Artículo
Hemp protein hydrolysates modulate inflammasome-related genes in microglial cells
Autor/es | Montserrat de la Paz, Sergio
Carrillo-Berdasco, Gabriela Rivero-Pino, Fernando Villanueva-Lazo, Álvaro Millán-Linares, María del Carmen |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Fecha de publicación | 2022-12-27 |
Fecha de depósito | 2023-06-13 |
Publicado en |
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Resumen | A prolonged inflammatory response can lead to the development of neurodegenerative
diseases such as Alzheimer’s disease. Enzymatic hydrolysis is a sustainable way to increase the
value of protein sources by obtaining ... A prolonged inflammatory response can lead to the development of neurodegenerative diseases such as Alzheimer’s disease. Enzymatic hydrolysis is a sustainable way to increase the value of protein sources by obtaining peptides that can exert bioactivity. Hemp (Cannabis sativa L.) protein hydrolysates have been proven to exert anti-inflammatory activity. In this study, two hemp protein hydrolysate (HPHs), obtained with Alcalase as sole catalyst, or with Alcalase followed by Flavourzyme, were evaluated as inflammatory mediators (TNFα, IL-1β, IL-6, and IL-10), microglial polarization markers (Ccr7, iNos, Arg1, and Ym1), and genes related to inflammasome activation (Nlrp3, Asc, Casp1, and Il18), employing the lipopolysaccharide (LPS)-induced neuroinflammation model in murine BV-2 microglial cells. A significant decrease of the expression of proinflammatory genes (e.g., Tnfα, Ccr7, inos, and Nlrp3, among others) and increase of the expression anti-inflammatory cytokines in microglial cells was observed after treatment with the test HPHs. This result in the cell model suggests a polarization toward an anti-inflammatory M2 phenotype. Our results show that the evaluated HPHs show potential neuroprotective activity in microglial cells via the inflammasome. |
Agencias financiadoras | Plan Andaluz de Investigación, Desarrollo e Innovación. España |
Identificador del proyecto | P20_00661 |
Cita | Montserrat de la Paz, S., Carrillo-Berdasco, G., Rivero-Pino, F., Villanueva-Lazo, Á. y Millán-Linares, M.d.C. (2022). Hemp protein hydrolysates modulate inflammasome-related genes in microglial cells. Biology, 12 (1), 49. https://doi.org/10.3390/biology12010049. |
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