NombreLópez López, Óscar
DepartamentoQuímica Orgánica
Área de conocimientoQuímica Orgánica
Categoría profesionalProfesor Titular de Universidad
Correo electrónicoSolicitar
           
  • Nº publicaciones

    22

  • Nº visitas

    2344

  • Nº descargas

    3571


 

Tesis Doctoral
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Nuevos tio- y selenoderivados de carbohidratos en enfermedades degenerativas: cáncer y Alzheimer

López López, Óscar; Merino Montiel, Penélope; Velueta Viveros, Martha (2022-07-08)
En la presente Tesis Doctoral se han desarrollado nuevas familias de compuestos bioactivos frente a enfermedades complejas ...
Tesis Doctoral
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Nuevos sistemas de reconocimiento molecular basados en organocalcógenos. Agentes antiparasitarios y antiproliferativos

López López, Óscar; Merino Montiel, Penélope; Martínez Montiel, Mónica (2022-07-07)
La presente Tesis Doctoral, desarrollada en cotutela entre los grupos de investigación Síntesis y Modificación de Productos ...
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2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases

Fuentes Aguilar, Alma; Merino Montiel, Penélope; Montiel Smith, Sara; Meza Reyes, Socorro; Vega Báez, José Luis; Fernández-Bolaños Guzmán, José María; López López, Óscar (Taylor & Francis, 2022-01-01)
We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as ...
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Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment

Begines Aguilar, Paloma; Martos Delgado, Sergio; Lagunes, Irene; Maya Castilla, Inés; Padrón, José M.; López López, Óscar; Fernández-Bolaños Guzmán, José María (Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-01)
Being aware of the enormous biological potential of organoselenium and polyphenolic compounds, we have accomplished the ...
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Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis

Ibáñez Escribano, Alexandra; Fonseca Berzal, Cristina; Martínez Montiel, Mónica; Álvarez Márquez, Manuel; Gómez Núñez, María; Lacueva Arnedo, Manuel; Espinosa Buitrago, Teresa; Martín Pérez, Tania; Escario, José Antonio; Merino Montiel, Penélope; Montiel Smith, Sara; Gómez Barrio, Alicia; López López, Óscar; Fernández-Bolaños Guzmán, José María (Taylor & Francis, 2022-01-01)
Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the ...
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Iridium-and Palladium-Based Catalysts in the Pharmaceutical Industry

López López, Óscar; Padrón, José M. (Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-01)
Transition metal catalysts play a vital role in a wide range of industrial organic processes. The large-scale production ...
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Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations

Arrighi, Giulia; Puerta, Adrián; Petrini, Andrea; Hicke, Francisco J.; Nocentini, Alessio; Fernandes, Miguel X.; Padrón, José M.; Supuran, Claudiu T.; Fernández-Bolaños Guzmán, José María; López López, Óscar (Multidisciplinary Digital Publishing Institute (MDPI), 2022-01-01)
(1) Background: carbonic anhydrases (CAs) are attractive targets for the development of new anticancer therapies; in ...
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A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans

García García, Amalia; Rojas, Sara; Rivas García, Lorenzo; Navarro Hortal, María D.; Romero Márquez, José M.; Fernández-Bolaños Guzmán, José María; López López, Óscar; Rodríguez-Diéguez, Antonio (Royal Society of Chemistry, 2022-01-01)
A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) ...
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Metal- and metalloid-based compounds to target and reverse cancer multidrug resistance

Valente, Andreia; Podolski-Renić, Ana; Poetsch, Isabella; Filipović, Nenad; López López, Óscar; Turel, Iztok; Heffeter, Petra (Elsevier, 2021-01-01)
Drug resistance remains the major cause of cancer treatment failure especially at the late stage of the disease. However, ...
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Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase

Evangelista, Tereza Cristina Santos; López López, Óscar; Ferreira, Sabrina Baptista; Fernández-Bolaños Guzmán, José María; Sydnes, Magne O.; Lindbäck, Emil (Taylor & Francis Open Access, 2021-01-01)
The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers ...
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Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors

Ahuja Casarín, Ana I.; Merino Montiel, Penélope; Vega Báez, José Luis; Montiel Smith, Sara; Fernandes, Miguel X,; Lagunes, Irene; Maya Castilla, Inés; López López, Óscar; Fernández-Bolaños Guzmán, José María (Taylor & Francis Open Access, 2021-01-01)
We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. ...
Tesis Doctoral
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Síntesis y evaluación de nuevas moléculas multidiana en la prevención de enfermedades degenerativas

Fernández-Bolaños Guzmán, José María; Maya Castilla, Inés; López López, Óscar; Roldán Peña, Jesús Miguel (2020-03-13)
En la presente Tesis Doctoral se ha llevado a cabo la síntesis y evaluación de nuevos compuestos orgánicos como fármacos ...
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Masked Phenolic-Selenium Conjugates: Potent and Selective Antiproliferative Agents Overcoming P-gp Resistance

Begines Aguilar, Paloma; Sevilla Horrillo, Lucía; Puerta, Adrián; Puckett, Rebeca; Bayort, Samuel; Lagunes, Irene; Maya Castilla, Inés; Padrón, José M.; López López, Óscar; Fernández-Bolaños Guzmán, José María (MDPI, 2020-01-01)
Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number ...
Artículo
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1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors

Haarr, Marianne B.; López López, Óscar; Pejov, Ljupcho; Fernández-Bolaños Guzmán, José María; Lindbäck, Emil; Sydnes, Magne O. (American Chemical Society, 2020-01-01)
The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide ...
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Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease

De Matos, Ana M.; Blázquez Sánchez, M. Teresa; Bento Oliveira, Andreia; de Almeida, Rodrigo F.M.; Nunes, Rafael; Lopes, Pedro E.M.; Machuqueiro, Miguel; Cristóvão, Joana S.; López López, Óscar; Fernández-Bolaños Guzmán, José María; Amélia P. (American Chemical Society, 2020-01-01)
Despite the rapidly increasing number of patients suffering from type 2 diabetes, Alzheimer's disease, and diabetes-induced ...
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Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells

Matos, Ana M. de; Martins, Alice; Man,Teresa; Evans, David; Walter, Magnus; Oliveira, Maria Conceição; López López, Óscar; Fernández-Bolaños Guzmán, José María; Rauter, Amélia P. (MDPI, 2019-01-01)
With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new ...
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Debates: An Useful Tool to Promote Students Deeper Thinking in Stem Disciplines

Gil Álvarez, María Victoria; Doncel Luengo, Juan Antonio; López López, Óscar; Rodríguez Cáceres, María Isabel; Palomino Vasco, Mónica (MDPI AG, 2018-01-01)
The utility of debates for the evaluation of a series of transversal competences related to critical thinking is highlighted. ...
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Synthesis and Antiproliferative Activity of Sulfa-Michael Adducts and Thiochromenes Derived from Carbohydrates

Luque Agudo, V.; Albarran Velo, J.; Fernández-Bolaños Guzmán, José María; López López, Óscar; Light, M.E.; Padrón, J.M.; Lagunes, I.; Román, E.; Serrano, J.A.; Gil, M.V.  (Royal Society of Chemistry, 2017-01-01)
The Michael addition reactions of carbohydrate-derived nitroalkenes with ethyl thioglycolate and 2-mercaptobenzyl alcohol ...
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A Straightforward Access to New Families of Lipophilic Polyphenols by Using Lipolytic Bacteria

Sánchez Barrionuevo, Leyre; González Benjumea, Alejandro; Escobar Niño, Almudena; García Gutiérrez, María Teresa; López López, Óscar; Maya Castilla, Inés; Fernández-Bolaños Guzmán, José María; Cánovas López, David; Mellado Durán, María Encarnación (Public Library of Science, 2016-01-01)
The chemical synthesis of new lipophilic polyphenols with improved properties presents technical difficulties. Here we ...
Tesis Doctoral
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Síntesis de nuevos antioxidantes derivados del hidroxitirosol. Interacción con ciclodextrinas

Maya Castilla, Inés; Fernández-Bolaños Guzmán, José María; López López, Óscar; Marset Castro, Azucena (2014-02-26)
En la presente Tesis Doctoral se ha llevado a cabo la preparación de derivados funcionales del hidroxitirosol (HT), con ...
Artículo
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Alkoxyamine-cyanoborane adducts: Efficient cyanoborane transfer agents

Márquez, José M.; Martínez Castro, Elisa; Gabrielli, Serena; López López, Óscar; Maya Castilla, Inés; Angulo, Manuel; Álvarez, Eleuterio; Fernández-Bolaños Guzmán, José María (Royal Society of Chemistry, 2011-01-01)
We report the synthesis of the hitherto unknown zwitterionic alkoxyamino cyanoboranes by reduction of O-alkyloximes with ...
Tesis Doctoral
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Compuestos organoselénicos derivados de carbohidratos. Isoselenocianatos, selenoureas y selenoheterociclos

Fernández-Bolaños Guzmán, José María; Maya Castilla, Inés; López López, Óscar; Maza Pérez, Susana (2007-12-20)
En esta Tesis Doctoral se ha puesto a punto un procedimiento eficaz de conversión de tioureas derivadas de azúcar en las ...