Browsing Artículos (Bioquímica y Biología Molecular) by Funding agency "Ministerio de Economía y Competitividad (MINECO). España"
Now showing items 1-20 of 20
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AICAR Stimulates the Pluripotency Transcriptional Complex in Embryonic Stem Cells Mediated by PI3K, GSK3β, and β-Catenin
(American Chemical Society, 2020)Pluripotent stem cells maintain the property of self-renewal and differentiate into all cell types under clear environments. ...
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Chronic Stress Alters the Expression Levels of Longevity-related Genes in the Rat Hippocampus
(Elsevier, 2016)The molecular mechanisms underlying the negative effects of psychological stress on cellular stress during aging and ...
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Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model
(Impact Journals, LLC, 2015)Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative ...
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Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease
(Frontiers Media, 2018)The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, ...
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Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury
(Oxford University Press, 2019-07-15)Microglia are activated after spinal cord injury (SCI), but their phagocytic mechanisms and link to neuroprotection remain ...
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Effects of foliar fertilization of biostimulants obtained from sewage sludge on olive yield
(Taylor & Francis, 2022)The objective of this study was to investigate the effect of foliar fertilization of two biostimulants (BS1 and BS2) ...
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Galectin‑3, a novel endogenous TREM2 ligand, detrimentally regulates infammatory response in Alzheimer’s disease
(Springer, 2019)Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of ...
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HERC 1 Ubiquitin Ligase Mutation Affects Neocortical, CA3 Hippocampal and Spinal Cord Projection Neurons: An Ultrastructural Study
(Frontiers Media, 2016)The spontaneous mutation tambaleante is caused by the Gly483Glu substitution in the highly conserved N terminal RCC1-like ...
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HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory
(Frontiers Media, 2020)Mutations in the human HERC1 E3 ubiquitin ligase protein develop intellectual disability. The tambaleante (tbl) mouse ...
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HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System
(Springer, 2018-03-30)A missense mutation in HERC1 provokes loss of cerebellar Purkinje cells, tremor, and unstable gait in tambaleante (tbl) ...
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Article
Inflammatory bowel disease induces pathologicalα-synucleinaggregation in the human gut and brain
(Wiley, 2024-01-16)Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous ...
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Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells
(BMC, 2020)BACKGROUND: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial ...
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Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease
(Frontiers Media, 2018)The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role ...
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PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
(Impact Journals, 2015)Due to its role in regulation of mitochondrial function, PGC1α is emerging as an important player in ageing and neurodegenerative ...
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Pre-fermentative addition of an enzymatic grape seed hydrolysate in warm climate winemaking. Effect on the differential colorimetry, copigmentation and polyphenolic profiles
(Elsevier, 2016-10-15)The effect of adding an enzymatic hydrolysate of grape seeds (EH-GS) during Syrah wine fermentation in a warm climate has ...
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Preliminary Studies of the Toxicity of Agaricus Bisporous Aqueous Enzymatic Extracts (AbAEE) In Rats
(Avens Publishing Group, 2018)The health benefits of extracts from Agaricus bisporus greatly extend its use as components of new functional foods for ...
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RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation
(Springer Nature, 2018)In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate ...
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Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour
(Elsevier, 2021-01-10)Apoptotic caspases are thought to play critical roles in elimination of excessive and non-functional synapses and removal ...
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The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior
(Frontiers Media S.A., 2022)In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an ...
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White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice
(MDPI, 2021)Liver fibrosis can be caused by non-alcoholic steatohepatitis (NASH), among other conditions. We performed a study to ...