dc.creator | Vázquez Madrigal, Carlos | es |
dc.creator | López, Soledad | es |
dc.creator | Grao Cruces, Elena | es |
dc.creator | Millán-Linares, María del Carmen | es |
dc.creator | Rodriguez-Martin, Noelia M. | es |
dc.creator | Martín Rubio, María Esther | es |
dc.creator | Alba, Gonzalo | es |
dc.creator | Santa-María Pérez, Consuelo | es |
dc.creator | Bermúdez Pulgarín, Beatriz | es |
dc.creator | Montserrat de la Paz, Sergio | es |
dc.date.accessioned | 2020-12-04T10:44:48Z | |
dc.date.available | 2020-12-04T10:44:48Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Vázquez Madrigal, C., López, S., Grao Cruces, E., Millán-Linares, M.d.C., Rodriguez-Martin, N.M., Martín Rubio, M.E.,...,Montserrat de la Paz, S. (2020). Dietary fatty acids in postprandial triglyceride-rich lipoproteins modulate human monocyte-derived dendritic cell maturation and activation. Nutrients, 12 (10), 1-13. | |
dc.identifier.issn | 2072-6643 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/103036 | |
dc.description.abstract | Dietary fatty acids have been demonstrated to modulate systemic inflammation and induce
the postprandial inflammatory response of circulating immune cells. We hypothesized that postprandial
triglyceride-rich lipoproteins (TRLs) may have acute effects on immunometabolic homeostasis by
modulating dendritic cells (DCs), sentinels of the immunity that link innate and adaptive immune
systems. In healthy volunteers, saturated fatty acid (SFA)-enriched meal raised serum levels of
granulocyte/macrophage colony-stimulating factor GM-CSF (SFAs > monounsaturated fatty acids
(MUFAs) = polyunsaturated fatty acids (PUFAs)) in the postprandial period. Autologous TRL-SFAs
upregulated the gene expression of DC maturation (CD123 and CCR7) and DC pro-inflammatory
activation (CD80 and CD86) genes while downregulating tolerogenic genes (PD-L1 and PD-L2) in human
monocyte-derived DCs (moDCs). These effects were reversed with oleic acid-enriched TRLs. Moreover,
postprandial SFAs raised IL-12p70 levels, while TRL-MUFAs and TRL-PUFAs increased IL-10 levels in
serum of healthy volunteers and in the medium of TRL-treated moDCs. In conclusion, postprandial
TRLs are metabolic entities with DC-related tolerogenic activity, and this function is linked to the type of
dietary fat in the meal. This study shows that the intake of meals enriched in MUFAs from olive oil,
when compared with meals enriched in SFAs, prevents the postprandial production and priming of
circulating pro-inflammatory DCs, and promotes tolerogenic response in healthy subjects. However,
functional assays with moDCs generated in the presence of different fatty acids and T cells could increase
the knowledge of postprandial TRLs’ effects on DC differentiation and function. | es |
dc.description.sponsorship | Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía US-1263458 | es |
dc.description.sponsorship | Feder | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Nutrients, 12 (10), 1-13. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Fatty acids | es |
dc.subject | Postprandial state | es |
dc.subject | Chylomicron | es |
dc.subject | Olive oil | es |
dc.subject | Dendritic cells | es |
dc.subject | Myeloid lineage | es |
dc.subject | Triglyceride-rich lipoprotein | es |
dc.title | Dietary fatty acids in postprandial triglyceride-rich lipoproteins modulate human monocyte-derived dendritic cell maturation and activation | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.projectID | US-1263458 | es |
dc.relation.publisherversion | https://doi.org/10.3390/nu12103139 | es |
dc.identifier.doi | 10.3390/nu12103139 | es |
dc.journaltitle | Nutrients | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 10 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 13 | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.description.awardwinning | Premio Mensual Publicación Científica Destacada de la US. Facultad de Medicina | |