Perfil del autor: López López, Óscar
Datos institucionales
| Nombre | López López, Óscar |
| Departamento | Química Orgánica |
| Área de conocimiento | Química Orgánica |
| Categoría profesional | Profesor Titular de Universidad |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
22
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Nº visitas
2344
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Nº descargas
3571
| Publicaciones |
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Tesis Doctoral
 Nuevos tio- y selenoderivados de carbohidratos en enfermedades degenerativas: cáncer y Alzheimer
(2022-07-08)
En la presente Tesis Doctoral se han desarrollado nuevas familias de compuestos bioactivos frente a enfermedades complejas ... |
Tesis Doctoral
Nuevos sistemas de reconocimiento molecular basados en organocalcógenos. Agentes antiparasitarios y antiproliferativos
(2022-07-07)
La presente Tesis Doctoral, desarrollada en cotutela entre los grupos de investigación Síntesis y Modificación de Productos ... |
Artículo
 2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases
(Taylor & Francis, 2022-01-01)
We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as ... |
Artículo
Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment
(Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-01)
Being aware of the enormous biological potential of organoselenium and polyphenolic compounds, we have accomplished the ... |
Artículo
Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis
(Taylor & Francis, 2022-01-01)
Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the ... |
Artículo
Iridium-and Palladium-Based Catalysts in the Pharmaceutical Industry
(Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-01)
Transition metal catalysts play a vital role in a wide range of industrial organic processes. The large-scale production ... |
Artículo
Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations
(Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-01)
(1) Background: carbonic anhydrases (CAs) are attractive targets for the development of new anticancer therapies; in ... |
Artículo
A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans
(Royal Society of Chemistry, 2022-01-01)
A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) ... |
Artículo
Metal- and metalloid-based compounds to target and reverse cancer multidrug resistance
(Elsevier, 2021-01-01)
Drug resistance remains the major cause of cancer treatment failure especially at the late stage of the disease. However, ... |
Artículo
Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
(Taylor & Francis Open Access, 2021-01-01)
The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers ... |
Artículo
Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors
(Taylor & Francis Open Access, 2021-01-01)
We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. ... |
Tesis Doctoral
Síntesis y evaluación de nuevas moléculas multidiana en la prevención de enfermedades degenerativas
(2020-03-13)
En la presente Tesis Doctoral se ha llevado a cabo la síntesis y evaluación de nuevos compuestos orgánicos como fármacos ... |
Artículo
Masked Phenolic-Selenium Conjugates: Potent and Selective Antiproliferative Agents Overcoming P-gp Resistance
(MDPI, 2020-01-01)
Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number ... |
Artículo
1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors
(American Chemical Society, 2020-01-01)
The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide ... |
Artículo
Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease
(American Chemical Society, 2020-01-01)
Despite the rapidly increasing number of patients suffering from type 2 diabetes, Alzheimer's disease, and diabetes-induced ... |
Artículo
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells
(MDPI, 2019-01-01)
With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new ... |
Artículo
Debates: An Useful Tool to Promote Students Deeper Thinking in Stem Disciplines
(MDPI AG, 2018-01-01)
The utility of debates for the evaluation of a series of transversal competences related to critical thinking is highlighted. ... |
Artículo
Synthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrates
(Royal Society of Chemistry, 2017-01-01)
The Michael addition reactions of carbohydrate-derived nitroalkenes with ethyl thioglycolate and 2-mercaptobenzyl alcohol ... |
Artículo
A Straightforward Access to New Families of Lipophilic Polyphenols by Using Lipolytic Bacteria
(Public Library of Science, 2016-01-01)
The chemical synthesis of new lipophilic polyphenols with improved properties presents technical difficulties. Here we ... |
Tesis Doctoral
Síntesis de nuevos antioxidantes derivados del hidroxitirosol. Interacción con ciclodextrinas
(2014-02-26)
En la presente Tesis Doctoral se ha llevado a cabo la preparación de derivados funcionales del hidroxitirosol (HT), con ... |
Artículo
Alkoxyamine-cyanoborane adducts: Efficient cyanoborane transfer agents
(Royal Society of Chemistry, 2011-01-01)
We report the synthesis of the hitherto unknown zwitterionic alkoxyamino cyanoboranes by reduction of O-alkyloximes with ... |
Tesis Doctoral
Compuestos organoselénicos derivados de carbohidratos. Isoselenocianatos, selenoureas y selenoheterociclos
(2007-12-20)
En esta Tesis Doctoral se ha puesto a punto un procedimiento eficaz de conversión de tioureas derivadas de azúcar en las ... |