dc.creator | Montoya García, Tatiana | es |
dc.creator | Sánchez Hidalgo, Marina | es |
dc.creator | Castejón Martínez, María Luisa | es |
dc.creator | Rosillo Ramírez, María de los Ángeles | es |
dc.creator | González Benjumea, Alejandro | es |
dc.creator | Alarcón de la Lastra Romero, Catalina | es |
dc.date.accessioned | 2021-05-07T14:48:19Z | |
dc.date.available | 2021-05-07T14:48:19Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Montoya García, T., Sánchez Hidalgo, M., Castejón Martínez, M.L., Rosillo Ramírez, M.d.l.Á., González Benjumea, A. y Alarcón de la Lastra Romero, C. (2021). Dietary oleocanthal supplementation prevents inflammation and oxidative stress in collagen-induced arthritis in mice. Antioxidants, 10 (5), 650. | |
dc.identifier.issn | 2076-3921 | es |
dc.identifier.uri | https://hdl.handle.net/11441/108728 | |
dc.description.abstract | Oleocanthal (OLE), a characteristic and exclusive secoiridoid of Oleoaceae family, is mainly found in extra virgin olive oil (EVOO). Previous studies have reported its antioxidant, anti-inflammatory, antimicrobial, anticancer and neuroprotective effects. Since the pathogenesis of rheumatoid arthritis (RA) involves inflammatory and oxidative components, this study was designed to evaluate the preventive role of dietary OLE-supplemented effects in collagen-induced arthritis (CIA) murine model. Animals were fed with a preventive OLE-enriched dietary during 6 weeks previous to CIA induction and until the end of experiment time. At day 43 after first immunization, mice were sacrificed: blood was recollected and paws were histological and biochemically processed. Dietary OLE prevented bone, joint and cartilage rheumatic affections induced by collagen. Levels of circulatory matrix metalloproteinase (MMP)-3 and pro-inflammatory cytokines (IL-6, IL-1β, TNF-α, IL-17, IFN-γ) were significantly decreased in secoiridoid fed animals. Besides, dietary OLE was able to diminish COX-2, mPGES-1 and iNOS protein expressions and, also, PGE2 levels. The mechanisms underlying these protective effects could be related to Nrf-2/HO-1 axis activation and the inhibition of relevant signaling pathways including JAK-STAT, MAPKs and NF-κB, thus controlling the production of inflammatory and oxidative mediators. Overall, our results exhibit preliminary evidences about OLE, as a novel dietary tool for the prevention of autoimmune and inflammatory disorders, such as RA. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad AG-2017-89342-P | es |
dc.description.sponsorship | Junta de Andalucía CTS259, FQM134 | es |
dc.format | application/pdf | es |
dc.format.extent | 18 p. | es |
dc.language.iso | eng | es |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es |
dc.relation.ispartof | Antioxidants, 10 (5), 650. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Dietary oleocanthal supplementation prevents inflammation and oxidative stress in collagen-induced arthritis in mice | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.relation.projectID | AG-2017-89342-P | es |
dc.relation.projectID | CTS259 | es |
dc.relation.projectID | FQM134 | es |
dc.relation.publisherversion | https://doi.org/10.3390/antiox10050650 | es |
dc.identifier.doi | 10.3390/antiox10050650 | es |
dc.journaltitle | Antioxidants | es |
dc.publication.volumen | 10 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 650 | es |
dc.description.awardwinning | Premio Mensual Publicación Científica Destacada de la US. Facultad de Farmacia | |