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Mostrando ítems 281-290 de 460
Artículo
The Emerging Role of RNA Modifications in DNA Double-Strand Break Repair
(Frontiers Media S.A., 2021)
The correct repair of DNA double-strand breaks is essential for maintaining the stability of the genome, thus ensuring the survival and fitness of any living organism. Indeed, the repair of these lesions is a complicated ...
Artículo
Quantitative analysis of protein-RNA interactions in fission yeast
(Elsevier, 2022)
Characterizing the interactions between RNAs and proteins in vivo is key to better understand how organisms regulate gene expression. Here, we describe a robust and quantitative protocol to measure specific RNA-protein ...
Artículo
STM2209-STM2208 (opvAB): A Phase Variation Locus of Salmonella enterica Involved in Control of O-Antigen Chain Length
(Public Library of Science, 2012)
STM2209 and STM2208 are contiguous loci annotated as putative protein-coding genes in the chromosome of Salmonella enterica. Lack of homologs in related Enterobacteria and low G+C content suggest that S. enterica may have ...
Artículo
Therapeutic Opportunities of Disrupting Genome Integrity inAdult Diffuse Glioma
(MDPI, 2022)
Adult diffuse glioma, particularly glioblastoma (GBM), is a devastating tumor of the central nervous system. The existential threat of this disease requires on-going treatment to counteract tumor progression. The present ...
Artículo
Artículo
Specificities and Redundancies in the NEL Family of Bacterial E3 Ubiquitin Ligases of Salmonella Enterica Serovar Typhimurium
(Frontiers Media, 2024)
Salmonella enterica serovar Typhimurium expresses two type III secretion systems, T3SS1 and T3SS2, which are encoded in Salmonella pathogenicity island 1 (SPI1) and SPI2, respectively. These are essential virulent factors ...
Artículo
New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation
(American Society for Microbiology, 2011)
Formation of a ribonucleoprotein particle (mRNP) competent for export requires the coupling of transcription with mRNA processing and RNA export. A key link between these processes is provided by the THO complex. To progress ...
Artículo
Gibberella fujikuroi mutants obtained with UV radiation and N-methyl-N'-nitro-N-nitrosoguanidine
(American Society for Microbiology, 1985)
N-methyi-N'-nitro-N-nitrosoguanidine (nitrosoguanidine) and to a lesser extent UV radiation are very mutagenic for Gibberella microconidia. The recommended nitrosoguanidine doses lead to much higher frequencies of mutants ...
Artículo
MRGBP, a member of the NuA4 complex, inhibits DNA double-strand break repair
(Wiley-Blackwell, 2021)
The repair of DNA breaks takes place in the context of chromatin and thus involves the activity of chromatin remodelers. The nucleosome acetyltransferase of H4 (NuA4) remodeler complex enables DNA break repair by relaxing ...