Instituto de Investigaciones Químicas (IIQ) – CIC Cartuja: Envíos recientes
Mostrando ítems 121-140 de 282
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Hu Antigen R (HuR) Protein Structure, Function and Regulation in Hepatobiliary Tumors
(MDPI, 2022)Hepatobiliary tumors are a group of primary malignancies encompassing the liver, the intra- and extra-hepatic biliary ...
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Trehalose-based Janus cyclooligosaccharides: the Click synthesis and DNA-directed assembly into pH-sensitive transfectious nanoparticles
(Royal Society of Chemistry, 2016)The convergent preparation of Janus molecular nanoparticles by thiourea-‘‘clicking’’ of a,a0 -trehalose halves has been ...
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Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases
(Royal Society of Chemistry, 2016)Lysosomal storage disorders (LSDs) are often caused by mutations that destabilize native folding and impair the trafficking ...
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Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B
(Wiley, 2020)Ligand-based NMRtechniquesto studyprotein–ligandinteractionsare potenttoolsin drugdesign.Satura-tiontransfer difference ...
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Ten years of FEBS Open Bio
(Wiley, 2021)This month, FEBS Open Bio celebrates its 10th birthday. To celebrate the journal's first decade, we present this special ...
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Lysosomes: multifunctional compartments ruled by a complex regulatory network
(Wiley, 2022)More than 50 years have passed since Nobel laureate Cristian de Duve described for the first time the presence of tiny ...
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ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs
(Springer, 2021)Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+) homeostasis. Using various biochemical approaches, ...
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Protonation of the Cysteine Axial Ligand Investigated in His/Cys c-Type Cytochrome by UV-Vis and Mid- And Far-IR Spectroscopy
(American Chemical Society, 2020)His/Cys coordination was recently found in several c-type cytochromes, which could act as sensors, in electron transport ...
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Entering the second decade: FEBS Open Bio in 2022
(Wiley-Blackwell, 2022)FEBS Open Bio continues to go from strength to strength, with 2021 perhaps marking its most exciting year. In this Editorial, ...
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The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract
(Public Library of Science, 2021)AU The:human Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly gut symbiont Ruminococcus gnavus displays strain-specific ...
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Membraneless organelles: a smart design for metabolic control
(Wiley Online Library, 2021)While most organelles are surrounded by membranes, cells also contain membraneless organelles, which remain separated in ...
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Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo
(MDPI, 2021)The uniqueness of paclitaxel’s antimitotic action mechanism has fueled research toward its application in more effective ...
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Inhibition of the PP2A activity by the histone chaperone ANP32B is long-range allosterically regulated by respiratory cytochrome c
(Elsevier, 2021)Repair of injured DNA relies on nucleosome dismantling by histone chaperones and de-phosphorylation events carried out by ...
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Synthesis, structure and midkine binding of chondroitin sulfate oligosaccharide analogues
(Royal Society of Chemistry, 2021)The preparation of chondroitin sulfate (CS) oligosaccharide mimetics, more easily synthesized than natural sequences, is ...
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Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus
(Wiley-Blackwell, 2021)Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually ...
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From cyclic amines and acetonitrile to amidine zinc(II) complexes
(Royal Society of Chemistry, 2020)A seemingly simple combination of [Zn(quin)2(H2O)] (quin− = quinaldinate) and a selected secondary cyclic amine, piperidine ...
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Exploring protein phosphorylation by combining computational approaches and biochemical methods
(Elsevier, 2020)Post-translational modifications of proteins expand their functional diversity, regulating the response of cells to a ...
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Post-Translational Modifications of Cytochrome c in Cell Life and Disease
(MDPI, 2020)Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including ...
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Differential effects of carbohydrates on arabidopsis pollen germination
(Oxford University Press, 2017)Pollen germination as a crucial process in plant development strongly depends on the accessibility of carbon as energy ...
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Influence of the reducing-end anomeric configuration of the Man9 epitope on DC-SIGN recognition
(Royal Society of Chemistry, 2020)High-mannose (Man9GlcNAc2) is the main carbohydrate unit present in viral envelope glycoproteins such as gp120 of HIV and ...