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Browsing Artículos (Microbiología) by Author "Pascual Hernández, Álvaro"
Now showing items 21-40 of 107
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Article
Detection of low-level fosfomycin-resistant variants by decreasing glucose-6-phosphate concentration in fosfomycin susceptibility determination
Martín Gutiérrez, Guillermo; Docobo Pérez, Fernando; Rodríguez Martínez, José Manuel; Pascual Hernández, Álvaro; Blázquez, Jesús; Rodríguez Beltrán, Jerónimo (Multidisciplinary Digital Publishing Institute (MDPI), 2020)Mutations that confer low-level fosfomycin resistance (LLFR) but not clinical resistance in Escherichia coli are increasingly ...
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Article
Detection of plasmid-mediated quinolone resistance genes in clinical isolates of Enterobacter spp. in Spain
Calvo, Jorge; Cano, María Elicier; Rodríguez Martínez, José Manuel; Agüero, J.; Pascual Hernández, Álvaro; Velasco Ramírez, María del Carmen; Francia, M. V.; Martínez Martínez, Luis (American Society for Microbiology, 2009)We have studied by PCR and DNA sequencing the presence of the qnrA, qnrB, qnrS, aac(6′)-Ib-cr, qepA, intI1, and ISCR1 genes ...
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Article
Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes
Hernández Allés, Santiago; Benedí, Vicente J.; Martínez Martínez, Luis; Pascual Hernández, Álvaro; Aguilar, Alicia; Tomás, Juan M.; Albertí, Sebastián (American Society for Microbiology, 1999-01-01)We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) ...
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Article
Disbalancing Envelope Stress Responses as a Strategy for Sensitization of Escherichia coli to Antimicrobial Agents
Recacha Villamor, Esther; Fox, Valeria; Díaz Díaz, Sara; García Duque, Ana; Docobo Pérez, Fernando; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel (Frontiers Media, 2021)Disbalancing envelope stress responses was investigated as a strategy for sensitization of Escherichia coli to antimicrobial ...
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Article
Do specific antimicrobial stewardship interventions have an impact on carbapenem resistance in Gramnegative bacilli? A multicentre quasi-experimental ecological study: time-trend analysis and characterization of carbapenemases
Álvarez-Marín, Rocío; López Cerero, Lorena; Palop-Borras, Begoña; Rojo-Martín, María Dolores; Ruiz-Sancho, Andrés; Herrero-Rodríguez, Carmen; García, María Victoria; Lazo-Torres, Ana María; López, Inmaculada; Martín-Hita, Lina; Nuño-Álvarez, Enrique; Sánchez-Yebra, Waldo; Galán-Sánchez, Fátima; Reguera-Iglesias, José María; Lepe Jiménez, José Antonio; Peñalva, Germán; Pascual Hernández, Álvaro; Cisneros, José Miguel (Oxford University Press, 2021)Background: Carbapenem-resistant Gram-negative bacilli (CR-GNB) are among the most threatening microorganisms worldwide ...
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Article
Duration of Colonization by Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae in Healthy Newborns and Associated Risk Factors: a Prospective Cohort Study
Rodríguez Revuelta, María; López Cerero, Lorena; Serrano, Lara; Luna Lagares, Salud; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Oxford University Press, 2018)Duration of colonization by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) and factors associated ...
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Article
Effect of Glycerol on Fosfomycin Activity against Escherichia coli
Ortiz Padilla, Miriam; Portillo Calderón, Inés María; Velázquez Escudero, Ana; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel; Docobo Pérez, Fernando (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Fosfomycin is an antimicrobial that inhibits the biosynthesis of peptidoglycan by entering the bacteria through two channels ...
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Article
Effect of Statin Therapy in the Outcome of Bloodstream Infections Due to Staphylococcus aureus: A Prospective Cohort Study
López Cortés, Luis Eduardo; Gálvez-Acebal, Juan; Toro López, María Dolores del; Velasco Ramírez, María del Carmen; Cueto López, Marina de; Caballero, Francisco J.; Muniain Ezcurra, Miguel Angel; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Public Library of Science (PLoS), 2013)Introduction: Statins have pleiotropic effects that could influence the prevention and outcome of some infectious ...
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Article
Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections A Randomized Clinical Trial
Sojo Dorado, Jesús; López Hernández, Inmaculada; Rosso Fernández, Clara; Morales, Isabel; Palacios-Baena, Zaira R.; Hernández Torres, Alicia; Lobo Acosta, María Ángeles; Merino Bohórquez, Vicente; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús; Retamar Gentil, Pilar (Jama Nerwork Open, 2022)Importance The consumption of broad-spectrum drugs has increased as a consequence of the spread of multidrug-resistant ...
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Article
Effectiveness of fosfomycin trometamol as oral step-down therapy for bacteraemic urinary tract infections due to MDR Escherichia coli: a post hoc analysis of the FOREST randomized trial
Sojo-Dorado, Jesus; Lopez-Hernandez, Inmaculada; Hernandez-Torres, Alicia; Retamar Gentil, Pilar; Merino de Lucas, Esperanza; Escola-Verge, Laura; Docobo Pérez, Fernando; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Oxford Academic, 2023)Background Fosfomycin is a potentially attractive option as step-down therapy for bacteraemic urinary tract infections ...
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Article
Efficacy of cefepime and imipenem in experimental murine pneumonia caused by porin-deficient Klebsiella pneumoniae producing CMY-2 β-lactamase
Pichardo, Cristina; Rodríguez Martínez, José Manuel; Pachón Ibáñez, María Eugenia; Conejo Gonzalo, Mª Carmen; Martínez Martínez, Luis; Pachón Díaz, Jerónimo; Pascual Hernández, Álvaro (American Society for Microbiology, 2005-08-01)Previous studies have shown decreased in vitro activity of zwitterionic cephalosporins and carbapenems against porin-deficient ...
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Article
Efficacy of Colistin and Its Combination With Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae.
Pachón Ibáñez, María Eugenia; Labrador Herrera, Gema; Cebrero Cangueiro, Tania; Díaz, Caridad; Pascual Hernández, Álvaro; Conejo Gonzalo, Mª Carmen (Frontiers Media, 2018)Despite the relevance of carbapenemase-producing Klebsiella pneumoniae (CP-Kp) infections there are a scarce number of ...
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Article
Efficacy of Fosfomycin and Its Combination With Aminoglycosides in an Experimental Sepsis Model by Carbapenemase-Producing Klebsiella pneumoniae Clinical Strains
Cebrero Cangueiro, Tania; Labrador Herrera, Gema; Pascual Hernández, Álvaro; Díaz, Caridad; Rodríguez-Baño, Jesús; Pachón Díaz, Jerónimo; Palacio, José P. del; Pachón Ibáñez, María Eugenia; Conejo Gonzalo, Mª Carmen (Frontiers Media, 2021)Carbapenemase-producing Klebsiella pneumoniae infections are an increasing global threat with scarce and uncertain treatment ...
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Article
Efficacy of β-lactam/β-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients
Pierrotti, L. C; Pérez-Nadales, E.; Fernández-Ruiz, M.; Gutiérrez Gutiérrez, Belén; Tan, B. H.; Carratalà, J.; Cordero Matia, María Elisa; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús; Aguado, J. M. (Willey-Blackwell, 2021)Background Whether active therapy with β-lactam/β-lactamase inhibitors (BLBLI) is as affective as carbapenems for ...
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Article
Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains
Martínez Martínez, Luis; García Luque, Isabel; Ballesta Mudarra, Sofía; Benedí, Vicente J.; Hernández Allés, Santiago; Pascual Hernández, Álvaro (American Society for Microbiology, 1998-07-01)The intracellular accumulation of norfloxacin and perloxacin in Klebsiella pneumoniae was evaluated. The roles of ...
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Article
Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum β-lactamase production
Martínez Martínez, Luis; Pascual Hernández, Álvaro; Conejo Gonzalo, Mª Carmen; García Luque, Isabel; Joyanes, Providencia; Doménech Sánchez, Antonio; Benedí, Vicente J. (American Society for Microbiology, 2002-12-01)The relationships between porin deficiency, active efflux of fluoroquinolones, and extended-spectrum β-lactamase (ESBL) ...
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Article
Enhanced antibacterial activity of repurposed mitomycin C and imipenem in combination with the lytic phage vB_KpnMVAC13 against clinical isolates of klebsiella pneumoniae
Pacios, Olga; Fernández-García, Laura; Bleriot, Inés; Blasco, Lucía; González-Bardanca, Mónica; Pascual Hernández, Álvaro; Tomasa, María (American Society Microbiology, 2021)Klebsiella pneumoniae is an opportunistic Gram-negative pathogen that employs different strategies (resistance and ...
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Article
Epidemiologic and Clinical Impact of Acinetobacter baumannii Colonization and Infection: A Reappraisal
Villar, Macarena; Cano, María Elicier; Gato, Eva; Garnacho Montero, José; Cisneros, José Miguel; Ruiz de Alegría, C.; Pascual Hernández, Álvaro; Rodríguez-Baño, Jesús (Lippincott Williams & Wilkins, 2014)Acinetobacter baumannii is one of the most important antibiotic-resistant nosocomial bacteria. We investigated changes in ...
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Article
Epidemiological and Clinical Complexity of Amoxicillin-Clavulanate- Resistant Escherichia coli
Rodríguez-Baño, Jesús; Oteo, Jesús; Ortega, Adriana; Villar, Macarena; Conejo Gonzalo, Mª Carmen; Bou, Germán; Aranzamendi-Zaldumbide, Maitane; Cercenado, Emilia; Gurguí, Mercè; Martínez-Martínez, Luis; Merino, María; Rivera, Alba; Oliver, Antonio; Weber, Irene; Pascual Hernández, Álvaro; Bartolomé, Rosa M.; Gónzalez López, Juan José; Campos, José (American Society for Microbiology, 2013-07)Two hundred twelve patients with colonization/infection due to amoxicillin-clavulanate (AMC)-resistant Escherichia coli ...
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Article
Epidemiology and Clinical Features of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Nonhospitalized Patients
Rodríguez-Baño, Jesús; Dolores Navarro, María; Romero, Luisa; Martínez-Martínez, Luis; Muniain Ezcurra, Miguel Angel; Perea J., Evelio; Pérez Cano, Ramón; Pascual Hernández, Álvaro (American Society for Microbiology, 2004-03)Infections due to extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (ESBLEC) in nonhospitalize patients ...