pérez Villegas, Eva María; Martos Carmona, David; Pérez Castro, Miguel Ángel; Real Navarrete, Luis Miguel; Rosa, José Luis; Tabares, Lucía; Venero Recio, José Luis; Armengol, José Ángel; Carrión, Ángel Manuel; Ruiz Laza, Rocío (Springer, 2018-03-30)A missense mutation in HERC1 provokes loss of cerebellar Purkinje cells, tremor, and unstable gait in tambaleante (tbl) ...
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Article
Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1 alpha
Arnold, Anne Sophie; Gill, Jonathan; Christe, Martine; Ruiz Laza, Rocío; McGuirk, Shawn; St-Pierre, Julie; Tabares, Lucía; Handschin, Christoph (NATURE PUBLISHING GROUP, 2014-04-04)The neuromuscular junction (NMJ) exhibits high morphological and functional plasticity. In the mature muscle, the relative ...
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Article
Synaptic defects in spinal muscular atrophy animal models
Torres-Benito, Laura; Ruiz Laza, Rocío; Tabares, Lucía (Wiley, 2011)Proximal spinal muscular atrophy, the most frequent genetic cause of childhood lethality, is caused by homozygous loss ...
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Article
Treatment with trkC agonist antibodies delays disease progression in neuromuscular degeneration (nmd) mice
Ruiz Laza, Rocío; Lin, J.; Forgie, A.; Foletti, D.; Shelton, D.; Rosenthal, A.; Tabares, Lucía (OXFORD UNIV PRESS, 2005)Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a fatal autosomal recessive disorder seen in infants. ...