Por motivos de mantenimiento se ha deshabilitado el inicio de sesión temporalmente. Rogamos disculpen las molestias.
Instituto de Investigaciones Químicas (IIQ) – CIC Cartuja: Recent submissions
Now showing items 1-20 of 286
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Article
Electrophilic Hydrosilylation of Electron-Rich Alkenes Derived from Enamines
(John Wiley & Sons, 2024-04-18)The low-electron count, air-stable, platinum complexes [Pt(ItBu’)(ItBu)][BArF] (C1) (ItBu=1,3-di-tert-butylimidazol-2-ylidene), ...
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Article
Diborane Reductions of CO2 and CS2 Mediated by Dicopper μ-Boryl Complexes of a Robust Bis(phosphino)-1,8-naphthyridine Ligand
(American Chemical Society, 2024-05-03)A dinucleating 1,8-naphthyridine ligand featuring fluorene-9,9-diyl-linked phosphino side arms (PNNPFlu) was synthesized ...
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Article
Synthesis of a New β-Galactosidase Inhibitor Displaying Pharmacological Chaperone Properties for GM1 Gangliosidosis
(MDPI, 2022)GM1 gangliosidosis is a rare lysosomal disease caused by the deficiency of the enzyme β-galactosidase (β-Gal; GLB1; E.C. ...
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Article
GCase Enhancers: A Potential Therapeutic Option for Gaucher Disease and Other Neurological Disorders
(MDPI, 2022)Pharmaceutical chaperones (PCs) are small compounds able to bind and stabilize misfolded proteins, allowing them to recover ...
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Article
σ‑GeH and Germyl Cationic Pt(II) Complexes
(ACS, 2022)The low electron count Pt(II) complexes [Pt(NHC′)(NHC)]- [BArF] (where NHC is a N-heterocyclic carbene ligand and NHC′ ...
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Article
Mechanistic Investigations on Hydrogenation, Isomerization and Hydrosilylation Reactions Mediated by a Germyl-Rhodium System
(Wiley, 2022)We recently disclosed a dehydrogenative double C−H bond activation reaction in the unusual pincer-type rhodium-germyl ...
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Article
Catalytic Nitrous Oxide Reduction with H2 Mediated by Pincer Ir Complexes
(American Chemical Society, 2022)Reduction of nitrous oxide (N2O) with H2 to N2 and water is an attractive process for the decomposition of this greenhouse ...
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Article
Formic Acid as Renewable Reagent and Product in Biomass Upgrading
(Elsevier, 2023)The problems associated with the use of molecular hydrogen (transportation, storage and high cost) have pushed scientists ...
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Article
PCNA molecular recognition of different PIP motifs: Role of Tyr211 phosphorylation
(Elsevier, 2024-07)The coordination of enzymes and regulatory proteins for eukaryotic DNA replication and repair is largely achieved by ...
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Article
A splice-altering homozygous variant in COX18 causes severe sensory-motor neuropathy with oculofacial apraxia
(Elsevier B.V., 2024-10)Cytochrome-c oxidase (COX) is part of the mitochondrial complex IV (CIV). COX deficiency is usually associated with tRNA ...
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Article
Phosphorylation at the disordered N-end makes HuR accumulate and dimerize in the cytoplasm.
(Oxford University Press, 2024-07-05)Human antigen R (HuR) is an RNA binding protein mainly involved in maintaining the stability and controlling the translation ...
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Article
SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer
(Elsevier, 2024-03-26)The posttranslational modification of proteins critically influences many biological processes and is a key mechanism that ...
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Article
sp2-Iminosugar Azobenzene O-glycosides: Light-sensitive Glycosidase Inhibitors with Unprecedented Tunability and Switching Factors
(Elsevier, 2024)The conventional approach to developing light-sensitive glycosidase activity regulators, involving the combination of a ...
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Article
Speeding-up the Determination of Protein-Ligand Affinities by STD NMR: The Reduced Data Set STD NMR Approach (rd-STD NMR)
(American Chemical Society, 2024-01-02)STD NMR spectroscopy is a powerful ligand-observed NMR tool for screening and characterizing the interactions of small ...
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Article
Atroposelective Synthesis of 2-(Quinolin-8-yl)benzyl Alcohols by Biocatalytic Dynamic Kinetic Resolutions
(Wiley, 2023-12-22)A highly enantioselective biocatalytic dynamic kinetic resolution (DKR) of 2-(quinoline-8-yl) 3-methylbenzaldehydes and ...
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Article
Enzyme-Responsive Zr-Based Metal-Organic Frameworks for Controlled Drug Delivery: Taking Advantage of Clickable PEG-Phosphate Ligands
(American Chemical Society, 2023)We report for the first time the controlled drug release from a nanoscale Zr-based metal-organic framework (MOF), UiO-66, ...
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Article
Continuous flow synthesis of PCN-222 (MOF-545) with controlled size and morphology: a sustainable approach for efficient production
(Royal Society of Chemistry, 2023-11-21)Zirconium-based MOFs, such as PCN-222 (MOF-545), have gained attention due to their regular porosity, tuneable pore size, ...
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Article
On the athermal origin of flash sintering: Separating field-induced effects from Joule heating using a current ramp approach
(Pergamon-Elsevier Science LTD, 2024-03-16)Joule heating is generally acknowledged as the main driving force behind Flash Sintering. However, this view is challenged ...
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Article
Silver-free gold-catalyzed heterocyclizations through intermolecular H-bonding activation.
(AMER Chemical Soc, 2023-01-27)Modulable monosulfonyl squaramides have been shown to exert activation of gold(I) chloride complexes through H-bonding in ...
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Article
Dynamic Kinetic Resolution of Indole-Based Sulfenylated Heterobiaryls by Rhodium-Catalyzed Atroposelective Reductive Aldol Reaction
(Amer chemical SOC, 2023-08-30)A highly enantio- and diastereoselective dynamic kinetic resolution (DKR) of configurationally labile 3-aryl indole-2-carbaldehydes ...