Artículo
A Concise Route for the Synthesis of Tetracyclic Meroterpenoids: (±)-Aureol Preparation and Mechanistic Interpretation
Autor/es | Rosales Martínez, Antonio
Enríquez Giraudo, Lourdes Jaraíz Maldonado, Martín Pozo-Morales, Laura Rodríguez-García, Ignacio Díaz Ojeda, Emilio |
Departamento | Universidad de Sevilla. Departamento de Ingeniería Química |
Fecha de publicación | 2020-08 |
Fecha de depósito | 2020-09-09 |
Publicado en |
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Resumen | A new concise general methodology for the synthesis of different tetracyclic meroterpenoids is reported: (±)-aureol (1), the key intermediate of this general route. The synthesis of (±)-aureol (1) was achieved in seven ... A new concise general methodology for the synthesis of different tetracyclic meroterpenoids is reported: (±)-aureol (1), the key intermediate of this general route. The synthesis of (±)-aureol (1) was achieved in seven steps (28% overall yield) from (±)-albicanol. The key steps of this route include a C–C bond-forming reaction between (±)-albicanal and a lithiated arene unit and a rearrangement involving 1,2-hydride and 1,2-methyl shifts promoted by BF3•Et2O as activator and water as initiator. |
Identificador del proyecto | Project 2020/00001014 |
Cita | Rosales Martínez, A., Enríquez Giraudo, L., Jaraíz Maldonado, M., Pozo-Morales, L., Rodríguez-García, I. y Díaz Ojeda, E. (2020). A Concise Route for the Synthesis of Tetracyclic Meroterpenoids: (±)-Aureol Preparation and Mechanistic Interpretation. Marine Drugs, 18 (9), 441-. |
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