Data

NameSousa Martín, Carolina
DepartmentMicrobiología y Parasitología
Knowledge areaMicrobiología
Professional categoryCatedrática de Universidad
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  Publications

 

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Food Safety and Cross-Contamination of Gluten-Free Products: A Narrative Review

Wieser, Herbert; Segura Montero, Verónica; Ruiz Carnicer, Ángela; Sousa Martín, Carolina; Comino Montilla, Isabel María (MDPI, 2021-07-01)
A gluten-free diet (GFD) is currently the only effective treatment for celiac disease (CD); an individual’s daily intake ...
PhD Thesis
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Nuevas estrategias para el control de la enfermedad celíaca: caracterización de los péptidos imunogénicos del gluten y validación clínica de un biomarcador para el seguimiento del paciente celíaco

Sousa Martín, Carolina; Comino Montilla, Isabel María; Moreno Amador, María de Lourdes; Ruiz Carnicer, Ángela (2021-03-19)
La enfermedad celiaca (EC) se define como una enteropatía inflamatoria crónica del intestino delgado causada por la ingesta ...
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Rapid, effective, and versatile extraction of gluten in food with application on different immunological methods

Segura Montero, Verónica; Díaz, Jacobo; Ruiz Carnicer, Ángela; Muñoz Suano, Alba; Carrillo Carrión, Carolina; Sousa Martín, Carolina; Cebolla, Ángel; Comino Montilla, Isabel María (Multidisciplinary Digital Publishing Institute (MDPI), 2021-01-01)
One of the main concerns in gluten analysis is to achieve efficient extraction of gluten proteins. Conventional ethanol-based ...
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Dynamics and Considerations in the Determination of the Excretion of Gluten Immunogenic Peptides in Urine: Individual Variability at Low Gluten Intake

Coto, Laura; Sousa Martín, Carolina; Cebolla, Ángel (Multidisciplinary Digital Publishing Institute (MDPI), 2021-01-01)
Background: A lifelong strict gluten-free diet is the only available treatment for celiac disease, but total exclusion of ...
PhD Thesis
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Desarrollo de una metodología de aplicación y lectura de parche cutáneo estandarizado para el diagnóstico y manejo de la alergia a las proteínas de la leche de vaca no IgE mediada

Comino Montilla, Isabel María; Sousa Martín, Carolina; Romero Rueda, María de Gracia (2019-07-19)
El presente trabajo de investigación surgió de la necesidad de la creación de un plan de cuidados protocolizado y estandarizado ...
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Celiac Immunogenic Potential of α-Gliadin Epitope Variants from Triticum and Aegilops Species

Ruiz Carnicer, Ángela; Comino Montilla, Isabel María; Segura Montero, Verónica; Ozuna Serafini, Carmen Victoria; Moreno Amador, María de Lourdes; López Casado, Miguel Ángel; Torres López, María Isabel; Barro Losada, Francisco; Sousa Martín, Carolina (MDPI, 2019-01-01)
The high global demand of wheat and its subsequent consumption arise from the physicochemical properties of bread dough ...
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Prospective longitudinal study: use of faecal gluten immunogenic peptides to monitor children diagnosed with coeliac disease during transition to a gluten‐free diet

Comino Montilla, Isabel María; Segura Montero, Verónica; Ortigosa, Luis; Espín Jaime, Beatriz; Castillejo, Gemma; Millán, Antonio; Rodríguez Herrera, Alfonso; Cebolla Ramírez, Ángel; Sousa Martín, Carolina (Wiley, 2019-01-01)
Background Treatment for coeliac disease is a lifelong strict gluten‐free diet. Although guidelines recommend regular ...
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Stimulatory Response of Celiac Disease Peripheral Blood Mononuclear Cells Induced by RNAi Wheat Lines Differing in Grain Protein Composition

Sánchez León, Susana; Giménez, María J.; Comino Montilla, Isabel María; Sousa Martín, Carolina; López Casado, Miguel Ángel; Torres, María Isabel; Barro, Francisco (MDPI, 2019-01-01)
Wheat gluten proteins are responsible for the bread-making properties of the dough but also for triggering important ...
Final Degree Project
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Tratamientoy monitorización de la enfermedad Celiaca

Comino Montilla, Isabel María; Sousa Martín, Carolina; Ciudad Gutiérrez, Pablo (2018-07-01)
La enfermedad celíaca (EC) es considerada una patología crónica y sistémica desencadenada por ...
Final Degree Project
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Papel de la microbiota intestinal en nuestro organismo: una relación de beneficio mutuo

Sousa Martín, Carolina; Comino Montilla, Isabel María; Heredia Barroso, Abel (2018-07-01)
L a microbiota intestinal la componen una amplia variedad de especies de bacterias, hongos virus, arqueas y ...
Final Degree Project
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Prevalencia mundial de la enfermedad celíaca

Comino Montilla, Isabel María; Sousa Martín, Carolina; Muñoz Tello, Paola (2018-02-01)
La enfermedad celíaca (EC) se define como una enteropatía inflamatoria crónica del intestino delgado mediada inmunológicamente ...
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Low-gluten, nontransgenic wheat engineered with CRISPR/Cas9

Sánchez León, Susana; Gil Humanes, Javier; Ozuna Serafini, Carmen Victoria; Giménez, María J.; Sousa Martín, Carolina; Voytas, Daniel F.; Barro, Francisco (Wiley Open Access, 2018-01-01)
Coeliac disease is an autoimmune disorder triggered in genetically predisposed individuals by the ingestion of gluten ...
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Gluten Immunogenic Peptides as Standard for the Evaluation of Potential Harmful Prolamin Content in Food and Human Specimen

Cebolla Ramírez, Ángel; Moreno Amador, María de Lourdes; Coto, Laura; Sousa Martín, Carolina (MDPI, 2018-01-01)
Gluten is a complex mixture of storage proteins in cereals like wheat, barley, and rye. Prolamins are the main components ...
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The Dietary Intervention of Transgenic Low-Gliadin Wheat Bread in Patients with Non-Celiac Gluten Sensitivity (NCGS) Showed No Differences with Gluten Free Diet (GFD) but Provides Better Gut Microbiota Profile

Haro, Carmen; Villatoro, Myriam; Vaquero, Luis; Pastor, Jorge; Giménez, María J.; Ozuna Serafini, Carmen Victoria; Sánchez León, Susana; García Molina, María Dolores; Segura Montero, Verónica; Comino Montilla, Isabel María; Sousa Martín, Carolina (MDPI, 2018-01-01)
The study evaluated the symptoms, acceptance, and digestibility of bread made from transgenic low-gliadin wheat, in ...
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Biomarkers to monitor gluten-free diet compliance in celiac patients

Moreno Amador, María de Lourdes; Rodríguez Herrera, Alfonso; Sousa Martín, Carolina; Comino Montilla, Isabel María (MDPI, 2017-01-01)
Gluten-free diet (GFD) is the only treatment for celiac disease (CD). There is a general consensus that strict GFD adherence ...
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Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing

Moreno Amador, María de Lourdes; Cebolla, Ángel; Muñoz Suano, Alba; Carrillo Carrión, Carolina; Comino Montilla, Isabel María; Pizarro, Ángeles; Sousa Martín, Carolina (BMJ Publishing Group, 2017-01-01)
Objective Gluten-free diet (GFD) is the only management for coeliac disease (CD). Available methods to assess GFD compliance ...
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Characterization of celiac disease related oat proteins: bases for the development of high quality oat varieties suitable for celiac patients

Giménez, María J.; Real, Ana; García Molina, María Dolores; Sousa Martín, Carolina; Barro, Francisco (Nature Publishing Group, 2017-01-01)
Some studies have suggested that the immunogenicity of oats depends on the cultivar. RP-HPLC has been proposed as a useful ...
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Fecal Gluten Peptides Reveal Limitations of Serological Tests and Food Questionnaires for Monitoring Gluten-Free Diet in Celiac Disease Patients

Comino Montilla, Isabel María; Fernández Bañares, Fernando; Segura Montero, Verónica; Sousa Martín, Carolina; Esteve, María; Ortigosa, Luis (Nature Publishing Group, 2016-01-01)
Objectives: Treatment for celiac disease (CD) is a lifelong strict gluten-free diet (GFD). Patients should be followed-up ...
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Targeting of prolamins by RNAi in bread wheat: Effectiveness of seven silencing-fragment combinations for obtaining lines devoid of coeliac disease epitopes from highly immunogenic gliadins

Barro, Francisco; Iehisa, Julio C. M.; Giménez, María J.; García Molina, María D.; Ozuna Serafini, Carmen Victoria; Comino Montilla, Isabel María; Sousa Martín, Carolina; Gil Humanes, Javier (Wiley-Blackwell, 2016-01-01)
Gluten proteins are responsible for the viscoelastic properties of wheat flour but also for triggering pathologies in ...
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Identification and molecular characterization of oat peptides implicated on coeliac immune response

Comino Montilla, Isabel María; Bernardo, David; Bancel, Emmanuelle; Moreno Amador, María de Lourdes; Sánchez, Borja; Barro, Francisco; Šuligoj, Tanja; Ciclitira, Paul Jonathan; Cebolla, Ángel; Knight, Stella Catherine; Branlard, Gérard; Sousa Martín, Carolina (Co-Action Publishing, 2016-01-01)
Background : Oats provide important nutritional and pharmacological properties, although their safety in coeliac ...
Final Degree Project
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Estudio de la adherencia a la dieta sin gluten en pacientes celíacos pediátricos mediante la cuantificación de péptidos inmunogénicos del gluten en heces

Comino Montilla, Isabel María; Sousa Martín, Carolina; Lao Domínguez, Francisco Ángel (2016-01-01)
La enfermedad celíaca (EC) es un desorden clínico basado en una intolerancia al gluten presente en ciertos cereales como ...
Final Degree Project
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Actualización epidemiológica de las meningitis de origen bacteriano

Sousa Martín, Carolina; Benkhadda, Nada (2016-01-01)
La meningitis bacteriana es la forma más común de infecciones supurativas del Sistema Nervioso Central (SNC) y puede estar ...
Final Degree Project
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Detección de la fracción inmunotóxica del gluten en diferentes especies de cereales y su implicación en la enfermedad celíaca

Sousa Martín, Carolina; Comino Montilla, Isabel María; García Lloret, Patricia (2016-01-01)
La enfermedad celíaca (EC) es una patología que afecta al intestino delgado proximal y está asociada a una intolerancia ...
PhD Thesis
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Caracterización de comunidades microbianas en tumbas etruscas y romanas

Saiz Jiménez, Cesáreo; Laiz Trobajo, Leonila; Sousa Martín, Carolina; Díaz Herráiz, Marta (2015-06-30)
El biodeterioro es un problema frecuente en monumentos y en sitios arqueológicos, buen ejemplo de ello es el encontrado ...
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Role of oats in celiac disease

Comino Montilla, Isabel María; Moreno Amador, María de Lourdes; Sousa Martín, Carolina (Baishideng Publishing Group, 2015-01-01)
A gluten-free diet is currently the only effective means of treating individuals with celiac disease. Such a diet enables ...
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Diversification of the celiac disease α-gliadin complex in wheat: A 33-mer peptide with six overlapping epitopes, evolved following polyploidization

Ozuna Serafini, Carmen Victoria; Iehisa, Julio Cesar Masaru; Giménez Alvear, María J.; Álvarez, Juan B.; Sousa Martín, Carolina; Barro, Francisco (Wiley-Blackwell, 2015-01-01)
Summary The gluten proteins from wheat, barley and rye are responsible both for celiac disease (CD) and for non-celiac ...
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Reduced-gliadin wheat bread: An alternative to the gluten-free diet for consumers suffering gluten-related pathologies

Gil Humanes, Javier; Pistón, Fernando; Altamirano Fortoul, Rossana; Real, Ana; Comino Montilla, Isabel María; Sousa Martín, Carolina; Rossell, Cristina M.; Barro, Francisco (Public Library of Science, 2014-01-01)
Wheat flour cannot be tolerated by those who suffer allergies to gluten. Human pathologies associated with grain proteins ...
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Identification and in Vitro reactivity of celiac immunoactive peptides in an apparent gluten-free beer

Real, Ana; Comino Montilla, Isabel María; Moreno Amador, María de Lourdes; López Casado, Miguel Ángel; Lorite, Pedro; Cebolla, Ángel; Sousa Martín, Carolina (Public Library of Science, 2014-01-01)
Gluten content from barley, rye, wheat and in certain oat varieties, must be avoid in individuals with celiac disease. In ...
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Cereals for developing gluten-free products and analytical tools for gluten detection

Rossell, Cristina M.; Barro, Francisco; Sousa Martín, Carolina; Mena, Mª Carmen (Academic Press, 2014-01-01)
Recently, gluten free foods have attracted much research interest motivated by the increasing market. Despite the motivation ...
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Update on nutritional aspects of gluten-free diet in celiac patients

Moreno Amador, María de Lourdes; Comino Montilla, Isabel María; Sousa Martín, Carolina (Asian Medical Journals, 2014-01-01)
A strict gluten - free diet is the only currently available therapeutic treatment for patients with celiac disease, an ...
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Constitutive gut-homing capacity on circulating myeloid dendritic cells in coeliac disease

Comino Montilla, Isabel María; Šuligoj, Tanja; Al-Hassi, Hafid Omar; Lee, Gui Han; Sousa Martín, Carolina; Landy, Jonathan; Ciclitira, Paul Jonathan; Knight, Stella Catherine; Bernardo, David (Arán Ediciones, S.L., 2014-01-01)
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Alternative grains as potential raw material for gluten– free food development in the diet of celiac and gluten– sensitive patients

Moreno Amador, María de Lourdes; Comino Montilla, Isabel María; Sousa Martín, Carolina (Austin Publishing Group, 2014-01-01)
Celiac disease is an autoimmune disorder resulting from gluten intolerance and is based on a genetic predisposition. Gluten ...
PhD Thesis
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Evaluación de la eficacia de tratamientos de desinfesción de suelo en el control de hongos patógenos en el cultivo de la fresa, en las condiciones de cultivo de la provincia de Huelva

Santos García de Paredes, Berta de los; Sousa Martín, Carolina; Chamorro Rodríguez, Manuel (2014-01-01)
El cultivo de la fresa está muy extendido en los cinco continentes, siendo China y Estados Unidos los mayores productores ...
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Detection of specific IgA antibodies against a novel deamidated 8-mer gliadin peptide in blood plasma samples from celiac patients

Arranz, Eduardo; Cebolla Ramírez, Ángel; Sousa Martín, Carolina; Moreno Amador, María de Lourdes; Vallejo Díez, Sara; Bernardo, David; Muñoz Suano, Alba; Fernández Salazar, Luis; Calvo, Carmen; Garrote, José A. (2013-01-01)
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The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients

Comino Montilla, Isabel María; Moreno Amador, María de Lourdes; Real, Ana; Rodríguez Herrera, Alfonso; Barro, Francisco; Sousa Martín, Carolina (Multidisciplinary Digital Publishing Institute (MDPI), 2013-01-01)
A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease, ...
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Molecular and Immunological Characterization of Gluten Proteins Isolated from Oat Cultivars That Differ in Toxicity for Celiac Disease

Real, Ana; Comino Montilla, Isabel María; Lorenzo, Laura de; Merchán Ignacio, Francisco; Gil Humanes, Javier; Giménez, María J.; López Casado, Miguel Ángel; Torres, Mª Isabel; Cebolla, Ángel; Sousa Martín, Carolina; Barro, Francisco; Pistón, Fernando (Public Library of Science, 2012-01-01)
A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease ...
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Monitoring of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces

Comino Montilla, Isabel María; Real calderón, Ana; Vivas, Santiago; Síglez, Miguel Ángel; Caminero, Alberto; Nistal, Esther; Casqueiro, Javier; Rodríguez Herrera, Alfonso; Cebolla, Ángel; Sousa Martín, Carolina (Oxford University Press, 2012-01-01)
Background: Certain immunotoxic peptides from gluten are resistant to gastrointestinal digestion and can interact with ...
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Diversity in oat potential immunogenicity: basis for the selection of oat varieties with no toxicity in coeliac disease

Comino Montilla, Isabel María; Lorenzo Barrios, Laura de; Cornell, Hugh; López Casado, Miguel Ángel; Barro, Francisco; Sousa Martín, Carolina (BMJ Publishing Group, 2011-01-01)
Background and aims Coeliac disease (CD) is triggered by an abnormal reaction to gluten. Peptides resulting from partially ...
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A novel plant leucine-rich repeat receptor kinase regulates the response of medicago truncatula roots to salt stress

Lorenzo Barrios, Laura de; Merchán Ignacio, Francisco; Laporte, Philippe; Thompson, Richard D.; Clarke, Jonathan H.; Sousa Martín, Carolina; Crespi, Martín D. (American Society of Plant Biologists, 2009-01-01)
In plants, a diverse group of cell surface receptor-like protein kinases (RLKs) plays a fundamental role in sensing external ...
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Different and new Nod factors produced by Rhizobium tropici CIAT899 following Na+ stress

Estévez Amador, Jana; Soria Díaz, María Eugenia; Córdoba, F. F. de; Morón, Belén; Manyani, Hamid; Gil Serrano, Antonio Miguel; Thomas-Oates, Jane E.; Brussel, Anton Albertus Nicolaas van; Dardanelli, Marta Susana; Sousa Martín, Carolina; Megías, Manuel (Oxford University Press, 2009-01-01)
The root nodule bacterium Rhizobium tropici strain CIAT899 is highly stress resistant. It grows under acid conditions, in ...
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Toward the Assessment of Food Toxicity for Celiac Patients: Characterization of Monoclonal Antibodies to a Main Immunogenic Gluten Peptide

Morón Flores, Belén; Bethune, Michael T.; Comino Montilla, Isabel María; Manyani, Hamid; Ferragud, Marina; López, Manuel Carlos; Cebolla, Ángel; Khosla, Chaitan; Sousa Martín, Carolina (Public Library of Science, 2008-01-01)
Background and Aims: Celiac disease is a permanent intolerance to gluten prolamins from wheat, barley, rye and, in some ...
PhD Thesis
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Differential expression of the TFIIIA regulatory pathway in response to salt stress between Medicago truncatula genotypes

Lorenzo Barrios, Laura de; Merchán Ignacio, Francisco; Blanchet, Sandrine; Megías Guijo, Manuel; Frugier, Florian; Crespi, Martín D.; Sousa Martín, Carolina (American Society of Plant Biologists, 2007-01-01)
Soil salinity is one of the most significant abiotic stresses for crop plants, including legumes. These plants can establish ...
PhD Thesis
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Estudio de la transferencia de los plásmidos simbióticos entre especies de Rhizobium que nodulan Phaseolus Vulgaris

Sousa Martín, Carolina; Megías Guijo, Manuel; Gamane, Djamila (2005-02-15)
PhD Thesis
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Influencia del estrés abiótico en el establecimiento de la simbiosis Phaseolus vulgaris-Rhizobium spp

Sousa Martín, Carolina; Megías Guijo, Manuel; Morón Flores, Belén (2004-01-01)
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Translational and structural requirements of the early nodulin gene enod40, a short-open reading frame-containing RNA, for elicitation of a cell-specific growth response in the alfalfa root cortex

Sousa Martín, Carolina; Johansson, Christina; Charon, Céline; Manyani, Hamid; Sautter, Christof; Kondorosi, Ádam; Crespi, Martín D. (American Society for Microbiology, 2001-01-01)
A diversity of mRNAs containing only short open reading frames (sORF-RNAs; encoding less than 30 amino acids) have been ...
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Rational design of a bacterial transcriptional cascade for amplifying gene expression capacity

Cebolla, Ángel; Sousa Martín, Carolina; Lorenzo, Víctor de (Oxford University Press, 2001-01-01)
Cascade regulatory circuits have been described that control numerous cell processes, and may provide models for the design ...
PhD Thesis
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Análisis de los genes de nodulación implicados en la sulfatación de la molécula señal de Rhizobium tropici CIAT899

Megías Guijo, Manuel; Sousa Martín, Carolina; Manyani, Hamid (2000-04-18)
R.tropici CIAT899 es un simbionte de amplio rango de hospedador capaz de producir nódulos fijadores de nitrógeno en numerosas ...
PhD Thesis
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Estudio del polimorfismo en algunos genes simbióticos de rizobios aislados de suelos chinos y brasileños que nodulan en soja

Sousa Martín, Carolina; Megías Guijo, Manuel; Mateos Chávez, Clemente (1999-01-01)
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Metalloadsorption by Escherichia coli cells displaying yeast and mammalian metallothioneins anchored to the outer membrane protein LamB

Sousa Martín, Carolina; Kotrba, Pavel; Ruml, Tomáš; Cebolla, Ángel; Lorenzo, Víctor de (American Society for Microbiology, 1998-01-01)
Yeast (CUP1) and mammalian (HMT-1A) metallothioneins (MTs) have been efficiently expressed in Escherichia coli as fusions ...
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Effector specificity mutants of the transcriptional activator NahR of naphthalene degrading Pseudomonas define protein sites involved in binding of aromatic inducers

Cebolla, Ángel; Sousa Martín, Carolina; Lorenzo, Víctor de (American Society for Biochemistry and Molecular Biology Inc., 1997-01-01)
This work reports a genetic analysis of the interactions between NahR, the LysR-type regulator of the NAH operons for ...
PhD Thesis
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Introducción de forma estable de genes de la nodulación en el plásmido simbiótico de Rhizobium leguminosarum bv. trifolii RS1051

Megías Guijo, Manuel; Sousa Martín, Carolina (1992-12-18)
Una de las técnicas más poderosa usadas en la investigación de Rhizobium es la mutagénesis dirigida descrita por Ruvkun y ...