dc.creator | Lopez, Jose J. | es |
dc.creator | Jardin, Isaac | es |
dc.creator | Sanchez-Collado, Jose | es |
dc.creator | Salido, Gines M. | es |
dc.creator | Smani Hajami, Tarik | es |
dc.creator | Rosado, Juan Antonio | es |
dc.date.accessioned | 2020-09-02T17:31:27Z | |
dc.date.available | 2020-09-02T17:31:27Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Lopez, J.J., Jardin, I., Sanchez-Collado, J., Salido, G.M., Smani Hajami, T. y Rosado, J.A. (2020). TRPC Channels in the SOCE Scenario. Cells, 9 (1) | |
dc.identifier.issn | 2073-4409 | es |
dc.identifier.uri | https://hdl.handle.net/11441/100659 | |
dc.description.abstract | Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels
that contribute to the modulation of a number of physiological functions in a variety of cell types.
Since the identification of TRP proteins in Drosophila, it is well known that these channels are activated
by stimuli that induce PIP2 hydrolysis. The canonical TRP (TRPC) channels have long been suggested
to be constituents of the store-operated Ca2+ (SOC) channels; however, none of the TRPC channels
generate Ca2+ currents that resemble ICRAC. STIM1 and Orai1 have been identified as the components
of the Ca2+ release-activated Ca2+ (CRAC) channels and there is a body of evidence supporting that
STIM1 is able to gate Orai1 and TRPC1 in order to mediate non-selective cation currents named ISOC.
STIM1 has been found to interact to and activate Orai1 and TRPC1 by different mechanisms and
the involvement of TRPC1 in store-operated Ca2+ entry requires both STIM1 and Orai1. In addition
to the participation of TRPC1 in the ISOC currents, TRPC1 and other TRPC proteins might play a
relevant role modulating Orai1 channel function. This review summarizes the functional role of
TRPC channels in the STIM1–Orai1 scenario. | es |
dc.description.sponsorship | Junta de Extremadura Consejería de Economía e Infraestructura-FEDER Grant IB16046 y GR18061 | es |
dc.description.sponsorship | Junta de Extremadura TA18011 y TA18054 | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades | es |
dc.format | application/pdf | es |
dc.format.extent | 13 | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Cells, 9 (1) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | TRPC1 | es |
dc.subject | STIM1 | es |
dc.subject | Orai1 | es |
dc.subject | Calcium influx | es |
dc.subject | Store-operated Ca2+ entry (SOCE) | es |
dc.title | TRPC Channels in the SOCE Scenario | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://doi.org/10.3390/cells9010126 | es |
dc.identifier.doi | 10.3390/cells9010126 | es |
dc.journaltitle | Cells | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 1 | es |
dc.identifier.sisius | 4824 | es |