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Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors
(Royal Society of Chemistry, 2015)
2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic potential for the treatment of various diseases, including several lysosomal storage disorders. ...
Article
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Insights in Cellular Uptake Mechanisms of pDNA-polycationic Amphiphilic Cyclodextrin Nanoparticles (CDplexes)
(Elsevier, 2010)
It is generally recognized that the major obstacle to efficient gene delivery is cellular internalization and endosomal escape of the DNA. Recently, we have developed a modular strategy for the preparation of well-defined ...
Article
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Debates: An Useful Tool to Promote Students Deeper Thinking in Stem Disciplines
(MDPI AG, 2018)
The utility of debates for the evaluation of a series of transversal competences related to critical thinking is highlighted. Our main target has been to depict a novel evaluation methodology via discussion through a ...
Patent. Invention
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Nuevos caramelos con elevado contenido en oligosacáridos prebióticos, procedimiento de preparación y utilización
(Organización Mundial de la Propiedad Intelectual (OMPI), 2009-12-30)
La presente invención se refiere a la transformación de azúcares alimentarios que contienen D-fructosa, en caramelos enriquecidos en oligosacáridos con actividad prebiótica mediante el uso de catalizadores ácidos sólidos, ...
PhD Thesis
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Reacciones de esteres 3-aminocrotonicos y compuestos beta-dicarbonilicos con nitroolefinas
(1978-12-11)
Se estudian dos tipos de procesos muy similares. Por una parte la intencion de nitroetilenos sustituidos: 2'-nitroestireno; 1-fenil-2-nitropropeno; 3 4 5 6 7-pentancetoxi-d. Galado 1-nitro-1-hepteno y 3 4 5 6-tetracetoxi ...
Article
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Application of Biobased Solvents in Asymmetric Catalysis
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
The necessity of more sustainable conditions that follow the twelve principles of Green Chemistry have pushed researchers to the development of novel reagents, catalysts and solvents for greener asymmetric methodologies. ...
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Effects of inulin and di-d-fructose dianhydride-enriched caramels on intestinal microbiota composition and performance of broiler chickens
(Elsevier, 2013)
In vitro and in vivo experiments were designed to evaluate the effectiveness of laboratory-made di-d-fructose dianhydride (DFA)-enriched caramels. The DFA-enriched caramels were obtained from d-fructose (FC), d-fructose ...
Article
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Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp2-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme
(Elsevier, 2016)
Due to their capacity to inhibit hexosaminidases, 2-acetamido-1,2-dideoxy-iminosugars have been widely studied as potential therapeutic agents for various diseases. An efficient stereoselective synthesis of 2-acetamido-1 ...
PhD Thesis
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Glicobióticos: desarrollo de caramelos con propiedades funcionales
(2017-07-17)
La investigación y la innovación en el terreno de los alimentos funcionales es actualmente un pilar esencial de la industria agroalimentaria, como lo demuestra la creciente demanda de estos productos por los consumidores, ...
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Olive-Oil-Derived Polyphenols Effectively Attenuate Inflammatory Responses of Human Keratinocytes by Interfering with the NF-κB Pathway
(Wiley, 2019)
Primary human keratinocytes are pretreated with HTy-Ac or HTy for 30 min and stimulated with IL-1β or Toll-like receptor 3 ligand (TLR3-l). Thymic stromal lymphopoietin (TSLP), measured by ELISA, is attenuated by both ...