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dc.creatorOrtiz Cerda, Tamara Andreaes
dc.creatorArgüelles Arias, Federicoes
dc.creatorIllanes Moreno, Matildees
dc.creatorGarcía Montes, Josefa Maríaes
dc.creatorTalero Barrientos, Elena Mªes
dc.creatorMacías García, Lauraes
dc.creatorAlcudia Cruz, Anaes
dc.creatorVázquez Román, María Victoriaes
dc.creatorMotilva Sánchez, Virginiaes
dc.creatorMiguel Rodríguez, Manuel dees
dc.date.accessioned2021-05-03T10:33:31Z
dc.date.available2021-05-03T10:33:31Z
dc.date.issued2020
dc.identifier.citationOrtiz Cerda, T.A., Argüelles Arias, F., Illanes Moreno, M., García Montes, J.M., Talero Barrientos, E.M., Macías García, L.,...,Miguel Rodríguez, M.d. (2020). Polyphenolic Maqui Extract as a Potential Nutraceutical to Treat TNBS-Induced Crohn' s Disease by the Regulation of Antioxidant and Anti-Inflammatory Pathways. Nutrient, 12 (6), 1752.
dc.identifier.issn2072-6643es
dc.identifier.urihttps://hdl.handle.net/11441/108347
dc.description.abstractNutraceuticals include a wide variety of bioactive compounds, such as polyphenols, which have been highlighted for their remarkable health benefits. Specially, maqui berries have shown great antioxidant activity and anti-inflammatory effects on some inflammatory diseases. The objectives of the present study were to explore the therapeutic effects of maqui berries on acute-phase inflammation in Crohn’s disease. Balb/c mice were exposed to 2,4,6-trinitrobenzene sulfonic acid (TNBS) via intracolonic administration. Polyphenolic maqui extract (Ach) was administered orally daily for 4 days after TNBS induction (Curative Group), and for 7 days prior to the TNBS induction until sacrifice (Preventive Group). Our results showed that both preventive and curative Ach administration inhibited body weight loss and colon shortening, and attenuated the macroscopic and microscopic damage signs, as well as significantly reducing transmural inflammation and boosting the recovery of the mucosal architecture and its muco-secretory function. Additionally, Ach promotes macrophage polarization to the M2 phenotype and was capable of down-regulating significantly the expression of inflammatory proteins COX-2 and iNOS, and at the same time it regulates the antioxidant Nrf-2/HO-1 pathway. In conclusion, this is the first study in which it is demonstrated that the properties of Ach as could be used as a preventive and curative treatment in Crohn’s disease.es
dc.description.sponsorshipJunta de Andalucía Sociedad Andaluza de Patología Digestiva 2016 (SAPD)’, Project 2018/00000802-CTS949es
dc.description.sponsorshipEspaña Ministerio de Educación y Ciencia project 2004/00001203es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofNutrient, 12 (6), 1752.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectmaquies
dc.subjectpolyphenolses
dc.subjectCrohn’s diseasees
dc.subjectinflammatory bowel diseasees
dc.subjectacute inflammationes
dc.subjectmacrophageses
dc.subjectantioxidantses
dc.subjectinflammatory proteinses
dc.titlePolyphenolic Maqui Extract as a Potential Nutraceutical to Treat TNBS-Induced Crohn' s Disease by the Regulation of Antioxidant and Anti-Inflammatory Pathwayses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicina
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química Orgánica y Farmacéutica
dc.relation.projectID2018/00000802-CTS949es
dc.relation.projectID2004/00001203es
dc.relation.publisherversionhttps://doi.org/10.3390/nu12061752es
dc.identifier.doi10.3390/nu12061752es
dc.journaltitleNutrientes
dc.publication.volumen12es
dc.publication.issue6es
dc.publication.endPage1752es
dc.contributor.funderMinisterio de Educación y Ciencia (MEC). España
dc.contributor.funderJunta de Andalucía
dc.description.awardwinningPremio Anual Publicación Científica Destacada de la US. Facultad de Medicina
dc.description.awardwinningPremio Mensual Publicación Científica Destacada de la US. Facultad de Medicina

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