dc.creator | Cano Cano, Fátima | es |
dc.creator | Alcalde Estévez, Elena | es |
dc.creator | Gómez Jaramillo, Laura | es |
dc.creator | Iturregui, Marta | es |
dc.creator | Sánchez Fernández, Elena Matilde | es |
dc.creator | García Fernández, José Manuel | es |
dc.creator | Ortiz Mellet, Carmen | es |
dc.creator | Campos Caro, Antonio | es |
dc.creator | López Tinoco, Cristina | es |
dc.date.accessioned | 2021-04-08T07:38:15Z | |
dc.date.available | 2021-04-08T07:38:15Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Cano Cano, F., Alcalde Estévez, ., Gómez Jaramillo, L., Iturregui, M., Sánchez Fernández, E.M., García Fernández, J.M.,...,López Tinoco, C. (2021). Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy. Frontiers in immunology, 12, 632132. | |
dc.identifier.issn | 1664-3224 | es |
dc.identifier.uri | https://hdl.handle.net/11441/106812 | |
dc.description.abstract | Diabetic retinopathy (DR) is one of the most common complications of Diabetes Mellitus (DM) and is directly associated with inflammatory processes. Currently, neuro-inflammation is considered an early event in DR and proceeds via microglia polarization. A hallmark of DR is the presence of retinal reactive gliosis. Here we report the beneficial effect of (S S,1R)-1-docecylsulfiny-5N,6O-oxomethylidenenojirimycin ((Ss)-DS-ONJ), a member of the sp2-iminosugar glycolipid (sp2-IGL) family, by decreasing iNOS and inflammasome activation in Bv.2 microglial cells exposed to pro-inflammatory stimuli. Moreover, pretreatment with (Ss)-DS-ONJ increased Heme-oxygenase (HO)-1 as well as interleukin 10 (IL10) expression in LPS-stimulated microglial cells, thereby promoting M2 (anti-inflammatory) response by the induction of Arginase-1. The results strongly suggest that this is the likely molecular mechanism involved in the anti-inflammatory effects of (S S)-DS-ONJ in microglia. (S S)-DS-ONJ further reduced gliosis in retinal explants from type 1 diabetic BB rats, which is consistent with the enhanced M2 response. In conclusion, targeting microglia polarization dynamics in M2 status by compounds with anti-inflammatory activities offers promising therapeutic interventions at early stages of DR. | es |
dc.description.sponsorship | España Instituto de Salud Carlos III (PI18/01287) | es |
dc.description.sponsorship | España Consejerıa de Salud de la Junta de Andalucía (PI- 0123-2018) | es |
dc.format | application/pdf | es |
dc.format.extent | 14 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers | es |
dc.relation.ispartof | Frontiers in immunology, 12, 632132. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | sp2-iminosugar glycolipids | es |
dc.subject | diabetic retinopathy | es |
dc.subject | microglia | es |
dc.subject | immunomodulation | es |
dc.subject | M2 response | es |
dc.title | Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.relation.projectID | (PI18/01287) | es |
dc.relation.projectID | (PI- 0123-2018) | es |
dc.relation.publisherversion | http://dx.doi.org/10.3389/fimmu.2021.632132 | es |
dc.identifier.doi | 10.3389/fimmu.2021.632132 | es |
dc.journaltitle | Frontiers in immunology | es |
dc.publication.volumen | 12 | es |
dc.publication.endPage | 632132 | es |