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dc.creatorVázquez Madrigal, Carloses
dc.creatorLópez, Soledades
dc.creatorGrao Cruces, Elenaes
dc.creatorMillán-Linares, María del Carmenes
dc.creatorRodriguez-Martin, Noelia M.es
dc.creatorMartín Rubio, María Estheres
dc.creatorAlba, Gonzaloes
dc.creatorSanta-María Pérez, Consueloes
dc.creatorBermúdez Pulgarín, Beatrizes
dc.creatorMontserrat de la Paz, Sergioes
dc.date.accessioned2020-12-04T10:44:48Z
dc.date.available2020-12-04T10:44:48Z
dc.date.issued2020
dc.identifier.citationVázquez Madrigal, C., López, S., Grao Cruces, E., Millán-Linares, M.d.C., Rodriguez-Martin, N.M., Martín Rubio, M.E.,...,Montserrat de la Paz, S. (2020). Dietary fatty acids in postprandial triglyceride-rich lipoproteins modulate human monocyte-derived dendritic cell maturation and activation. Nutrients, 12 (10), 1-13.
dc.identifier.issn2072-6643 (electrónico)es
dc.identifier.urihttps://hdl.handle.net/11441/103036
dc.description.abstractDietary fatty acids have been demonstrated to modulate systemic inflammation and induce the postprandial inflammatory response of circulating immune cells. We hypothesized that postprandial triglyceride-rich lipoproteins (TRLs) may have acute effects on immunometabolic homeostasis by modulating dendritic cells (DCs), sentinels of the immunity that link innate and adaptive immune systems. In healthy volunteers, saturated fatty acid (SFA)-enriched meal raised serum levels of granulocyte/macrophage colony-stimulating factor GM-CSF (SFAs > monounsaturated fatty acids (MUFAs) = polyunsaturated fatty acids (PUFAs)) in the postprandial period. Autologous TRL-SFAs upregulated the gene expression of DC maturation (CD123 and CCR7) and DC pro-inflammatory activation (CD80 and CD86) genes while downregulating tolerogenic genes (PD-L1 and PD-L2) in human monocyte-derived DCs (moDCs). These effects were reversed with oleic acid-enriched TRLs. Moreover, postprandial SFAs raised IL-12p70 levels, while TRL-MUFAs and TRL-PUFAs increased IL-10 levels in serum of healthy volunteers and in the medium of TRL-treated moDCs. In conclusion, postprandial TRLs are metabolic entities with DC-related tolerogenic activity, and this function is linked to the type of dietary fat in the meal. This study shows that the intake of meals enriched in MUFAs from olive oil, when compared with meals enriched in SFAs, prevents the postprandial production and priming of circulating pro-inflammatory DCs, and promotes tolerogenic response in healthy subjects. However, functional assays with moDCs generated in the presence of different fatty acids and T cells could increase the knowledge of postprandial TRLs’ effects on DC differentiation and function.es
dc.description.sponsorshipConsejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía US-1263458es
dc.description.sponsorshipFederes
dc.formatapplication/pdfes
dc.format.extent13 p.es
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofNutrients, 12 (10), 1-13.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFatty acidses
dc.subjectPostprandial statees
dc.subjectChylomicrones
dc.subjectOlive oiles
dc.subjectDendritic cellses
dc.subjectMyeloid lineagees
dc.subjectTriglyceride-rich lipoproteines
dc.titleDietary fatty acids in postprandial triglyceride-rich lipoproteins modulate human monocyte-derived dendritic cell maturation and activationes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Biología Celulares
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica y Biología Moleculares
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunologíaes
dc.relation.projectIDUS-1263458es
dc.relation.publisherversionhttps://doi.org/10.3390/nu12103139es
dc.identifier.doi10.3390/nu12103139es
dc.journaltitleNutrientses
dc.publication.volumen12es
dc.publication.issue10es
dc.publication.initialPage1es
dc.publication.endPage13es
dc.contributor.funderJunta de Andalucíaes
dc.contributor.funderEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)es

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