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Artículo
Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing
(Elsevier, 2021)
Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation. ...
Artículo
Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configuration
(Taylor & Francis, 2021)
mRNA homoeostasis is favoured by crosstalk between transcription and degradation machineries. Both the Ccr4-Not and the Xrn1-decaysome complexes have been described to influence transcription. While Ccr4-Not has been shown ...
Artículo
An Evolutionary Perspective of the Lipocalin Protein Family
(Frontiers Media, 2021)
The protein family of Lipocalins is ubiquitously present throughout the tree of life, with the exception of the phylum Archaea. Phylogenetic relationships of chordate Lipocalins have been proposed in the past based on ...
Artículo
Functional Characterization of Lysophosphatidylcholine: Acyl-CoA Acyltransferase Genes From Sunflower (Helianthus annuus L.)
(MDPI, 2020)
Lysophosphatidylcholine acyltransferase (LPCAT, EC 2.3.1.23) is an evolutionarily conserved key enzyme in the Lands cycle that catalyzes acylation of lysophosphatidylcholine (LPC) to produce phosphatidylcholine (PC), the ...
Artículo
C. elegans THSC/TREX-2 deficiency causes replication stress and genome instability
(The Company of Biologists, 2021)
Transcription is an essential process of DNA metabolism, yet it makes DNA more susceptible to DNA damage. THSC/TREX-2 is a conserved eukaryotic protein complex with a key role in mRNP biogenesis and maturation that prevents ...
Artículo
The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts
(Springer Nature, 2021)
ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF, ncBAF and PBAF) that share the BRG1 (also known as ...
Artículo
Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox
(Frontiers Media, 2020)
To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle ...
Artículo
Overexpression of budding yeast protein phosphatase Ppz1 impairs translation
(Elsevier, 2020)
The Ser/Thr protein phosphatase Ppz1 from Saccharomyces cerevisiae is the best characterized member of a family of enzymes only found in fungi. Ppz1 is regulated in vivo by two inhibitory subunits, Hal3 and Vhs3, which are ...
Artículo
Aging during C. elegans L1 quiescence
(Impact Journals LLC, 2020)
Artículo
Epigenetic biosensors for bacteriophage detection and phage receptor discrimination
(Society for Applied Microbiology, 2020)
Environmental monitoring of bacteria using phage-based biosensors has been widely developed for many different species. However, there are only a few available methods to detect specific bacteriophages in raw environmental ...