dc.creator | Rivero Barbarroja, Gonzalo | es |
dc.creator | Benito Hernández, Juan Manuel | es |
dc.creator | Ortiz Mellet, Carmen | es |
dc.creator | García Fernández, José Manuel | es |
dc.date.accessioned | 2021-03-03T12:27:18Z | |
dc.date.available | 2021-03-03T12:27:18Z | |
dc.date.issued | 2020-12 | |
dc.identifier.citation | Rivero Barbarroja, G., Benito Hernández, J.M., Ortiz Mellet, C. y García Fernández, J.M. (2020). Cyclodextrin-Based Functional Glyconanomaterials. Nanomaterials, 10 (12), 2517. | |
dc.identifier.issn | 2079-4991 | es |
dc.identifier.uri | https://hdl.handle.net/11441/105601 | |
dc.description.abstract | Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical
laboratories as “off-the-shelve” tools to manipulate the pharmacokinetics of a broad range of
active principles, due to their unique combination of biocompatibility and inclusion abilities.
The development of precision chemical methods for their selective functionalization, in combination
with “click” multiconjugation procedures, have further leveraged the nanoscaffold nature of these
oligosaccharides, creating a direct link between the glyco and the nano worlds. CDs have greatly
contributed to understand and exploit the interactions between multivalent glycodisplays and
carbohydrate-binding proteins (lectins) and to improve the drug-loading and functional properties
of nanomaterials through host–guest strategies. The whole range of capabilities can be enabled
through self-assembly, template-assisted assembly or covalent connection of CD/glycan building
blocks. This review discusses the advancements made in this field during the last decade and the
amazing variety of functional glyconanomaterials empowered by the versatility of the CD component. | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades y la Agencia Estatal de Investigación de España-RTI2018-097609-B-C21 | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación de España-PID2019-105858RB-I00 | es |
dc.description.sponsorship | Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.format | application/pdf | es |
dc.format.extent | 34 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Nanomaterials, 10 (12), 2517. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | cyclodextrins | es |
dc.subject | drug delivery | es |
dc.subject | gene delivery | es |
dc.subject | glyconanomaterials | es |
dc.subject | glyconanoparticles | es |
dc.subject | glycopolymers | es |
dc.subject | glycotargeting | es |
dc.subject | multivalency | es |
dc.subject | self-assembly | es |
dc.subject | supramolecular nanomaterials | es |
dc.title | Cyclodextrin-Based Functional Glyconanomaterials | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.relation.projectID | RTI2018-097609-B-C21 | es |
dc.relation.projectID | PID2019-105858RB-I00 | es |
dc.relation.publisherversion | https://doi.org/10.3390/nano10122517 | es |
dc.identifier.doi | 10.3390/nano10122517 | es |
dc.journaltitle | Nanomaterials | es |
dc.publication.volumen | 10 | es |
dc.publication.issue | 12 | es |
dc.publication.initialPage | 2517 | es |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (MICINN). España | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |