dc.creator | Bisogno, Fabricio R. | es |
dc.creator | Fernández Fernández, Rosario Fátima | es |
dc.creator | Lassaletta Simón, José María | es |
dc.creator | Gonzalo Calvo, Gonzalo de | es |
dc.date.accessioned | 2021-02-12T13:30:33Z | |
dc.date.available | 2021-02-12T13:30:33Z | |
dc.date.issued | 2021-01 | |
dc.identifier.citation | Bisogno, F.R., Fernández Fernández, R., Lassaletta Simón, J.M. y Gonzalo Calvo, G.d. (2021). Room Temperature Ionic Liquids in Asymmetric Hetero-Ene Type Reactions: Improving Organocatalyst Performance at Lower Temperatures. Molecules, 26 (2), 355. | |
dc.identifier.issn | 1420-3049 | es |
dc.identifier.uri | https://hdl.handle.net/11441/104914 | |
dc.description.abstract | Abstract: Room temperature ionic liquids (RTILs) have been widely used as (co)solvents in several
catalytic processes modifying, in most of the cases, the catalyst activity and/or the selectivity for
the studied reactions. However, there are just a few examples of their use in hydrogen bonding
organocatalysis. In this paper, we show the positive effect of a set of imidazole-based ionic liquids
([bmim]BF4 and [hmim]PF6
) in the enantioselective addition of formaldehyde tert-butylhydrazone
to prochiral α-keto esters catalyzed by a sugar-based chiral thiourea. Reactions performed in the
presence of low percentages of RTILs led to an increase of the catalyst activity, thereby making
possible to work at lower temperatures. Thus, the chiral tert-butyl azomethyl tertiary alcohols could
be obtained with moderate to good conversions and higher enantioselectivities for most of the studied
substrates when using up to 30 vol% of [hmim]PF6 as a cosolvent in processes performed in toluene. | es |
dc.description.sponsorship | Ministerio de Economia, Industria y Competitividad del gobierno español-CTQ2016- 76908-C2-1-P y CTQ2016- 76908-C2-2-P | es |
dc.description.sponsorship | Fondos europeos FEDER y Junta de Andalucía- Beca P18-FR-3531 | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Molecules, 26 (2), 355. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | organocatalysis | es |
dc.subject | ionic liquids | es |
dc.subject | ene-type reactions | es |
dc.subject | tertiary alcohols | es |
dc.subject | solvent engineering | es |
dc.subject | asymmetric catalysis | es |
dc.title | Room Temperature Ionic Liquids in Asymmetric Hetero-Ene Type Reactions: Improving Organocatalyst Performance at Lower Temperatures | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica | es |
dc.relation.projectID | CTQ2016- 76908-C2-1-P | es |
dc.relation.projectID | CTQ2016- 76908-C2-2-P | es |
dc.relation.projectID | P18-FR-3531 | es |
dc.relation.publisherversion | https://doi.org/10.3390/molecules26020355 | es |
dc.identifier.doi | 10.3390/molecules26020355 | es |
dc.journaltitle | Molecules | es |
dc.publication.volumen | 26 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 355 | es |
dc.contributor.funder | Ministerio de Economia, Industria y Competitividad (MINECO). España | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Junta de Andalucía | es |