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Pervasive transcription enhances the accessibility of H-NS–silenced promoters and generates bistability in Salmonella virulence gene expression
(National Academy of Sciences, 2022)
In Escherichia coli and Salmonella, many genes silenced by the nucleoid structuring protein H-NS are activated upon inhibiting Rho-dependent transcription termination. This response is poorly understood and difficult to ...
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Association of snR190 snoRNA chaperone with early pre-60S particles is regulated by the RNA helicase Dbp7 in yeast
(Springer Nature, 2021)
Synthesis of eukaryotic ribosomes involves the assembly and maturation of precursor particles (pre-ribosomal particles) containing ribosomal RNA (rRNA) precursors, ribosomal proteins (RPs) and a plethora of assembly factors ...
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Social Chemical Communication Determines Recovery From L1 Arrest via DAF-16 Activation
(Frontiers Media, 2020)
In a population, chemical communication determines the response of animals to changing environmental conditions, what leads to an enhanced resistance against stressors. In response to starvation, the nematode Caenorhabditis ...
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The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential
(Taylor & Francis, 2021)
Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have recently reported that the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protects the genome by ...
Tesis Doctoral
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Regulatory roles of photoreceptors and non-coding RNA in Fusarium fujikuroi
(2021-05-20)
The genus Fusarium comprises hundreds of species of pathogenic and saprophytic fungi, usually characterized by a complex secondary metabolism. This includes the production of carotenoids, terpenoid pigments that give a ...
Tesis Doctoral
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RNA Helicases in 60S Ribosomal Subunit Biogenesis in Saccharomyces cerevisiae
(2020-11-10)
The ribosomes are the cellular organelles responsible for translating messenger RNA (mRNA) to proteins. In eukaryotic organisms, the ribosomes are composed by two subunits: the large subunit and the small subunit that come ...
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Cannabinoids induce cell death in leukaemic cells through Parthanatos and PARP-related metabolic disruptions
(Nature Publishing Group, 2024)
BACKGROUND: Several studies have described a potential anti-tumour effect of cannabinoids (CNB). CNB receptor 2 (CB2) is mostly present in hematopoietic stem cells (HSC). The present study evaluates the anti-leukaemic ...
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Salmonella Type III Secretion Effector SrfJ: A Glucosylceramidase Affecting the Lipidome and the Transcriptome of Mammalian Host Cells
(MDPI, 2023)
Type III secretion systems are found in many Gram-negative pathogens and symbionts of animals and plants. Salmonella enterica has two type III secretion systems associated with virulence, one involved in the invasion of ...
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Human prefoldin modulates co-transcriptional pre-mRNA splicing
(Oxford University Press, 2021)
Prefoldin is a heterohexameric complex conserved from archaea to humans that plays a cochaperone role during the co-translational folding of actin and tubulin monomers. Additional functions of prefoldin have been described, ...
Artículo
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The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes
(Oxford University Press, 2020)
The ribotoxin α-sarcin belongs to a family of ribonucleases that cleave the sarcin/ricin loop (SRL), a critical functional rRNA element within the large ribosomal subunit (60S), thereby abolishing translation. Whether ...