Browsing Artículos (Bioquímica y Biología Molecular) by Title
Now showing items 183-202 of 222
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Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice
(BMC, 2020)Background The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes ...
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Should we open fire on microglia? Depletion models as tools to elucidate microglial role in health and alzheimer’s disease
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)Microglia play a critical role in both homeostasis and disease, displaying a wide variety in terms of density, functional ...
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SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons
(Springer Nature, 2018)Sirtuin 1 (SIRT1) activity is neuroprotective, and we have recently demonstrated its role in the retrograde degenerative ...
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Soluble phospho‑tau from Alzheimer’s disease hippocampus drives microglial degeneration
(Springer (part of Springer Nature): Springer Open Choice Hybrid Journals, 2016)The role of microglial cells in the development and progression of Alzheimer’s disease (AD) has not been elucidated. Here, ...
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Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke
(BioMed Central, 2016)Ischemic stroke (caused by thrombosis, embolism or vasoconstriction) lead to the recruitment and activation of immune cells ...
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STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction
(American Association for Cancer Research, 2020-10-26)Astrocytes are thought to play a pivotal role in coupling neural activity and cerebral blood flow. However, it has been ...
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Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
(Springer Nature, 2021)Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases ...
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Stress and inflammation: a detrimental combination in the development of neurodegenerative disease
(Smart Science and Technology, 2014)Chronic stress accelerates the appearance of some neurodegenerative disorders, such as Alzheimer’s disease and Parkinson´s ...
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Stress Increases Vulnerability to Inflammation in the Rat Prefrontal Cortex
(Society for Neuroscience, 2006)Inflammation could be involved in some neurodegenerative disorders that accompany signs of inflammation. However, because ...
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Study of the biochemical activity and plant growth promoting bacteria in soils polluted with oxyfluorfen
(Taylor and Francis Group, 2023-08-13)There is currently a great deal of information available about the toxic effects of oxyfluorfen on soil biochemical activity ...
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Sulforaphane reduces the chronic inflammatory immune response of human dendritic cells
(MDPI, 2023)Background: Sulforaphane (SFN) is an isothiocyanate of vegetable origin with potent antioxidant and immunomodulatory ...
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Synaptic defects in spinal muscular atrophy animal models
(Wiley, 2011)Proximal spinal muscular atrophy, the most frequent genetic cause of childhood lethality, is caused by homozygous loss ...
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Synthesis and Antioxidant Activity of Alkyl Nitroderivatives of Hydroxytyrosol
(MDPI AG, 2016)A series of alkyl nitrohydroxytyrosyl ether derivatives has been synthesized from free hydroxytyrosol (HT), the natural ...
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Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease
(2023)Background Alzheimer’s disease (AD) is a progressive multifaceted neurodegenerative disorder for which no disease-modifying ...
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TET2 Regulates the Neuroinflammatory Response in Microglia
(Elsevier, 2019)Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for ...
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The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior
(Frontiers Media S.A., 2022)In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an ...
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The combined partial knockdown of CBS and MPST genes induces inflammation, impairs adipocyte function-related gene expression and disrupts protein persulfidation in human adipocytes
(MDPI, 2022)Recent studies in mice and humans demonstrated the relevance of H2S synthesising enzymes, such as CTH, CBS, and MPST, in ...
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The Emerging Role of Senotherapy in Cancer: A Comprehensive Review
(MDPI, 2023-07-22)Senotherapy, a promising therapeutic strategy, has drawn a lot attention recently due to its potential for combating cancer. ...
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The HERC proteins and the nervous system
(Elsevier, 2021)The HERC protein family is one of three subfamilies of Homologous to E6AP C-terminus (HECT) E3 ubiquitin ligases. Six HERC ...