dc.creator | Andrade-Talavera, Yuniesky | es |
dc.creator | Benito, Itziar | es |
dc.creator | Casañas, Juan José | es |
dc.creator | Rodríguez Moreno, Antonio | es |
dc.creator | Montesinos Gutiérrez, María Luz | es |
dc.date.accessioned | 2021-04-15T14:46:20Z | |
dc.date.available | 2021-04-15T14:46:20Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Andrade-Talavera, Y., Benito, I., Casañas, J.J., Rodríguez Moreno, A. y Montesinos, M.L. (2015). Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome. Neurobiology Of Disease, 82, 516-525. | |
dc.identifier.issn | 0969-9961 | es |
dc.identifier.uri | https://hdl.handle.net/11441/107152 | |
dc.description.abstract | Down's syndrome (DS) is the most prevalent genetic intellectual disability. Memory deficits significantly contribute to the cognitive dysfunction in DS. Previously, we discovered that mTOR-dependent local translation, a pivotal process for some forms of synaptic plasticity, is deregulated in a DS mouse model. Here, we report that these mice exhibit deficits in both synaptic plasticity (i.e., BDNF-long term potentiation) and the persistence of spatial long-term memory. Interestingly, these deficits were fully reversible using rapamycin, a Food and Drug Administration-approved specific mTOR inhibitor; therefore, rapamycin may be a novel pharmacotherapy to improve cognition in DS. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Neurobiology Of Disease, 82, 516-525. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Barnes maze | es |
dc.subject | BDNF-LTP | es |
dc.subject | ERK | es |
dc.subject | MTOR | es |
dc.subject | Pharmacotherapy | es |
dc.subject | Synaptic plasticity | es |
dc.subject | Trisomy 21 | es |
dc.subject | Ts1Cje | es |
dc.title | Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0969996115300528 | es |
dc.identifier.doi | 10.1016/j.nbd.2015.09.005 | es |
dc.journaltitle | Neurobiology Of Disease | es |
dc.publication.volumen | 82 | es |
dc.publication.initialPage | 516 | es |
dc.publication.endPage | 525 | es |