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Listar Artículos (Genética) por autor "Aguilera López, Andrés"
Mostrando ítems 1-20 de 81
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A genome-wide function of THSC/TREX-2 at active genes prevents transcription–replication collisions
Santos Pereira, José María; García Rubio, María Luisa; González Aguilera, Cristina; Luna Varo, Rosa María; Aguilera López, Andrés (Oxford University Press, 2014)The THSC/TREX-2 complex of Saccharomyces cerevisiae mediates the anchoring of transcribed genes to the nuclear pore, linking ...
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A new connection of mRNP biogenesis and export with transcription-coupled repair
Gaillard, Hélène; Wellinger, Ralf Erik; Aguilera López, Andrés (Oxford University Press, 2007)Although DNA repair is faster in the transcribed strand of active genes, little is known about the possible contribution ...
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A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin
Gómez González, Belén; Sessa, Gaetana; Carreira, Aura; Aguilera López, Andrés (Taylor & Francis, 2021)In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the ...
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A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination
Muñoz Galván, Sandra; García Rubio, María Luisa; Ortega Moreno, Pedro; Ruiz Pérez, José Francisco; Jimeno González, Sonia; Pardo, Benjamín; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2017)Replication forks stall at different DNA obstacles such as those originated by transcription. Fork stalling can lead to ...
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A novel class of Mrna-containing cytoplasmic granules are produced in response to UV-irradiation
Gaillard, Hélène; Aguilera López, Andrés (American Society for Cell Biology, 2008)Nucleic acids are substrates for different types of damage, but little is known about the fate of damaged RNAs. We addressed ...
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A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability
Cañas, Juan Carlos; García Rubio, María Luisa; García, Alicia; Antequera, Francisco; Gómez González, Belén; Aguilera López, Andrés (Genetics Society of America, 2022)The stability of the genome is occasionally challenged by the formation of DNA-RNA hybrids and R-loops, which can be ...
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A unified model for the molecular basis of Xeroderma pigmentosum-Cockayne Syndrome
Moriel Carretero, María; Herrera Moyano, Emilia; Aguilera López, Andrés (Taylor & Francis Open, 2015)Nucleotide Excision Repair (NER) is a pathway that removes lesions distorting the DNA helix. The molecular basis of the ...
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Actin nucleators safeguard replication forks by limiting nascent strand degradation
Nieminuszczy, J.; Martin, P. R.; Broderick, R.; Krwawicz, J.; Kanellou, A.; Mocanu, C.; Bousgouni, V.; Smith, C.; Aguilera López, Andrés; Niedzwiedz, Wojciech (Oxford University Press, 2023)Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability ...
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Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex
Gómez González, Belén; Aguilera López, Andrés (National Academy of Sciences, 2007)Activation-induced cytidine deaminase (AID) is a B cell enzyme essential for Ig somatic hypermutation and class switch ...
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ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
Jimeno González, Sonia; Prados Carvajal, Rosario; Fernández Ávila, María Jesús; Pinela Da Silva, Sonia Cristina; Silvestris, Domenico Alessandro; Endara Coll, Martin; Rodríguez Real, Guillermo; Domingo Prim, Judit; Mejías Navarro, Fernando; Romero Franco, Amador; Jimeno González, Silvia; Barroso, Sonia; Cesarini, Valeriana; Aguilera López, Andrés; Gallo, Angela; Visa, Neus; Huertas Sánchez, Pablo (Nature Publishing Group, 2021)The maintenance of genomic stability requires the coordination of multiple cellular tasks upon the appearance of DNA ...
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AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants
Ruiz Pérez, José Francisco; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2011)Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by ...
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An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination
Huertas Sánchez, Pablo; García Rubio, María Luisa; Wellinger, Ralf Erik; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Microbiology, 2006)THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. ...
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Artículo
BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair
Sessa, Gaetana; Gómez González, Belén; Silva, Sonia; Pérez Calero, Carmen; Beaurepere, Romane; Barroso Ceballos, Sonia Inés; Martineau, Sylvain; Martin, Charlotte A.; Ehlén, Åsa; Martínez, Juan S.; Lombard, Bérangére; Loew, Damarys; Vagner, Stéphan; Aguilera López, Andrés; Carreira, Aura (Wiley-Blackwell, 2021)The BRCA2 tumor suppressor is a DNA double-strand break (DSB) repair factor essential for maintaining genome integrity. ...
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Break-induced RNA–DNA hybrids (BIRDHs) in homologous recombination: friend or foe?
Gómez González, Belén; Aguilera López, Andrés (Wiley-Blackwell, 2023)Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome ...
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C. elegans THSC/TREX-2 deficiency causes replication stress and genome instability
Zheleva, Angelina; Pérez de Camino Cantos, Dolores; Fernández Fernández, Nuria; García Rubio, María Luisa; Askjaer, Peter; García Muse, Tatiana; Aguilera López, Andrés (The Company of Biologists, 2021)Transcription is an essential process of DNA metabolism, yet it makes DNA more susceptible to DNA damage. THSC/TREX-2 is ...
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Chromosomal translocations caused by either Pol32-dependent or Pol32-independent triparental break-induced replication
Ruiz Pérez, José Francisco; Gómez González, Belén; Aguilera López, Andrés (American Society for Microbiology, 2009)Double-strand breaks (DSBs) are harmful DNA lesions that can generate chromosomal rearrangements or chromosome losses if ...
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Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae
Gaillard, Hélène; Aguilera López, Andrés (Public Library of Science, 2014)During transcription, the nascent pre-mRNA undergoes a series of processing steps before being exported to the cytoplasm. ...
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Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases
Pardo, Benjamín; Aguilera López, Andrés (2012) -
Artículo
Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1
Moriel Carretero, María; Tous Rivera, Cristina; Aguilera López, Andrés (National Academy of Sciences, 2011)Yeast rad3-102, a mutant of the TFIIH complex involved in nucleotide excision repair (NER) and transcription, can perform ...
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DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
Marchena Cruz, Esther; Camino, Lola P.; Bhandari, Jay; Pinela Da Silva, Sonia Cristina; Marqueta Gracia, José Javier; Amdeen, Shahad A.; Guillén Mendoza, Cristina; García Rubio, María Luisa; Calderón Montaño, José Manuel; Xue, Xiaoyu; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2023)Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic ...