Listar Química Orgánica por agencia financiadora "Ministerio de Ciencia, Innovación y Universidades (MICINN). España"
Mostrando ítems 1-16 de 16
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2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases
(Taylor & Francis, 2022)We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as ...
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A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Synthetic double-stranded small interfering RNAs (siRNAs) mimic interference RNAs (RNAi) and can bind target mRNAs with a ...
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Carbon Supported Gold Nanoparticles for the Catalytic Reduction of 4-Nitrophenol
(Frontiers Media, 2019)This work is a detailed study on how to optimize gold colloids preparation and their deposition to very different in nature ...
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Cyclodextrin-Based Functional Glyconanomaterials
(MDPI, 2020-12)Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical laboratories as “off-the-shelve” tools ...
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Enantio- and Diastereoselective Nucleophilic Addition of N-tert-Butylhydrazones to Isoquinolinium Ions through Anion-Binding Catalysis
(Wiley-Blackwell, 2021)A highly enantio- and diastereoselective thiourea-catalyzed dearomatization of isoquinolines employing N-tert-butylhydrazones ...
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NleB/SseK-catalyzed arginine-glycosylation and enteropathogen virulence are finely tuned by a single variable position contiguous to the catalytic machinery
(Royal Society of Chemistry, 2021)NleB/SseK effectors are arginine-GlcNAc-transferases expressed by enteric bacterial pathogens that modify host cell proteins ...
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Non-Ionic Osmotic Stress Induces the Biosynthesis of Nodulation Factors and Affects Other Symbiotic Traits in Sinorhizobium fredii HH103
(MDPI, 2023)Simple Summary: Rhizobia are soil proteobacteria able to establish nitrogen-fixing symbiosis with host legumes. This ...
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Scope and Limitations of Current Antibiotic Therapies against Helicobacter pylori: Reviewing Amoxicillin Gastroretentive Formulations
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Even though general improvement of quality of life has happened around the globe, statistics show that gastric cancer is ...
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sp2-Iminosugar Azobenzene O-glycosides: Light-sensitive Glycosidase Inhibitors with Unprecedented Tunability and Switching Factors
(Elsevier, 2024)The conventional approach to developing light-sensitive glycosidase activity regulators, involving the combination of a ...
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Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis
(American Chemical Society, 2020)The first examples of iminosugar-type 2-deoxy(thio)glycoside mimetics are reported. The key step is the activation of a ...
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Synthesis, conformational analysis and: In vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment
(Royal Society of Chemistry, 2020)The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides ...
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Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors
(Elsevier, 2019-11-01)Concerned by the devastating effects of Alzheimer's disease, and the lack of effective drugs, we have carried out the ...
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Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity
(Royal Society of Chemistry, 2024-03-05)A novel family of precision-engineered gene vectors with well-defined structures built on trehalose and trehalose-based ...
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Trifaceted Mickey Mouse Amphiphiles for Programmable Self-Assembly, DNA Complexation and Organ-Selective Gene Delivery
(Wiley, 2021)Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose-based trifaceted macrocyclic ...
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Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors
(Taylor & Francis Open Access, 2021)We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. ...
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Unravelling the Inflammatory Processes in the Early Stages of Diabetic Nephropathy and the Potential Effect of (Ss)-DS-ONJ
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Inflammatory processes play a central role in the pathogenesis of diabetic nephropathy (DN) in the early stages of the ...