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Listar por autor "Huertas Sánchez, Pablo"
Mostrando ítems 21-40 de 51
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Artículo
Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair
Huertas Sánchez, Pablo; Jackson, Stephen P. (American Society for Biochemistry and Molecular Biology, 2009)In G0 and G1, DNA double strand breaks are repaired by nonhomologous end joining, whereas in S and G2, they are also repaired ...
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Tesis Doctoral
Identificación de nuevas proteínas que interaccionan con CtIP: Implicación de PRMT5 y CCAR2 en la resección del ADN
López Saavedra, Ana (2017-06-06)DNA double-strand breaks (DSBs) represent the most cytotoxic DNA lesion that can arise from either endogenous and exogenous ...
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Artículo
Metallo-Liposomes of Ruthenium Used as Promising Vectors of Genetic Material
Lebrón Romero, José Antonio; Ostos Marcos, Francisco José; López López, Manuel; Moyá Morán, María Luisa; Sales, Carlos; García, Encarnación; García Calderón, Clara Beatriz; García Calderón, Margarita; Peña Gómez, Mª José; Valle Rosado, Iván; Romero Balestra, Fernando; Huertas Sánchez, Pablo; López-Cornejo, María del Pilar (MDPI, 2020)Gene therapy is a therapeutic process consisting of the transport of genetic material into cells. The design and preparation ...
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Tesis Doctoral
Molecular basis of Aicardi-Goutières syndrome
Moó Bajo, Andrea (2023-09-21)DNA is an essential molecule for the proper functioning of the cell that is constantly exposed to exogenous and endogenous ...
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Artículo
MRGBP, a member of the NuA4 complex, inhibits DNA double-strand break repair
Rivero Canalejo, Sabrina; Rodríguez Real, Guillermo; Marín, Inés; Huertas Sánchez, Pablo (Wiley-Blackwell, 2021)The repair of DNA breaks takes place in the context of chromatin and thus involves the activity of chromatin remodelers. ...
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Artículo
Multivalent Calixarene-Based Liposomes as Platforms for Gene and Drug Delivery
Lebrón Romero, José Antonio; López López, Manuel; García Calderón, Clara Beatriz; Valle Rosado, Iván; Romero Balestra, Fernando; Huertas Sánchez, Pablo; Rodik, Roman V; Kalchenko, Vitaly I.; Bernal Pérez, Eva; Moyá Morán, María Luisa; López-Cornejo, María del Pilar; Ostos Marcos, Francisco José (MDPI, 2021-08)The formation of calixarene-based liposomes was investigated, and the characterization of these nanostructures was carried ...
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Artículo
N7-methylguanosine methylation of tRNAs regulates survival to stress in cancer
García Vílchez, Raquel; Añazco Guenkova, Ana M.; López, Judith; Dietmann, Sabine; Tomé, Mercedes; Jimeno González, Sonia; Azkargorta, Mikel; Elortza, Félix; Bárcena, Laura; Huertas Sánchez, Pablo; Blanco, Sandra (Springer Nature, 2023)Tumour progression and therapy tolerance are highly regulated and complex processes largely dependent on the plasticity ...
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Artículo
Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice
Jimeno González, Sonia; Fernández Ávila, María Jesús; Cruz García, Andrés; Cepeda García, Cristina; Gómez Cabello, Daniel; Huertas Sánchez, Pablo (Oxford University Press, 2015)DNA double strand breaks are the most cytotoxic lesions that can occur on the DNA. They can be repaired by different ...
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Tesis Doctoral
New insights into CtIP protein: expression in breast cancer and regulation by sumoylation
Soria Bretones, Isabel (2017-09-22)Las roturas de doble cadena representan el tipo más nocivo entre todas las posibles lesiones que pueden ocurrir en el ADN, ...
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Artículo
New tools to study DNA double-strand break repair pathway choice
Gómez Cabello, Daniel; Jimeno González, Sonia; Fernández Ávila, María Jesús; Huertas Sánchez, Pablo (2013) -
Tesis Doctoral
Non-canonical DNA structures in Double Strand Break repair
Camarillo Daza, María Rosa (2023-05-22)DNA double-strand breaks (DSBs) pose a serious threat to genome stability, so their proper repair is crucial for cell ...
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Artículo
Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair
Prados Carvajal, Rosario; Huertas Sánchez, Pablo; Gavish Izakson, Michal; Bhavana Velpula, Bhagya; Elkon, Ran (Oxford University Press, 2018)The DNA damage response (DDR) is an extensive signaling network that is robustly mobilized by DNA double-strand breaks ...
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Tesis Doctoral
Papel del RNA en expresión genética y recombinación en Saccharomyces cerevisiae
Huertas Sánchez, Pablo (2004)La información necesaria para la supervivencia celular se encuentra codificada en el genoma. Cualquier proceso que conlleve ...
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Artículo
PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks
Alonso de la Vega, Ignacio; Paz Cabrera, María Cristina; Rother, Magdalena B; Wiegant, Wouter W; Checa Rodríguez, Cintia; Hernández Fernaud, Juan Ramón; Huertas Sánchez, Pablo; Freire, Raimundo; Attikum, Haico van; Smits, Veronique A J (Oxford University Press, 2020)Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the ...
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Artículo
Prognostic value of CtIP/RBBP8 expression in breast cancer
Soria Bretones, Isabel; Ruíz Borrego, Manuel; Japón Rodríguez, Miguel Ángel; Huertas Sánchez, Pablo (Wiley Open Access, 2013)CtIP/RBBP8 is a multifunctional protein involved in transcription, DNA replication, DNA repair by homologous recombination ...
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Tesis Doctoral
Regulación de la reparación de los cortes de doble cadena en el ADN: papel de la nedilación de proteínas
Fernández Ávila, María Jesús (2016-07-14)Las roturas de doble cadena del ADN son las lesiones más citotóxicas que pueden ocurrir en el ADN. Pueden ser reparadas ...
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Tesis Doctoral
Regulation of DNA end resection by cell stemness
Checa Rodríguez, Cintia (2020-01-20)The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) holds great potential for clinic ...
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Tesis Doctoral
Regulation of resection by chromatin associated proteins
Mejías Navarro, Fernando (2019-05-24)La molécula de ADN está permanentemente expuesta a múltiples fuentes de daño que ponen en peligro la integridad genómica. ...
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Artículo
Speed matters: How subtle changes in DNA end resection rate affect repair
Huertas Sánchez, Pablo; Cruz García, Andrés (Taylor & Francis, 2015)The contribution of BRCA1 (breast cancer 1) to the repair of broken DNA is well established, but its real role at the ...
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Artículo
Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox
Vítor, Alexandra C.; Huertas Sánchez, Pablo; Legube, Gaëlle; Almeida, Sérgio F. de (Frontiers Media, 2020)To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have ...